Citation: Hu Chongbo, Liu Jianhua, Du Xiaohua. Synthesis and Insecticidal Activities of N-(tert-Butyl)-N'-fluorobenzoyl-substitutedpyridylcarbonyl Hydrazide Derivatives[J]. Chinese Journal of Organic Chemistry, ;2016, 36(5): 1051-1059. doi: 10.6023/cjoc201510019 shu

Synthesis and Insecticidal Activities of N-(tert-Butyl)-N'-fluorobenzoyl-substitutedpyridylcarbonyl Hydrazide Derivatives

1.
Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology, Zhejiang Green Pesticide Collaborative Innovation Center, Catalytic Hydrogenation Research Center, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: Du Xiaohua, duxiaohua@zjut.edu.cn
Received Date: 17 October 2015
Revised Date: 15 December 2015

Figures(2)

In order to find novel diacylhydrazine derivatives which possessed high activities against pests, 20 novel N-(tert-butyl)-N'-fluorobenzoyl-substitutedpyridylcarbonyl hydrazide derivatives were synthesized by introducing fluoro-contained phenyl and pyridine into the basic structure of diacylhydrazines. Their structures were confirmed by ¹H NMR, ¹³C NMR, IR and HRMS. The bioassay results indicated that most of the compounds exhibited more than 80% mortality against Mythimna separateat the concentration of 500 mg/L. Among these compounds, N-(tert-butyl)-N'-(2,6-difluorobenzoyl)-N-2-chloronico-tinohydrazine (6bb)andN-(tert-butyl)-N'-(2,6-difluorobenzoyl)-N-2,5-dichloronicotinohydrazine (6gb)exhibited 100% and 80% mortality against Mythimna separateat 10 mg/L, respectively. The LC₅₀ of compound 6bb against Mythimna separatawas 8.77 mg/L, and it showed about 0.51 times of toxicity against Mythimna separatethan tebufenozide and had 1.5 times of toxicity against Plutella xylostella than tebufenozide.
- diacylhydrazine,
- pyridylcarbonyl hydraziden,
- synthesis,
- insecticidal activity
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沈阳化工大学材料科学与工程学院沈阳 110142