Citation: Zhou Jiashen, Zhang Lin, Zhang Liang. Advances on Mechanism and Drug Discovery of Type-Ⅱ Fatty Acid Biosynthesis Pathway[J]. Acta Chimica Sinica, ;2020, 78(12): 1383-1398. doi: 10.6023/A20070299 shu

Advances on Mechanism and Drug Discovery of Type-Ⅱ Fatty Acid Biosynthesis Pathway

  • Corresponding author: Zhang Liang, liangzhang2014@sjtu.edu.cn
  • Received Date: 8 July 2020
    Available Online: 18 September 2020

    Fund Project: Project supported by the Major Research Plan of the National Natural Science Foundation of China (Training Program) (No. 91853118) and Youth Program of National Natural Science Foundation of China (No. 21722802)the Major Research Plan of the National Natural Science Foundation of China(Training Program) 91853118Youth Program of National Natural Science Foundation of China 21722802

Figures(8)

  • Type-Ⅱ fatty acid biosynthesis pathway (FAS-Ⅱ) is the only essential biosynthesis pathway that producing saturated and unsaturated fatty acids for bacteria and plant cell assembly and cellular metabolism. It utilizes a series of individual enzymes encoded by discrete genes to stepwisely catalyze lipid chain growing carried by the substrate carrier protein-acyl carrier protein (ACP). Due to its indispensable biological role in bacteria growth, as well as the distinct biological regulation mechanisms from mammalian fatty acid biosynthesis (FAS-Ⅰ), the enzymes involved in FAS-Ⅱ have been considered as important anti-pathogenic drug targets for a long time. Hence, investigating the catalysis and dynamic regulation mechanisms of FAS-Ⅱ, developing novel anti-pathogenic drugs against the enzymes involved in FAS-Ⅱ is critical to the field. We here summarize the catalytic mechanism studies and inhibitor discovery work involved in FAS-Ⅱ so far, which may potentially facilitate further understanding of FAS-Ⅱ biological functions as well as antibacterial drug discovery for infectious diseases.
  • 加载中
    1. [1]

      Smith, S.; Witkowski, A.; Joshi, A. K. Prog. Lipid Res. 2003, 42, 289.

    2. [2]

      White, S. W.; Zheng, J.; Zhang, Y. M.; Rock, C.O. Annu. Rev. Biochem. 2005, 74, 791.

    3. [3]

      Cronan, J. E.; Thomas, J. Methods Enzymol. 2009, 459, 395.

    4. [4]

      Anghel, S. I.; Wahli, W. Cell Res. 2007, 17, 486.

    5. [5]

      Clay, H. B.; Parl, A. K.; Mitchell, S. L.; Singh, L.; Bell, L. N.; Murdock, D. G. PLoS One 2016, 11, e0151171.

    6. [6]

      Nathan, C. J. Exp. Med. 2017, 214, 2175.

    7. [7]

      Sukheja, P.; Kumar, P.; Mittal, N.; Li, S. G.; Singleton, E.; Russo, R.; Perryman, A. L.; Shrestha, R.; Awasthi, D.; Husain, S.; Soteropoulos, P.; Brukh, R.; Connell, N.; Freundlich, J. S.; Alland, D. mBio 2017, 8, e02022.

    8. [8]

      Ballinger, E.; Mosior, J.; Hartman, T.; Burns-Huang, K.; Gold, B.; Morris, R.; Goullieux, L.; Blanc, I.; Vaubourgeix, J.; Lagrange, S.; Fraisse, L.; Sans, S.; Couturier, C.; Bacque, E.; Rhee, K.; Scarry, S. M.; Aube, J.; Yang, G.; Ouerfelli, O.; Schnappinger, D.; Ioerger, T. R.; Engelhart, C. A.; McConnell, J. A.; McAulay, K.; Fay, A.; Roubert, C.; Sacchettini, J.; Nathan, C. Science 2019, 363, 6426.

    9. [9]

      Thorell, K.; Lehours, P.; Vale, F. F. Helicobacter 2017, 22 Suppl 1, e12409.

