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Citation: Zheng Dongqing, Cao Wei, Ma Haiyan, Ding Kai. Efficient Synthesis of Chloromethyl Methyl Ether and One-Pot Hydroxyl Protection[J]. Chinese Journal of Organic Chemistry, ;2016, 36(5): 1122-1126. doi: 10.6023/cjoc201512013 shu

Efficient Synthesis of Chloromethyl Methyl Ether and One-Pot Hydroxyl Protection

Zheng Dongqing ^a ,
Cao Wei ^a ,
Ma Haiyan ^a,*,, ,
Ding Kai ^b,*,,

a.
Laboratory of Organometallic, East China University of Science and Technology, Shanghai 200237
b.
CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Corresponding author: Ma Haiyan, haiyanma@ecust.edu.cn Ding Kai, dingkai@mail.sioc.ac.cn
Received Date: 9 December 2015
Revised Date: 5 January 2016

Fund Project: Project supported by the National Natural Science Foundation for Young Scientists of China No.20902098

Chloromethyl methyl ether (MOMCl) is an important protecting agent in organic synthesis. An efficient synthesis of chloromethyl methyl ether is reported and a one-pot hydroxyl protection procedure is developed. The method features mild condition, short reaction time, high yield and simple operation.
- chloromethyl methyl ether,
- hydroxyl protecting agent,
- one-pot
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