Citation: Zhang Bianxiang, Yang Lihua, Shi Ruixue, Kang Yongqiang. Synthesis of Heterocyclic Aromatic Sulfides under Microwave Irradiation[J]. Chinese Journal of Organic Chemistry, ;2016, 36(2): 352-357. doi: 10.6023/cjoc201509026 shu

Synthesis of Heterocyclic Aromatic Sulfides under Microwave Irradiation

1.
School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006

Corresponding author: Zhang Bianxiang,
Received Date: 21 September 2015
Available Online: 14 October 2015
Fund Project: 山西省科技创新项目(No. 2014101011) (No. 2014101011)山西大学本科生科研训练(No. 2014013)资助项目 (No. 2014013)

The reaction of the thiolazole compounds with aryl iodide resulted in a series of aryl thioether compounds under microwave irradiation. It showed that the yield of target product was 88% when the reaction was carried out under microwave (30 W) heating for 15 min in N,N-dimethylformamide (DMF). The target products using microwave response and oil bath heating were tracked separately by high performance liquid chromatography (HPLC) analysis under the same conditions. The results showed that the method of microwave irradiation for the preparation of aryl sulfide was simple, efficient, time-saving and less by-products. It is expected to become an efficient, gentle and environmentally friendly synthetic method of heterocyclic aryl sulfides.
- 2-mercaptobenzo heterocyclic,
- aryl iodide,
- aryl thioether,
- microwave irradiation,
- high performance liquid chromatography (HPLC)
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