Citation: Dai Hong, Chen Jia, Cao Xiongfei, Miao Wenke, Shi Yujun, Fang Jianxin, Ye Linyu, Zhong Sulin. Synthesis and Bioactivity of Novel Pyridine Phenyl Ethers Bearing N-heterocycles[J]. Chinese Journal of Organic Chemistry, ;2016, 36(2): 377-383. doi: 10.6023/cjoc201510020 shu

Synthesis and Bioactivity of Novel Pyridine Phenyl Ethers Bearing N-heterocycles

Dai Hong ^a,c ,
Chen Jia ^a ,
Cao Xiongfei ^b ,
Miao Wenke ^c ,
Shi Yujun ^a,b,, ,
Fang Jianxin ^c ,
Ye Linyu ^a ,
Zhong Sulin ^b,,

1.
a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
2.
b United Nations Nantong Pesticide Forulation Development Centre, Nantong 226006;
3.
c State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: Shi Yujun, Zhong Sulin,
Received Date: 19 October 2015
Available Online: 5 November 2015
Fund Project: 国家自然科学基金(Nos. 21202089, 21372135) (Nos. 21202089, 21372135)南通市科技计划(Nos. AS2013004, MS22015020, AS2014011)资助项目 (Nos. AS2013004, MS22015020, AS2014011)

In order to find novel pyridine phenyl ether lead compounds, a series of novel pyridine phenyl ether derivatives containing N-heterocycles were prepared by the strategy of active substructure combination. Their structures were determined by ¹H NMR, ¹³C NMR, IR and elemental analysis. Preliminary bioassay data displayed that some of the designed compounds exhibited good insecticidal activity. Additionally, some target compounds showed significant anti-tumor activities.
- N-heterocycle,
- pyridine phenyl ether,
- synthesis,
- bioactivity
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