Citation: Wang Kehu, Yin Xuejiao, Tao Rui, Huang Danfeng, Su Yingpeng, Hu Yulai, Fu Ying, Du Zhengyin, Wang Jinxian. Study on the Grinding-Induced Solvent-Free Preparation of 3-Styryl-1, 5-diketones[J]. Chinese Journal of Organic Chemistry, ;2015, 36(1): 113-120. doi: 10.6023/cjoc201507017 shu

Study on the Grinding-Induced Solvent-Free Preparation of 3-Styryl-1, 5-diketones

1.
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Corresponding author: Wang Kehu, wangkh@nwnu.edu.cn Hu Yulai,
Received Date: 17 July 2015
Revised Date: 13 October 2015

Fund Project: 21262031 the National Natural Science Foundation of China

Figures(2)

A convenient procedure for the synthesis of 3-styryl-1, 5-dicarbonyl compounds has been developed under solvent-free grinding conditions. α, β-Unsaturated aldehydes react with aromatic ketones to give the corresponding dienone products, then followed by a Michael addition producing 3-styryl-1, 5-dicarbonyl compounds in the presence of NaOH at room temperature. The advantages of this procedure are solvent-free, catalyst-free, mild reaction conditions, simple procedure, and short reaction time.
- solvent-free,
- grinding,
- aldol-Michael addition,
- 1, 5-diketones
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