Citation: Song Ran, Yuan Binhua, Sun Xingwen, Lin Guoqiang. A Convenient Access to 1-Aminoindans via Intramolecular Heck Reaction[J]. Chinese Journal of Organic Chemistry, ;2016, 36(6): 1308-1315. doi: 10.6023/cjoc201602024 shu

A Convenient Access to 1-Aminoindans via Intramolecular Heck Reaction

Song Ran ^a ,
Yuan Binhua ^a ,
Sun Xingwen ^a,*,, ,
Lin Guoqiang ^b

a.
Department of Chemistry, Fudan University, Shanghai 200433
b.
CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai 200032

Corresponding author: Sun Xingwen, sunxingwen@fudan.edu.cn
Received Date: 24 February 2016
Revised Date: 5 April 2016

Fund Project: Project supported by the National Natural Science Foundation of China No. 21472019

Figures(5)

The aminoindan skeleton, which widely exists in natural products and drug molecules. A convenient approach, aza-Barbier reaction and intramolecular Heck reaction, was successfully developed for the construction of this skeleton. Enantioenriched 3-methylene-1-amino-2-indanol was also synthesized via this method.
- aminoindan,
- aza-Barbier reaction,
- intramolecular Heck reaction
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