Citation: Li Linbin, Shen Yang, Zhang Yandong. Synthetic Progress of Jiadifenolide[J]. Chinese Journal of Organic Chemistry, ;2016, 36(3): 439-446. doi: 10.6023/cjoc201511054 shu

Synthetic Progress of Jiadifenolide

1.
Department of Chemistry and Fujian Provincial Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005

Corresponding author: Zhang Yandong, ydzhang@xmu.edu.cn
Received Date: 30 November 2015
Revised Date: 29 December 2015

Fund Project: the National Natural Science Foundations of China 21572187the National Natural Science Foundations of China 21142007the National Natural Science Foundations of China U1405228the Fundamental Research Funds for the Central Universities 20720160025the National Natural Science Foundations of China 21272194

Figures(10)

Jiadifenolide, a new seco-prezizaane-type sesquiterpenoid, was isolated from Chinese unique medicine Illicium jiadifengpi. It contains a highly oxygenated cagelike architecture with seven contiguous stereocenters. It displays potent neurotrophic activity at very low concentration and is regarded as a promising lead compound for developing drugs for neurodegenerative diseases. This review summarizes the synthetic efforts towards jiadifenolide in the last five years.
- jiadifenolide,
- seco-prezizaane-type sesquiterpenoid,
- neurotrophic agent,
- neurodegenerative diseases,
- total synthesis
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沈阳化工大学材料科学与工程学院沈阳 110142