    10. [10]

      Jimenez-Diaz, L.; Caballero, A.; Perez-Hernandez, N.; Segura, A. Microb. Biotechnol. 2017, 10, 103.

    11. [11]

      Babu, M.; Greenblatt, J. F.; Emili, A.; Strynadka, N. C.; Reithmeier, R. A.; Moraes, T. F. Structure 2010, 18, 1450.

    12. [12]

      Ohlrogge, J.; Savage, L.; Jaworski, J.; Voelker, T.; Postbeittenmiller, D. Arch. Biochem. Biophys. 1995, 317, 185.

    13. [13]

      Chan, D. I.; Chu, B. C.; Lau, C. K.; Hunter, H. N.; Byers, D. M.; Vogel, H. J. J. Biol. Chem. 2010, 285, 30558.

    14. [14]

      Dall'aglio, P.; Arthur, C. J.; Williams, C.; Vasilakis, K.; Maple, H. J.; Crosby, J.; Crump, M. P.; Hadfield, A. T. Biochemistry 2011, 50, 5704.

    15. [15]

      Marcella, A. M.; Culbertson, S. J.; Shogren-Knaak, M. A.; Barb, A. W. J. Mol. Biol. 2017, 429, 3763.

    16. [16]

      Keating, D. H.; Carey, M. R.; Cronan, J. E. J. Biol. Chem. 1995, 270, 22229.

    17. [17]

      Bunkoczi, G.; Pasta, S.; Joshi, A.; Wu, X.; Kavanagh, K. L.; Smith, S.; Oppermann, U. Chem. Biol. 2007, 14, 1243.

    18. [18]

      Joseph-McCarthy, D.; Parris, K.; Huang, A.; Failli, A.; Quagliato, D.; Dushin, E. G.; Novikova, E.; Severina, E.; Tuckman, M.; Petersen, P. J.; Dean, C.; Fritz, C. C.; Meshulam, T.; DeCenzo, M.; Dick, L.; McFadyen, I. J.; Somers, W. S.; Lovering, F.; Gilbert, A. M. J. Med. Chem. 2005, 48, 7960.

    19. [19]

      Chu, M.; Mierzwa, R.; Xu, L.; Yang, S. W.; He, L.; Patel, M.; Stafford, J.; Macinga, D.; Black, T.; Chan, T. M.; Gullo, V. Bioorg. Med. Chem. Lett. 2003, 13, 3827.

    20. [20]

      Ruch, F. E.; Vagelos, P. R. J. Biol. Chem. 1973, 248, 8095.

    21. [21]

      Hong, S. K.; Kim, K. H.; Park, J. K.; Jeong, K. W.; Kim, Y.; Kim, E. E. FEBS Lett. 2010, 584, 1240.

    22. [22]

      Lee, W. C.; Park, J.; Balasubramanian, P. K.; Kim, Y. Biochem. Biophys. Res. Commun. 2018, 505, 208.

    23. [23]

      Li, Z.; Huang, Y.; Ge, J.; Fan, H.; Zhou, X.; Li, S.; Bartlam, M.; Wang, H.; Rao, Z. J. Mol. Biol. 2007, 371, 1075.

    24. [24]

      Keatinge-Clay, A. T.; Shelat, A. A.; Savage, D. F.; Tsai, S.-C.; Miercke, L. J. W.; O'Connell, J. D.; Khosla, C.; Stroud, R. M. Structure 2003, 11, 147.

    25. [25]

      Liu, W.; Han, C.; Hu, L.; Chen, K.; Shen, X.; Jiang, H. FEBS Lett. 2006, 580, 697.

    26. [26]

      Kong, Y. H.; Zhang, L.; Yang, Z. Y.; Han, C.; Hu, L. H.; Jiang, H. L.; Shen, X. Acta Pharmacol. Sin. 2008, 29, 870.

    27. [27]

      Kumar, V.; Sharma, A.; Pratap, S.; Kumar, P. Biochimie 2018, 149, 18.

    28. [28]

      Kumar, V.; Sharma, A.; Pratap, S.; Kumar, P. BBA-Proteins Proteom 2018, 1866, 1131.

