Citation: Zhang Song, Lu Junzhu, Ye Jinxing, Duan Wei-liang. Asymmetric C-H Arylation for the Synthesis of Planar Chiral Ferrocenes: Controlling Enantioselectivity Using Chiral Phosphoric Acids[J]. Chinese Journal of Organic Chemistry, ;2016, 36(4): 752-759. doi: 10.6023/cjoc201602032 shu

Asymmetric C-H Arylation for the Synthesis of Planar Chiral Ferrocenes: Controlling Enantioselectivity Using Chiral Phosphoric Acids

a.
a. School of Pharmacy, East China. University of Science and Technology, Shanghai 200237;
b.
b. State Key Laboratory of Organometallic. Chemistry, Shanghai Institute of Organic. Chemistry, Chinese Academy of Sciences, Shanghai 200032

Corresponding author: Ye Jinxing, Duan Wei-liang,
Received Date: 28 February 2016
Available Online: 30 March 2016
Fund Project: 国家自然科学基金(Nos.20902099,21172238,21472218)资助项目. (Nos.20902099,21172238,21472218)

Transition-metal-catalyzed direct activation reactions of unreactive C-H bond has been extensively developed in recent years. Although numerous synthetic methods have been reported to build diverse complex compounds, enantioselective C-H activation has not been paid much attention probably because of the absence of suitable ligands to control the stereoselectivity in the C-H activation reaction. Herein, a Pd(0)-catalyzed enantioselective synthesis of planar chiral ferrocenes was described, and chiral phosphoric acids were used as the only chiral source to control the stereoselectivity in the C-H activation reactions.
- palladium catalysis,
- C-H activation,
- asymmetric catalysis,
- chiral phosphoric acids,
- ferrocenes
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