Citation: Liu Zizhao, Xu Fan. Synthesis of Chromans via Domino Reaction of Phenols with Prenyl Bromide Catalyzed by Zinc Chloride[J]. Chinese Journal of Organic Chemistry, ;2016, 36(10): 2499-2503. doi: 10.6023/cjoc201604021 shu

Synthesis of Chromans via Domino Reaction of Phenols with Prenyl Bromide Catalyzed by Zinc Chloride

Liu Zizhao ,
Xu Fan

1.
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123

Received Date: 11 April 2016
Revised Date: 11 May 2016

Fund Project: Project supported by the National Natural Science Foundation of China No.21272168

Figures(1)

Chroman skeleton exists in many natural and synthetic biologically active materials. A highly efficient method for the synthesis of chromans via reaction of phenols with prenyl bromide catalyzed by zinc chloride is described, which provides a practical process to afford this type of biologically important compounds in good yields using commercially available and inexpensive catalyst under mild conditions.
- chroman,
- zinc chloride,
- catalysis,
- prenyl bromide
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沈阳化工大学材料科学与工程学院沈阳 110142