    29. [29]

      Li, Y.; Florova, G.; Reynolds, K. A. J. Bacteriol. 2005, 187, 3795.

    30. [30]

      Han, L.; Lobo, S.; Reynolds, K. A. J. Bacteriol. 1998, 180, 4481.

    31. [31]

      Tsay, J. T.; Oh, W.; Larson, T. J.; Jackowski, S.; Rock, C. O. J. Biol. Chem. 1992, 267, 6807.

    32. [32]

      Gajiwala, K. S.; Margosiak, S.; Lu, J.; Cortez, J.; Su, Y.; Nie, Z.; Appelt, K. FEBS Lett. 2009, 583, 2939.

    33. [33]

      Yuan, Y.; Sachdeva, M.; Leeds, J. A.; Meredith, T. C. J. Bacteriol. 2012, 194, 5171.

    34. [34]

      Milligan, J. C.; Lee, D. J.; Jackson, D. R.; Schaub, A. J.; Beld, J.; Barajas, J. F.; Hale, J. J.; Luo, R.; Burkart, M. D.; Tsai, S. C. Nat. Chem. Biol. 2019, 15, 669.

    35. [35]

      Mindrebo, J. T.; Patel, A.; Kim, W. E.; Davis, T. D.; Chen, A.; Bartholow, T. G.; La Clair, J. J.; McCammon, J. A.; Noel, J. P.; Burkart, M. D. Nat. Commun. 2020, 11, 1727.

    36. [36]

      Nanson, J. D.; Himiari, Z.; Swarbrick, C. M.; Forwood, J. K. Sci. Rep. 2015, 5, 14797.

    37. [37]

      Price, A. C.; Choi, K. H.; Heath, R. J.; Li, Z.; White, S. W.; Rock, C. O. J. Biol. Chem. 2001, 276, 6551.

    38. [38]

      Wang, J.; Kodali, S.; Lee, S. H.; Galgoci, A.; Painter, R.; Dorso, K.; Racine, F.; Motyl, M.; Hernandez, L.; Tinney, E.; Colletti, S. L.; Herath, K.; Cummings, R.; Salazar, O.; González, I.; Basilio, A.; Vicente, F.; Genilloud, O.; Pelaez, F.; Jayasuriya, H.; Young, K.; Cully, D. F.; Singh, S. B. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 7612.

    39. [39]

      Daines, R. A.; Pendrak, I.; Sham, K.; Van Aller, G. S.; Konstantinidis, A. K.; Lonsdale, J. T.; Janson, C. A.; Qiu, X.; Brandt, M.; Khandekar, S. S.; Silverman, C.; Head, M. S. J. Med. Chem. 2003, 46, 5.

    40. [40]

      McKinney, D. C.; Eyermann, C. J.; Gu, R. F.; Hu, J.; Kazmirski, S. L.; Lahiri, S. D.; McKenzie, A. R.; Shapiro, A. B.; Breault, G. ACS Infect. Dis. 2016, 2, 456.

    41. [41]

      Wang, J.; Soisson, S. M.; Young, K.; Shoop, W.; Kodali, S.; Galgoci, A.; Painter, R.; Parthasarathy, G.; Tang, Y. S.; Cummings, R.; Ha, S.; Dorso, K.; Motyl, M.; Jayasuriya, H.; Ondeyka, J.; Herath, K.; Zhang, C.; Hernandez, L.; Allocco, J.; Basilio, A.; Tormo, J. R.; Genilloud, O.; Vicente, F.; Pelaez, F.; Colwell, L.; Lee, S. H.; Michael, B.; Felcetto, T.; Gill, C.; Silver, L. L.; Hermes, J. D.; Bartizal, K.; Barrett, J.; Schmatz, D.; Becker, J. W.; Cully, D.; Singh, S. B. Nature 2006, 441, 358.

    42. [42]

      Zheng, Z.; Parsons, J. B.; Tangallapally, R.; Zhang, W.; Rock, C. O.; Lee, R. E. Bioorg. Med. Chem. Lett. 2014, 24, 2585.

