Citation: Wang Haifei, Zhou Zhipeng, Hu Shunqin, Wen Pushan, Tao Bin, Deng Qifu. Piperidinium Acetate-Catalyzed the Synthisis of 2, 3-Disubstituted Chroman-4-one and 2, 2-Disubstituted Benzofuran-3-one Derivatives[J]. Chinese Journal of Organic Chemistry, ;2016, 36(3): 596-603. doi: 10.6023/cjoc201510014 shu

Piperidinium Acetate-Catalyzed the Synthisis of 2, 3-Disubstituted Chroman-4-one and 2, 2-Disubstituted Benzofuran-3-one Derivatives

1.
School of Packaging and Materials Engineering, Hunan University of Technology, Zhuzhou 412007

Corresponding author: Wang Haifei, whf2107@hotmail.com
Received Date: 13 October 2015
Revised Date: 3 November 2015

Fund Project: the Hunan Provincial Natural Science Foundation of China 2015JJ3063the Natural Science Foundation of China 21202042the Natural Science Foundation of Hunan University of Technology 2014HZX01the Hunan Provincial Natural Science Foundation of China 13JJ4090

Figures(3)

A piperidinium acetate-catalyzed method was developed for the Knoevenagel and O-Micheal cascade reaction of o-hydroxyphenyl-β-diketoes with different series of aldehydes. In the presence of piperidinium acetate, sixteen 2, 3-disub-stituted chroman-4-ones and nine 2, 2-disubstituted benzofuran-3-ones were obtained in moderate to good yields, and the cascade reaction displayed better substrate adaptability. Moreover, the reaction has the following features: a convenient and simple path, mild reaction conditions and a cheap catalyst.
- piperidinium acetate,
- cascade reaction,
- chroman-4-one,
- benzofuran-3-one
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沈阳化工大学材料科学与工程学院沈阳 110142