Citation: Ren Shaobo, Zhang Haifeng, Zhang Jian, Zhang Wei, Liu Yunkui. Dichlorinating Reaction of N-Chlorosuccinimide with Isonitriles for the Synthesis of N-Phenyldichloroimides[J]. Chinese Journal of Organic Chemistry, ;2016, 36(8): 1954-1957. doi: 10.6023/cjoc201601033 shu

Dichlorinating Reaction of N-Chlorosuccinimide with Isonitriles for the Synthesis of N-Phenyldichloroimides

1.
State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: Liu Yunkui, ykuiliu@zjut.edu.cn
Received Date: 25 January 2016
Revised Date: 30 March 2016

Fund Project: the National Natural Science Foundation of China Nos. 21172197 and 21372201

Figures(1)

With N-chlorosuccinimide as the chlorinating source, the dichlorination of isonitriles has been achieved to afford N-phenyldichloroimide compounds under mild and convenient conditions. The optimized reaction conditions were established through systematic investigations of the effect of solvents, temperature, time, chlorinating sources and their dosages in the reaction. The reaction exhibits good compatibility of various substrates, and a variety of isonitriles with different substituted patterns can undergo the dichlorination smoothly and furnish products with high yields of up to 93%.
- isonitrile,
- N-chlorosuccinimide,
- N-phenyldichloroimide,
- dichlorination
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