    43. [43]

      Kallberg, Y.; Oppermann, U.; Jornvall, H.; Persson, B. Eur. J. Biochem. 2002, 269, 4409.

    44. [44]

      Hou, J.; Zheng, H.; Chruszcz, M.; Zimmerman, M. D.; Shumilin, I. A.; Osinski, T.; Demas, M.; Grimshaw, S.; Minor, W. J. Bacteriol. 2016, 198, 463.

    45. [45]

      Price, A. C.; Zhang, Y.-M.; Rock, C. O.; White, S. W. Biochemistry 2001, 40, 12772.

    46. [46]

      Silva, R. G.; Rosado, L. A.; Santos, D. S.; Basso, L. A. Arch. Biochem. Biophys. 2008, 471, 1.

    47. [47]

      Price, A. C.; Zhang, Y. M.; Rock, C. O.; White, S. W. Structure 2004, 12, 417.

    48. [48]

      Cohen-Gonsaud, M.; Ducasse-Cabanot, S.; Quemard, A.; Labesse, G. Proteins 2005, 60, 392.

    49. [49]

      Cukier, C. D.; Hope, A. G.; Elamin, A. A.; Moynie, L.; Schnell, R.; Schach, S.; Kneuper, H.; Singh, M.; Naismith, J. H.; Lindqvist, Y.; Gray, D. W.; Schneider, G. ACS Chem. Biol. 2013, 8, 2518.

    50. [50]

      Lai, C. Y.; Cronan, J. E. J. Bacteriol. 2004, 186, 1869.

    51. [51]

      Sohn, M.-J.; Zheng, C.-J.; Kim, W.-G. J. Antibiot. 2008, 61, 687.

    52. [52]

      Wickramasinghe, S. R.; Inglis, K. A.; Urch, J. E.; Muller, S.; van Aalten, D. M.; Fairlamb, A. H. Biochem. J. 2006, 393, 447.

    53. [53]

      Tasdemir, D.; Lack, G.; Brun, R.; Rüedi, P.; Scapozza, L.; Perozzo, R. J. Med. Chem. 2006, 49, 3345.

    54. [54]

      Zhang, F.; Luo, S. Y.; Ye, Y. B.; Zhao, W. H.; Sun, X. G.; Wang, Z. Q.; Li, R.; Sun, Y. H.; Tian, W. X.; Zhang, Y. X. Biotechnol. Appl. Biochem. 2008, 51, 73.

    55. [55]

      Zeng, D.; Zhao, J.; Chung, H. S.; Guan, Z.; Raetz, C. R.; Zhou, P. J. Biol. Chem. 2013, 288, 5475.

    56. [56]

      Swarnamukhi, P. L.; Sharma, S. K.; Bajaj, P.; Surolia, N.; Surolia, A.; Suguna, K. FEBS Lett. 2006, 580, 2653.

    57. [57]

      Zhang, L.; Xiao, J.; Xu, J.; Fu, T.; Cao, Z.; Zhu, L.; Chen, H. Z.; Shen, X.; Jiang, H.; Zhang, L. Cell Res. 2016, 26, 1330.

    58. [58]

      Shen, S.; Hang, X.; Zhuang, J.; Zhang, L.; Bi, H.; Zhang, L. Int. J. Biol. Macromol. 2019, 128, 5.

    59. [59]

      Dodge, G. J.; Patel, A.; Jaremko, K. L.; McCammon, J. A.; Smith, J. L.; Burkart, M. D. Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 6775.

    60. [60]

      Moynie, L.; Leckie, S. M.; McMahon, S. A.; Duthie, F. G.; Koehnke, A.; Taylor, J. W.; Alphey, M. S.; Brenk, R.; Smith, A. D.; Naismith, J. H. J. Mol. Biol. 2013, 425, 365.

    61. [61]

      Heath, R. J.; Rock, C. O. J. Biol. Chem. 1996, 271, 27795.

    62. [62]

      Nguyen, C.; Haushalter, R. W.; Lee, D. J.; Markwick, P. R.; Bruegger, J.; Caldara-Festin, G.; Finzel, K.; Jackson, D. R.; Ishikawa, F.; O'Dowd, B.; McCammon, J. A.; Opella, S. J.; Tsai, S. C.; Burkart, M. D. Nature 2014, 505, 427.

