Citation: Ao Yufei, Wang Qiqianga, Wang Dexiana. Biocatalytic Desymmetrization of Dinitriles in Organic Synthesis[J]. Chinese Journal of Organic Chemistry, ;2016, 36(10): 2333-2343. doi: 10.6023/cjoc201605009 shu

Biocatalytic Desymmetrization of Dinitriles in Organic Synthesis

Ao Yufei ^a,b,*,, ,
Wang Qiqianga ^a ,
Wang Dexiana ^a,b

a.
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190
b.
University of Chinese Academy of Sciences, Beijing 100049

Corresponding author: Ao Yufei, aoyufe@iccas.ac.cn
Received Date: 9 May 2016
Revised Date: 11 June 2016

Fund Project: Project supported by the National Natural Science Foundation of China No. 21502202

Figures(14)

In comparison with the chemical hydration and hydrolysis of nitriles, which usually involves harsh reaction condi-tions and low selectivity, biocatalytic desymmetrizations of prochiral or meso nitriles are highly efficient, highly enantioselective and environmentally benign. Therefore, biocatalysis and biotransformation has offered an attractive and unique protocol for the enantioselective synthesis of polyfunctionalized organic compounds that are not readily obtainable by other methods. This review summarizes the biocatalytic desymmetrization of prochiral nitriles including glutaronitriles, malonitriles and meso cyclic dinitriles during the past two decades.
- desymmetrization,
- biotransformations,
- dinitriles
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