Citation: Xu Zhaohui, Zhou Peng, Liu Deyong. Efficient One-Pot Synthesis of 3,3-Dimethyl-diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5-dione-9-thione Derivatives[J]. Chinese Journal of Organic Chemistry, ;2016, 36(5): 1099-1103. doi: 10.6023/cjoc201510009 shu

Efficient One-Pot Synthesis of 3,3-Dimethyl-diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]undecane-1,5-dione-9-thione Derivatives

Xu Zhaohui ^a,*,, ,
Zhou Peng ^b ,
Liu Deyong ^a

a.
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022
b.
School of New Energy and Enviroment Engineering, Nanchang Institute of Technology, Nanchang 330029

Corresponding author: Xu Zhaohui, gotoxzh@163.com
Received Date: 10 October 2015
Revised Date: 3 December 2015

Fund Project: and the Graduate Innovation Foundation of Jiangxi Province No.YC2015-B023Project supported by the National Science and Technology Project No.2001BA323C

Figures(3)

Six kinds of 3,3-dimethyl-diphenyl-2,4-dioxa-8,10-diazaspiro[5.5]-undecane-1,5-dione-9-thione derivatives were sythesized by the three component one-pot reaction of aromatic aldehydes with thiourea and 2,2-dimethyl-1,3-dio-xane-4,6-dione in the presence of molecular iodine under solvent-free conditions. The results indicated that the yields ranged from 73% to 91% at 80 ℃ for 3.0~6.0 h using 10 mol% iodine (relative to the substrate of 2,2-dimethyl-1,3-dioxane-4,6-dione). Furthermore, the present procedure with high yields was milder conditions and simpler post-treatment process.
- molecular iodine,
- solvent-free,
- three component condensation reaction,
- spiro hetrobicyclic compounds
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