    63. [63]

      Bi, H.; Zhu, L.; Jia, J.; Zeng, L.; Cronan, J. E. Cell Chem. Biol. 2016, 23, 1480.

    64. [64]

      Wang, H.; Cronan, J. E. J. Biol. Chem. 2004, 279, 34489.

    65. [65]

      Bi, H.; Wang, H.; Cronan, J. E. Chem. Biol. 2013, 20, 1157.

    66. [66]

      Marrakchi, H.; Choi, K. H.; Rock, C. O. J. Biol. Chem. 2002, 277, 44809.

    67. [67]

      Aguilar, P. S.; Cronan, J. E.; de Mendoza, D. J. Bacteriol. 1998, 180, 2194.

    68. [68]

      Sharma, S. K.; Kapoor, M.; Ramya, T. N.; Kumar, S.; Kumar, G.; Modak, R.; Sharma, S.; Surolia, N.; Surolia, A. J. Biol. Chem. 2003, 278, 45661.

    69. [69]

      Zhang, L.; Liu, W.; Hu, T.; Du, L.; Luo, C.; Chen, K.; Shen, X.; Jiang, H. J. Biol. Chem. 2008, 283, 5370.

    70. [70]

      He, L.; Zhang, L.; Liu, X.; Li, X.; Zheng, M.; Li, H.; Yu, K.; Chen, K.; Shen, X.; Jiang, H.; Liu, H. J. Med. Chem. 2009, 52, 2465.

    71. [71]

      Zhang, L.; Kong, Y.; Wu, D.; Zhang, H.; Wu, J.; Chen, J.; Ding, J.; Hu, L.; Jiang, H.; Shen, X. Protein Sci. 2008, 17, 1971.

    72. [72]

      Chen, J.; Zhang, L.; Zhang, Y.; Zhang, H.; Du, J.; Ding, J.; Guo, Y.; Jiang, H.; Shen, X. BMC Microbiol. 2009, 9, 91.

    73. [73]

      McGillick, B. E.; Kumaran, D.; Vieni, C.; Swaminathan, S. Biochemistry 2016, 55, 1091.

    74. [74]

      Leesong, M.; Henderson, B. S.; Gillig, J. R.; Schwab, J. M.; Smith, J. L. Structure 1996, 4, 253.

    75. [75]

      Moynie, L.; Hope, A. G.; Finzel, K.; Schmidberger, J.; Leckie, S. M.; Schneider, G.; Burkart, M. D.; Smith, A. D.; Gray, D. W.; Naismith, J. H. J. Mol. Biol. 2016, 428, 108.

    76. [76]

      Kim, H. T.; Kim, S.; Na, B. K.; Chung, J.; Hwang, E.; Hwang, K. Y. Biochem. Biophys. Res. Commun. 2017, 493, 28.

    77. [77]

      Rafi, S.; Novichenok, P.; Kolappan, S.; Stratton, C. F.; Rawat, R.; Kisker, C.; Simmerling, C.; Tonge, P. J. J. Biol. Chem. 2006, 281, 39285.

    78. [78]

      Kim, K. H.; Ha, B. H.; Kim, S. J.; Hong, S. K.; Hwang, K. Y.; Kim, E. E. J. Mol. Biol. 2011, 406, 403.

    79. [79]

      Neckles, C.; Pschibul, A.; Lai, C. T.; Hirschbeck, M.; Kuper, J.; Davoodi, S.; Zou, J.; Liu, N.; Pan, P.; Shah, S.; Daryaee, F.; Bommineni, G. R.; Lai, C.; Simmerling, C.; Kisker, C.; Tonge, P. J. Biochemistry 2016, 55, 2992.

    80. [80]

      Li, H.; Zhang, X.; Bi, L.; He, J.; Jiang, T. PLoS One 2011, 6, e26743.

    81. [81]

      Kim, S. H.; Khan, R.; Choi, K.; Lee, S. W.; Rhee, S. FEBS J. 2020, 281, 4710.

