Citation: Xiao Huifeng, Zhang Min, Liu Jie, Han Zhixiang, Yang Liuqing, Wu Xiangyang. A Novel Rhodamine B Fluorescent Probe for Hg²⁺: Synthesis and Evaluation[J]. Chinese Journal of Organic Chemistry, ;2016, 36(10): 2413-2418. doi: 10.6023/cjoc201604040 shu

A Novel Rhodamine B Fluorescent Probe for Hg²⁺: Synthesis and Evaluation

Xiao Huifeng ^a ,
Zhang Min ^a,*,, ,
Liu Jie ^a ,
Han Zhixiang ^b ,
Yang Liuqing ^a ,
Wu Xiangyang ^b,*,,

a.
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013
b.
School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013

Corresponding author: Zhang Min, zhangmin@ujs.edu.cn Wu Xiangyang, wuxy@ujs.edu.cn
Received Date: 19 April 2016
Revised Date: 19 May 2016

Fund Project: Natural Science Foundation of Jiangsu Province BK20140536

Figures(11)

A novel fluorescent probe R based on rhodamine B was synthesized by the condensation of rhodamine B hydrazide and phenylglyoxal monohydrate, followed by reduction with NaBH₄, and its structure was characterized by ¹H NMR, ¹³C NMR, ESI-MS, elemental analysis, and X-ray single analysis. It exhibited very strong fluorescence responses to Hg²⁺ with remarkably high selectivity for Hg²⁺ over other metal ions. When the concentration of Hg²⁺ was in the range of 5×10^-7~2×10^-6 mol/L, there was a good linearity between the fluorescence intensity and the concentration of Hg²⁺. The fluorescence imaging experiments of Hg²⁺ in MGC-803 living cells revealed its potential application in biological system.
- fluorescent probe,
- rhodamine B,
- mercury ion,
- cell imaging
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A Novel Rhodamine B Fluorescent Probe for Hg2+: Synthesis and Evaluation

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通讯作者: 陈斌, bchen63@163.com

A Novel Rhodamine B Fluorescent Probe for Hg²⁺: Synthesis and Evaluation