Citation: Feng Jun, Ablajan Keyume, Ma Xiabing, Li Wenbo, Obul Mamateli. Multi-Component One-Pot Reactions for the Synthesis ofSpirooxindole-pyrano[2, 3-c]pyrazole Derivatives[J]. Chinese Journal of Organic Chemistry, ;2015, 36(1): 222-228. doi: 10.6023/cjoc201507011 shu

Multi-Component One-Pot Reactions for the Synthesis ofSpirooxindole-pyrano[2, 3-c]pyrazole Derivatives

1.
Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046

Corresponding author: Ablajan Keyume, ablajan209@hotmail.com
Received Date: 15 July 2015
Revised Date: 29 August 2015

Fund Project: National Natural Science Foundation of China 21462041Graduate Student Research Innovation Project of Xinjiang Educational Department XJGRI2014019

Figures(1)

A highly efficient strategy for the one-pot synthesis of multi-substituted spirooxindol-pyrano[2, 3-c]pyrazole derivatives was developed. The product formed in good yield from the reaction of acetylenedicarboxylate, hydrazine, isatin, and (E)-1-methylthio-1-methylamino-2-nitroethylene in the presence of Et₃N catalyst. This simple and convenient method could also be used to prepare similar types of product.
- spirooxindole,
- multi-component reaction,
- one-pot synthesis,
- pyrano[2, 3-c]pyrazole
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