Citation: Li Xinmin, Liu Chun, Liu Chao, Jin Zilin. Palladium-Catalyzed Ligand-Free Suzuki Reaction of Potassium Aryltrifluoroborates in Aqueous Ethanol[J]. Chinese Journal of Organic Chemistry, ;2016, 36(6): 1341-1350. doi: 10.6023/cjoc201601001 shu

Palladium-Catalyzed Ligand-Free Suzuki Reaction of Potassium Aryltrifluoroborates in Aqueous Ethanol

1.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012

Corresponding author: Liu Chun, cliu@dlut.edu.cn
Received Date: 2 January 2016
Revised Date: 20 January 2016

Fund Project: Project supported by the National Natural Science Foundation of China Nos. 21276043, 21421005and the Research Foundation of Dalian University of Technology for Retired Professors No. DUTTX2015102

Figures(1)

A simple and ligand-free protocol has been developed for the Pd(OAc)₂-catalyzed Suzuki reaction of potassium aryltrifluoroborates in aqueous ethanol under air. In the presence of Pd(OAc)₂ and 1 equiv. of K₂CO₃, aryl or heteroaryl halides coupled with various potassium aryltrifluoroborates smoothly to afford the products in high yields with the highest turnover frequency (TOF) up to 4656 h^-1, and a series of triphenylamine derivatives were prepared efficiently in this system. In addition, the active catalyst was proved to be the in situ-generated palladium nanoparticles according to TEM analysis and mercury-poisoning test.
- palladium,
- ligand-free,
- Suzuki reaction,
- potassium aryltrifluoroborates,
- aqueous ethanol
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沈阳化工大学材料科学与工程学院沈阳 110142