Citation: Zhou Jiashen, Zhang Lin, Zhang Liang. Advances on Mechanism and Drug Discovery of Type-Ⅱ Fatty Acid Biosynthesis Pathway[J]. Acta Chimica Sinica, ;2020, 78(12): 1383-1398. doi: 10.6023/A20070299 shu

Advances on Mechanism and Drug Discovery of Type-Ⅱ Fatty Acid Biosynthesis Pathway

Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Corresponding author: Zhang Liang, liangzhang2014@sjtu.edu.cn
Received Date: 8 July 2020
Available Online: 18 September 2020
Fund Project: Project supported by the Major Research Plan of the National Natural Science Foundation of China (Training Program) (No. 91853118) and Youth Program of National Natural Science Foundation of China (No. 21722802)the Major Research Plan of the National Natural Science Foundation of China(Training Program) 91853118Youth Program of National Natural Science Foundation of China 21722802

Figures(8)

Type-Ⅱ fatty acid biosynthesis pathway (FAS-Ⅱ) is the only essential biosynthesis pathway that producing saturated and unsaturated fatty acids for bacteria and plant cell assembly and cellular metabolism. It utilizes a series of individual enzymes encoded by discrete genes to stepwisely catalyze lipid chain growing carried by the substrate carrier protein-acyl carrier protein (ACP). Due to its indispensable biological role in bacteria growth, as well as the distinct biological regulation mechanisms from mammalian fatty acid biosynthesis (FAS-Ⅰ), the enzymes involved in FAS-Ⅱ have been considered as important anti-pathogenic drug targets for a long time. Hence, investigating the catalysis and dynamic regulation mechanisms of FAS-Ⅱ, developing novel anti-pathogenic drugs against the enzymes involved in FAS-Ⅱ is critical to the field. We here summarize the catalytic mechanism studies and inhibitor discovery work involved in FAS-Ⅱ so far, which may potentially facilitate further understanding of FAS-Ⅱ biological functions as well as antibacterial drug discovery for infectious diseases.
- type-Ⅱ fatty acid biosynthesis pathway (FAS-Ⅱ),
- acyl carrier protein (ACP),
- substrate recognition,
- catalysis regulation,
- inhibitor discovery
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沈阳化工大学材料科学与工程学院沈阳 110142