    82. [82]

      Saito, J.; Yamada, M.; Watanabe, T.; Iida, M.; Kitagawa, H.; Takahata, S.; Ozawa, T.; Takeuchi, Y.; Ohsawa, F. Protein Sci. 2008, 17, 691.

    83. [83]

      Qiu, X.; Abdel-Meguid, S. S.; Janson, C. A.; Court, R. I.; Smyth, M. G.; Payne, D. J. Protein Sci. 1999, 8, 2529.

    84. [84]

      Miller, W. H.; Seefeld, M. A.; Newlander, K. A.; Uzinskas, I. N.; Burgess, W. J.; Heerding, D. A.; Yuan, C. C. K.; Head, M. S.; Payne, D. J.; Rittenhouse, S. F.; Moore, T. D.; Pearson, S. C.; Berry, V.; DeWolf, W. E.; Keller, P. M.; Polizzi, B. J.; Qiu, X.; Janson, C. A.; Huffman, W. F. J. Med. Chem. 2002, 45, 3246.

    85. [85]

      Seefeld, M. A.; Miller, W. H.; Newlander, K. A.; Burgess, W. J.; DeWolf, W. E.; Elkins, P. A.; Head, M. S.; Jakas, D. R.; Janson, C. A.; Keller, P. M.; Manley, P. J.; Moore, T. D.; Payne, D. J.; Pearson, S.; Polizzi, B. J.; Qiu, X.; Rittenhouse, S. F.; Uzinskas, I. N.; Wallis, N. G.; Huffman, W. F. J. Med. Chem. 2003, 46, 1627.

    86. [86]

      Heerding, D. A.; Chan, G.; DeWolf, W. E.; Fosberry, A. P.; Janson, C. A.; Jaworski, D. D.; McManus, E.; Miller, W. H.; Moore, T. D.; Payne, D. J.; Qiu, X.; Rittenhouse, S. F.; Slater-Radosti, C.; Smith, W.; Takata, D. T.; Vaidya, K. S.; Yuan, C. C. K.; Huffman, W. F. Bioorg. Med. Chem. Lett. 2001, 11, 2061.

    87. [87]

      Seefeld, M. A.; Miller, W. H.; Newlander, K. A.; Burgess, W. J.; Payne, D. J.; Rittenhouse, S. F.; Moore, T. D.; DeWolf, W. E.; Keller, P. M.; Qiu, X.; Janson, C. A.; Vaidya, K.; Fosberry, A. P.; Smyth, M. G.; Jaworski, D. D.; Slater-Radosti, C.; Huffman, W. F. Bioorg. Med. Chem. Lett. 2001, 11, 2241.

    88. [88]

      Ramnauth, J.; Surman, M. D.; Sampson, P. B.; Forrest, B.; Wilson, J.; Freeman, E.; Manning, D. D.; Martin, F.; Toro, A.; Domagala, M.; Awrey, D. E.; Bardouniotis, E.; Kaplan, N.; Berman, J.; Pauls, H. W. Bioorg. Med. Chem. Lett. 2009, 19, 5359.

    89. [89]

      Sampson, P. B.; Picard, C.; Handerson, S.; McGrath, T. E.; Domagala, M.; Leeson, A.; Romanov, V.; Awrey, D. E.; Thambipillai, D.; Bardouniotis, E.; Kaplan, N.; Berman, J. M.; Pauls, H. W. Bioorg. Med. Chem. Lett. 2009, 19, 5355.

    90. [90]

      Fage, C. D.; Lathouwers, T.; Vanmeert, M.; Gao, L. J.; Vrancken, K.; Lammens, E. M.; Weir, A. N. M.; Degroote, R.; Cuppens, H.; Kosol, S.; Simpson, T. J.; Crump, M. P.; Willis, C. L.; Herdewijn, P.; Lescrinier, E.; Lavigne, R.; Anne, J.; Masschelein, J. Angew. Chem. Int. Ed. 2020, 59, 10549.

