Citation: Fu Shaobin, Meng Qingfengb, Xin Qinga, Xiao Shijia. Biocatalytic Synthesis of a Novel Corosolic Acid Derivative[J]. Chinese Journal of Organic Chemistry, ;2016, 36(11): 2743-2745. doi: 10.6023/cjoc201605011 shu

Biocatalytic Synthesis of a Novel Corosolic Acid Derivative

a.
School of Pharmacy, Zunyi Medical University, Zunyi 563000
b.
School of Public Health, Zunyi Medical University, Zunyi 563000

Corresponding author: Fu Shaobin, fushb@126.com
Received Date: 9 May 2016
Revised Date: 4 June 2016

Fund Project: the Program of Ministry of Education "Chunhui Plan" Z2014091National Natural Sciences Foundation of China 21462057the United Fund of Guizhou Province, Zunyi Medical University and Zunyi QKHLH-2014-7555

Corosolic acid, a pentacyclic triterpene acid, attracted more and more attention because of the significant anti-diabetes activity. Biocatalysis was applied to modify the structure of corosolic acid to increase the structural diversity of corosolic acid and lay the foundation for screening derivatives with novel structure or better activity. A novel corosolic acid derivative was synthesized by endophytic fungus Umbelopsis isabellina. The structure of the new compound was established by HR-ESIMS and NMR spectrum.
- corosolic acid,
- biocatalysis,
- hydroxylation,
- 2α, 3β, 7β-trihydroxy-urs-11-en-28, 13-lactone
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沈阳化工大学材料科学与工程学院沈阳 110142