Citation: Xu Yangrong, Wang Wenzhi, Yang Jingjing, Li Xinli, Meng Qingguo. Advances in the Synthesis and Biological Activities of Ocotillol-Type Saponins[J]. Chinese Journal of Organic Chemistry, ;2016, 36(4): 724-735. doi: 10.6023/cjoc201510022 shu

Advances in the Synthesis and Biological Activities of Ocotillol-Type Saponins

1.
School of Pharmacy, Yantai University, Yantai 264005

Corresponding author: Meng Qingguo,
Received Date: 19 October 2015
Available Online: 10 November 2015
Fund Project: 国家自然科学基金(No.81473104) (No.81473104)山东省自然科学基金(No.ZR2012HM036)资助项目. (No.ZR2012HM036)

Ocotillol-type saponins are a kind of tetracyclic triterpenoid ginsenoside with a tetrahydrofuran ring in the side chain. Ocotillol-type saponins mainly exist in panax plants and possess anti-inflammatory, antibacterial, morphine-antagonis- tic, neuroprotective, cardioprotective effects, etc. There are less ocotillol-type saponins in natural plants. Recently, many studies on the semi-synthesis, absolute configuration confirmation using X-ray diffraction, effect of anti-myocardial ischemic and metabolism of 20(S)-ocotillol-type saponins have been reported. It was found that 24R-epimer and 24S-epimer had stereoselectivity in anti-ischemic effect and pharmacokinetics. In this paper, the advances of the separation, synthesis, absolute configuration confirmation, pharmacological activity, metabolism of ocotillol-type saponins are reviewed.
- ocotillol-type ginsenoside,
- synthesis,
- absolute configuration confirmation,
- biological activities,
- metabolism
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