Citation: Kang Juan, Huang Danfeng, Wang Kehu, Su Yingpeng, Hu Yulai, Chang Qing. Synthesis of α-Trifluoromethyl-α-hydroxyl Weinreb Amides[J]. Chinese Journal of Organic Chemistry, ;2017, 37(1): 103-109. doi: 10.6023/cjoc201606034 shu

Synthesis of α-Trifluoromethyl-α-hydroxyl Weinreb Amides

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Huang Danfeng, huyl@nwnu.edu.cn Hu Yulai, huangdf@nwnu.edu.cn
Received Date: 22 June 2016
Revised Date: 12 September 2016

Fund Project: the National Natural Science Foundation of China 21462037the National Natural Science Foundation of China 21262031

Figures(2)

Selective trifluoromethylation of α-oxo-Weinreb amides was explored using trimethyl (trifluoromethyl) silane as fluorinating reagent. A series of α-trifluoromethyl-α-hydroxyl Weinreb amides were successfully synthesized and their reaction with organometallic reagents was investigated.
- trifluoromethylation,
- trimethyl (trifluoromethyl) silane,
- α-trifluoromethyl-α-hydroxyl Weinreb amides,
- Grignard reagents
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