Citation: Zhou Peng, Qiu Huihua, Shi Jicheng. Palladium Catalyzed Cascade Cyclization of ortho-Alkenyl Bromobenzenes and Internal Alkynes for Multisubstituted Indenes[J]. Chinese Journal of Organic Chemistry, ;2016, 36(2): 425-431. doi: 10.6023/cjoc201508025 shu

Palladium Catalyzed Cascade Cyclization of ortho-Alkenyl Bromobenzenes and Internal Alkynes for Multisubstituted Indenes

1.
School of Chemical Engineering, Guangdong University of Petrochemical Technology, Maoming 525000

Corresponding author: Zhou Peng, zzd83@aliyun.com
Received Date: 25 August 2015
Revised Date: 12 October 2015

Fund Project: the Natural Science Foundation of Guangdong Province S2013040014944the National Natural Science Foundation of China 21272037

Figures(2)

This paper developed a new method for the construction of polysubstituted indenes. And a number of multisubstituted indenes have been synthesized from functional o-alkenyl bromobenzenes and alkynes in good yields through palladium-catalyzed annulations in N, N-dimethylformamide (DMF) taking Na₂CO₃as base. The methodology tolerates a variety of functional groups with simple reaction conditions and the catalyst can be reused.
- Pd-catalyzed,
- alkyne,
- o-alkenyl bromobenzene,
- indene,
- cascade reaction
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沈阳化工大学材料科学与工程学院沈阳 110142