Citation: Lü Chengwei, Liu Yanhang, Zhou Xiaoxia. Efficient and Green Synthesis of 5-[(Indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives in the Melt[J]. Chinese Journal of Organic Chemistry, ;2016, 36(6): 1407-1411. doi: 10.6023/cjoc201601010 shu

Efficient and Green Synthesis of 5-[(Indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives in the Melt

1.
Shcool of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029

Corresponding author: Lü Chengwei, chengweilv@126.com
Received Date: 10 January 2016
Revised Date: 1 February 2016

Fund Project: Project supported by the National Natural Science Foundation of China No. 21403100and the Doctoral Scientific Research Foundation of Liaoning Province No. 20141100

An efficient melting method for the synthesis of β-indole derivatives via Yonemitsu reaction was developed successfully using aldehyde, indole and Meldrum's acid as the starting materials and 50 μL water as green promoter without other solvent. A series of 5-[(indole-3-yl)-arylmethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized in 55%~94% yields. The remarkable advantages of this reaction were mild reaction condition, easy operation, tolerant the substrates with diverse functional groups and environment-friendly.
- melting method,
- multicomponent reaction,
- water,
- β-indole derivatives,
- green chemistry
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