Citation: Zhang Wei, Xu Niwei, Yao Zijian, Li Kuan, Zhu Yu, Chen Liangyan, Ye Wenling, Deng Wei. Recent Progress of Nucleic Acid Vector Based on Dendritic Polymers[J]. Chinese Journal of Organic Chemistry, ;2016, 36(9): 2039-2052. doi: 10.6023/cjoc201603046 shu

Recent Progress of Nucleic Acid Vector Based on Dendritic Polymers

Zhang Wei ^a,b ,
Xu Niwei ^c ,
Yao Zijian ^b,*,, ,
Li Kuan ^b ,
Zhu Yu ^b ,
Chen Liangyan ^b ,
Ye Wenling ^b ,
Deng Wei ^a,b,*,,

a.
School of Materials Science and Engineering, Shanghai University, Shanghai 200444
b.
School of Chemical and Engineering, Shanghai Institute of Technology, Shanghai 201418
c.
Traditional Chinese Medical College, Zhuzhou 412012

Corresponding author: Yao Zijian, wdeng@shu.edu.cn Deng Wei, zjyao@sit.edu.cn
Received Date: 28 March 2016
Revised Date: 5 May 2016

Fund Project: Project supported by the Shuguang Scholar Project, the National Natural Science Foundation of China 21174081the Natural Science Foundation of Shanghai City 16ZR1435700Project supported by the Shuguang Scholar Project, the National Natural Science Foundation of China 21601125

Figures(19)

Secure and efficient gene carrier has important application in gene therapy. Compared with viral gene vectors, non-viral gene vec-tor has attracted much attention because of their low immunogenicity, easy mass production and low costs. However, they showed limited activity in transfection efficiency and selectivity. This paper reviewed recent research progress in dendritic poly-mers gene carriers, including (ⅰ) dendritic and derived materials, (ⅱ) supramolecular parent materials, such as the carrier combined with cyclodextrins, and cucurbituril in multivariate and block type pattern, (ⅲ) dendritic polymers gene vector combined with inorganic material, such as gold nanoparticles, iron oxide nanoparticles and graphene, and (ⅳ) functional response type dendritic polymers gene vector, such as the pH response type vector, two disulfide response type vector, redox hyperbranched gene carrier and fluorinated dendrimers as gene vectors.
- hyperbranched polymer,
- gene delivery,
- dendrimer,
- gene therapy
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