Citation: Li Yubo, Zhao Yunhui, Luo Mingjian, Tang Zilong, Cao Chaotun, Deng Keqin. Synthesis of Isoquinolines Derivatives from o-Alkynyl Aldehydes[J]. Chinese Journal of Organic Chemistry, ;2016, 36(10): 2504-2509. doi: 10.6023/cjoc201604031 shu

Synthesis of Isoquinolines Derivatives from o-Alkynyl Aldehydes

1.
Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education of China, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201

Corresponding author: Zhao Yunhui, zhao_yunhui@163.com Tang Zilong, zltang67@aliyun.com
Received Date: 14 April 2016
Revised Date: 20 May 2016

Fund Project: Project supported by the National Natural Science Foundation of China Nos.21372070, 21471052the Hunan Provincial Education Office Scientific Research Foundation Project No.14k035

Figures(4)

The isoquinoline and dihydroisoquinoline ring systems are found as the core nucleus in a wide variety of natural products and pharmaceutical agents with good biologically activity. Isoquinoline, benzoxazine-fused isoquinlines and pyrazo-lo[5,1-a]isoquinolines are prepared from o-alkynyl aldehydes and nitrogen-containing compounds via tandem reactions catalyzed by CuI or AgNO₃. The reactions have some advantages, such as mild reaction conditions, simple operation and easily available catalysts.
- isoquinoline,
- benzoxazine-fused isoquinlines,
- pyrazolo[5,1-a]isoquinolines,
- o-alkynyl aldehydes,
- tandem reaction
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沈阳化工大学材料科学与工程学院沈阳 110142