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Citation: Zhao Qun, Yao Changsheng, Wang Xiangshan. Synthesis of Quinopyrroloquinoline Derivatives under Catalyst-Free Conditions[J]. Chinese Journal of Organic Chemistry, ;2016, 36(8): 1932-1936. doi: 10.6023/cjoc201602001 shu

Synthesis of Quinopyrroloquinoline Derivatives under Catalyst-Free Conditions

a.
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023
b.
Jiangsu Key Laboratory of Green Synthesis for Functional Materials, School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Corresponding author: Wang Xiangshan, xswang@jsnu.edu.cn
Received Date: 1 February 2016
Revised Date: 25 March 2016

Fund Project: the Major Natural Science Foundation of Jiangsu Province No. 14KJA150004

Figures(4)

In this paper, a series of 13-aryl-6,13-dihydro-3H-quino[4,3-b]pyrrolo[3,2-f]quinolin-12(11H)-one derivatives was synthesized in EtOH under catalyst-free conditions using aromatic aldehydes, 5-aminoindole and 4-hydroxyquinolin-2(1H)-one as reactants. The structure of 4b was confirmed by X-ray diffraction analysis. This procedure has the advantages of simplicity and easy operation. An efficient method for the synthesis of fused pentacyclic heterocycles containing biquinolines moieties is provided.
- quinopyrroloquinoline,
- 5-aminoindole,
- catalyst-free,
- synthesis
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