    91. [91]

      Karlowsky, J. A.; Laing, N. M.; Baudry, T.; Kaplan, N.; Vaughan, D.; Hoban, D. J.; Zhanel, G. G. Antimicrob. Agents Chemother. 2007, 51, 1580.

    92. [92]

      Hafkin, B.; Kaplan, N.; Murphy, B. Antimicrob. Agents Chemother. 2015, 60, 1695.

    93. [93]

      Parker, E. N.; Drown, B. S.; Geddes, E. J.; Lee, H. Y.; Ismail, N.; Lau, G. W.; Hergenrother, P. J. Nat. Microbiol. 2020, 5, 67.

    94. [94]

      Ozawa, T.; Kitagawa, H.; Yamamoto, Y.; Takahata, S.; Iida, M.; Osaki, Y.; Yamada, K. Bioorg. Med. Chem. Lett. 2007, 15, 7325.

    95. [95]

      Jones, J. A.; Prior, A. M.; Marreddy, R. K. R.; Wahrmund, R. D.; Hurdle, J. G.; Sun, D.; Hevener, K. E. ACS Chem. Biol. 2019, 14, 1528.

    96. [96]

      Yu, Y. H.; Ma, J. R.; Wang, H. H. J. Microbiol. 2016, 4, 76 (in Chinese).

  • 加载中
    1. [1]

      CCS Chemistry | 超分子活化底物自由基促进高效选择性光催化氧化

      . CCS Chemistry, 2025, 7(10.31635/ccschem.025.202405229): -.

    2. [2]

      Kexin Dong Chuqi Shen Ruyu Yan Yanping Liu Chunqiang Zhuang Shijie Li . Integration of Plasmonic Effect and S-Scheme Heterojunction into Ag/Ag3PO4/C3N5 Photocatalyst for Boosted Photocatalytic Levofloxacin Degradation. Acta Physico-Chimica Sinica, 2024, 40(10): 2310013-. doi: 10.3866/PKU.WHXB202310013

    3. [3]

      Hong CAIJiewen WUJingyun LILixian CHENSiqi XIAODan LI . Synthesis of a zinc-cobalt bimetallic adenine metal-organic framework for the recognition of sulfur-containing amino acids. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 114-122. doi: 10.11862/CJIC.20240382

    4. [4]

      Yikai Wang Xiaolin Jiang Haoming Song Nan Wei Yifan Wang Xinjun Xu Cuihong Li Hao Lu Yahui Liu Zhishan Bo . 氰基修饰的苝二酰亚胺衍生物作为膜厚不敏感型阴极界面材料用于高效有机太阳能电池. Acta Physico-Chimica Sinica, 2025, 41(3): 2406007-. doi: 10.3866/PKU.WHXB202406007

    5. [5]

      Xingyang LITianju LIUYang GAODandan ZHANGYong ZHOUMeng PAN . A superior methanol-to-propylene catalyst: Construction via synergistic regulation of pore structure and acidic property of high-silica ZSM-5 zeolite. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1279-1289. doi: 10.11862/CJIC.20240026

    6. [6]

      Hailian Tang Siyuan Chen Qiaoyun Liu Guoyi Bai Botao Qiao Fei Liu . Stabilized Rh/hydroxyapatite Catalyst for Furfuryl Alcohol Hydrogenation: Application of Oxidative Strong Metal-Support Interactions in Reducing Conditions. Acta Physico-Chimica Sinica, 2025, 41(4): 100036-. doi: 10.3866/PKU.WHXB202408004

    7. [7]

      Jiapei Zou Junyang Zhang Xuming Wu Cong Wei Simin Fang Yuxi Wang . A Comprehensive Experiment Based on Electrocatalytic Nitrate Reduction into Ammonia: Synthesis, Characterization, Performance Exploration, and Applicable Design of Copper-based Catalysts. University Chemistry, 2024, 39(6): 373-382. doi: 10.3866/PKU.DXHX202312081

    8. [8]

      Bing WEIJianfan ZHANGZhe CHEN . Research progress in fine tuning of bimetallic nanocatalysts for electrocatalytic carbon dioxide reduction. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 425-439. doi: 10.11862/CJIC.20240201

    9. [9]

