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Citation: Jiang Xiaoying, Mi Zhisheng, Guo Dongyan, Xie Yuanyuan, Jin Tingting, Wang Wenhui. An Efficient Method for the Synthesis of Substituted 5-Aminotetrazoles from Selenoureas[J]. Chinese Journal of Organic Chemistry, ;2016, 36(9): 2150-2156. doi: 10.6023/cjoc201603047 shu

An Efficient Method for the Synthesis of Substituted 5-Aminotetrazoles from Selenoureas

a.
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceutical, Zhejiang University of Technology, Hangzhou 310014
b.
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: Xie Yuanyuan, xyycz@zjut.edu.cn
Received Date: 30 March 2016
Revised Date: 22 April 2016

Fund Project: the Qianjiang Talent Project of Science Technology Department of Zhejiang Province 2013R10059the National Natural Science Foundation of China 21576239

Figures(3)

The method to synthesize 5-aminotetrazoles starting from 1, 3-disubtituted selenoureas using ion-supported hypervalent iodine(Ⅲ) reagent and sodium azide via electrocyclization has been discovered. The reaction has some advantages, such as using green and recyclable reagent[dibmim]⁺[PF₆]^-, environmental benign, short reaction time, good selectivity and high yield. The reaction is in line with the requirements of green chemistry.
- selenourea,
- ionic liquids,
- hypervalent iodine(Ⅲ),
- electrocyclization,
- aminotetrazoles
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