Citation: Ma Yangmin, Fan Chao. Progress in the Synthesis of Spirotryprostatin Alkaloids[J]. Chinese Journal of Organic Chemistry, ;2016, 36(10): 2380-2396. doi: 10.6023/cjoc201603031 shu

Progress in the Synthesis of Spirotryprostatin Alkaloids

Ma Yangmin ^*,, ,
Fan Chao

1.
Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021

Corresponding author: Ma Yangmin, mym63@sina.com
Received Date: 18 March 2016
Revised Date: 17 May 2016

Fund Project: Project supported by the Scientific Research Project Item for Key Laboratory of Shaanxi Province Education Department No.2010JS056

Figures(20)

Spirotryprostatin is one of the alkaloids which contains the spiro-indolyl diketopiperazine structure. It is structurally characterized by indole moiety connected to diketopiperazine moiety via the spiro quaternary carbon chiral center. The combination of the structure of spiro-indoyl and diketopiperazine has demonstrated the special physiological and pharmacological activities, especially the excellent inhibitory activity to cell cycle. In recent years, The synthesis of spirotryprostatin has attracted much attention, according to the formation of the spirocyclic chiral center. The total synthetic efforts towards spirotryprostatin alkaloids are presented.
- spirotryprostatin,
- spiro-indolyl diketopiperazine,
- alkaloid,
- biological activity,
- total synthesis
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沈阳化工大学材料科学与工程学院沈阳 110142