      Lirui Shen Kun Liu Ying Yang Dongwan Li Wengui Chang . Synthesis and Application of Decanedioic Acid-N-Hydroxysuccinimide Ester: Exploration of Teaching Reform in Comprehensive Applied Chemistry Experiment. University Chemistry, 2024, 39(8): 212-220. doi: 10.3866/PKU.DXHX202312035

    10. [10]

      Ke Li Chuang Liu Jingping Li Guohong Wang Kai Wang . 钛酸铋/氮化碳无机有机复合S型异质结纯水光催化产过氧化氢. Acta Physico-Chimica Sinica, 2024, 40(11): 2403009-. doi: 10.3866/PKU.WHXB202403009

    11. [11]

      Jiaxuan Zuo Kun Zhang Jing Wang Xifei Li . 锂离子电池Ni-Co-Mn基正极材料前驱体的形核调控及机制. Acta Physico-Chimica Sinica, 2025, 41(1): 2404042-. doi: 10.3866/PKU.WHXB202404042

    12. [12]

      Jiahui YUJixian DONGYutong ZHAOFuping ZHAOBo GEXipeng PUDafeng ZHANG . The morphology control and full-spectrum photodegradation tetracycline performance of microwave-hydrothermal synthesized BiVO4:Yb3+,Er3+ photocatalyst. Journal of Fuel Chemistry and Technology, 2025, 53(3): 348-359. doi: 10.1016/S1872-5813(24)60514-1

    13. [13]

      Yi DINGPeiyu LIAOJianhua JIAMingliang TONG . Structure and photoluminescence modulation of silver(Ⅰ)-tetra(pyridin-4-yl)ethene metal-organic frameworks by substituted benzoates. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 141-148. doi: 10.11862/CJIC.20240393

    14. [14]

      Yang Xia Kangyan Zhang Heng Yang Lijuan Shi Qun Yi . 构建双通道路径增强iCOF/Bi2O3 S型异质结在纯水体系中光催化合成H2O2性能. Acta Physico-Chimica Sinica, 2024, 40(11): 2407012-. doi: 10.3866/PKU.WHXB202407012

    15. [15]

      Minna Ma Yujin Ouyang Yuan Wu Mingwei Yuan Lijuan Yang . Green Synthesis of Medical Chemiluminescence Reagents by Photocatalytic Oxidation. University Chemistry, 2024, 39(5): 134-143. doi: 10.3866/PKU.DXHX202310093

    16. [16]

      Ran Yu Chen Hu Ruili Guo Ruonan Liu Lixing Xia Cenyu Yang Jianglan Shui . 杂多酸H3PW12O40高效催化MgH2储氢. Acta Physico-Chimica Sinica, 2025, 41(1): 2308032-. doi: 10.3866/PKU.WHXB202308032

    17. [17]

      Yuanyin Cui Jinfeng Zhang Hailiang Chu Lixian Sun Kai Dai . Rational Design of Bismuth Based Photocatalysts for Solar Energy Conversion. Acta Physico-Chimica Sinica, 2024, 40(12): 2405016-. doi: 10.3866/PKU.WHXB202405016

    18. [18]

      Dan Li Hui Xin Xiaofeng Yi . Comprehensive Experimental Design on Ni-based Catalyst for Biofuel Production. University Chemistry, 2024, 39(8): 204-211. doi: 10.3866/PKU.DXHX202312046

    19. [19]

      Juntao Yan Liang Wei . 2D S-Scheme Heterojunction Photocatalyst. Acta Physico-Chimica Sinica, 2024, 40(10): 2312024-. doi: 10.3866/PKU.WHXB202312024

    20. [20]

      Peiran ZHAOYuqian LIUCheng HEChunying DUAN . A functionalized Eu3+ metal-organic framework for selective fluorescent detection of pyrene. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 713-724. doi: 10.11862/CJIC.20230355

Metrics
  • PDF Downloads(178)
  • Abstract views(7824)
  • HTML views(2107)

通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Address:Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888
Powered By info@rhhz.net

/

DownLoad:  Full-Size Img  PowerPoint
Return