Citation: Cao Tuanwu, He Kang, Geng Chang'an, Zhang Xuemei, Zhou Jun, Chen Jijun. Two New Linear Monoterpenoids from Swertia mussotii[J]. Chinese Journal of Organic Chemistry, ;2016, 36(9): 2216-2219. doi: 10.6023/cjoc201603038 shu

Two New Linear Monoterpenoids from Swertia mussotii

Cao Tuanwu ^a,b ,
He Kang ^a ,
Geng Chang'an ^a ,
Zhang Xuemei ^a ,
Zhou Jun ^a ,
Chen Jijun ^a,*,,

a.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201
b.
Laboratory of Natural Medicine Research and Development in Wuling Mountain, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100

Corresponding author: Chen Jijun, chenjj@mail.kib.ac.cn
Received Date: 23 March 2016
Revised Date: 29 April 2016

Fund Project: the National Science Foundation of China for Distinguished Young Scholar 81025023

Figures(3)

Investigation on Swertia mussotii resulted in four compounds by means of various chromatographic techniques (silica gel, Sephadex LH-20, RP-LC and Pre-HPLC). Their structures were determined as (S, 2E, 6E)-4, 8-dihydroxy-2, 6-dime-thylocta-2, 6-dienoic acid (1), (S, 2E, 6E)-8-(formyloxy)-4-hydroxy-2, 6-dimethylocta-2, 6-dienoic acid (2), swerimilegenins B and C (3 and 4) on the basis of extensive spectroscopic analyses including MS, IR, UV, 1D-and 2D-NMR. Among them, compounds 1 and 2 are two new linear monoterpenoids named as swerimusic acids C (1) and D (2), compounds 3 and 4 are two unusual known secoiridoid aglycones of C₉-skeleton obtained for the first time from this plant. Compounds 1~4 were evaluated for their anti-Hepatitis B Virus (HBV) activities on HepG2.2.15 cells line in vitro, but these compounds showed no anti-HBV activity at the maximal tesing concentration. Herin, we only report the isolation and structure elucidation of these compounds.
- Gentianaceae,
- Swertia mussotii,
- linear monoterpenoid,
- swermusic acids C and D
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