Citation: Kong Lingbin, Yang Ruixia, Du Xuanxuan, Yan Shengjiao, Lin Jun. Simple Synthesis of Bicyclic Pyrrole Ketone Compounds[J]. Chinese Journal of Organic Chemistry, ;2016, 36(10): 2437-2441. doi: 10.6023/cjoc201604004 shu

Simple Synthesis of Bicyclic Pyrrole Ketone Compounds

1.
School of Chemical Science And Technology, Yunnan University, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Kunming 650091

Corresponding author: Yan Shengjiao, yansj@ynu.edu.cn;linjun@ynu.edu.cn Lin Jun, yansj@ynu.edu.cn;linjun@ynu.edu.cn
Received Date: 3 April 2016
Revised Date: 13 May 2016

Fund Project: and the Excellent Young Talents in Yunnan University No.XT412003Project supported by the National Natural Science Foundation of China Nos.U1202221，21362042，21662042the Talent Found in Yunnan Province No.2012HB001

Figures(2)

In this article, a one-pot protocol was established for the synthesis of bicyclic pyrrole ketone compounds. This method based on the building blocks of heterocyclic ketene aminals 1, which reacted with oxalaldehyde 2 in 1,4-dioxane at 50℃ and triethylamine as base. As a result, a series of bicyclic pyrrole ketone compounds 3a~3i have been synthesized. This reaction has some advantages such as simple synthetic route, readily available starting materials, high yields and simple work-up procedures.
- bicyclic pyrrole ketone,
- heterocyclic ketene aminals,
- oxalaldehyde
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