Citation: Zhang Jin, Cheng Pei, Ma Yangmin, Liu Jia, Miao Zhi, Fan Chao. Ultrasonic Synthesis and Anti-phytopathogenic Fungi Activity Evaluation of 2-Sulfanylidene-2,3-dihydroquinazoline-4(1H)-one[J]. Chinese Journal of Organic Chemistry, ;2016, 36(6): 1368-1374. doi: 10.6023/cjoc201512008 shu

Ultrasonic Synthesis and Anti-phytopathogenic Fungi Activity Evaluation of 2-Sulfanylidene-2,3-dihydroquinazoline-4(1H)-one

1.
Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021

Corresponding author: Ma Yangmin, mym63@sina.com
Received Date: 5 December 2015
Revised Date: 28 January 2016

Fund Project: and the Foundation for Young Scholars of Shaanxi University of Science & Technology No. BJ12-26Project supported by the Natural Science Basic Research Plan in Shaanxi Province No. 2014JQ2064

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In order to develop new potent anti-phytopathogenic fungi drugs, a series of 2-sulfanylidene-2,3-dihydroquinazo- line-4(1H)-ones were synthesized under ultrasonic irradiation. Structures of the compounds were characterized by IR, ¹H NMR, ¹³C NMR and MS. All compounds were investigated for anti-phytopathogenic fungi activity via the method of minimum inhibitory concentrations. The majority of compounds exhibited a good inhibitory activity to Alternaria brassicae and Colletotrichum gloeosporioides. The minimum inhibitory concentrations of compounds 3a, 3b, 3g and 3h were 16 μg/mL, which showed significant inhibitory activity to Alternaria brassicae compared with that of the positive control drug ketoconazole.
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142