Advances on Mechanism and Drug Discovery of Type-Ⅱ Fatty Acid Biosynthesis Pathway
- Corresponding author: Zhang Liang, liangzhang2014@sjtu.edu.cn
Citation:
Zhou Jiashen, Zhang Lin, Zhang Liang. Advances on Mechanism and Drug Discovery of Type-Ⅱ Fatty Acid Biosynthesis Pathway[J]. Acta Chimica Sinica,
;2020, 78(12): 1383-1398.
doi:
10.6023/A20070299
Smith, S.; Witkowski, A.; Joshi, A. K. Prog. Lipid Res. 2003, 42, 289.
White, S. W.; Zheng, J.; Zhang, Y. M.; Rock, C.O. Annu. Rev. Biochem. 2005, 74, 791.
Cronan, J. E.; Thomas, J. Methods Enzymol. 2009, 459, 395.
Anghel, S. I.; Wahli, W. Cell Res. 2007, 17, 486.
Clay, H. B.; Parl, A. K.; Mitchell, S. L.; Singh, L.; Bell, L. N.; Murdock, D. G. PLoS One 2016, 11, e0151171.
Nathan, C. J. Exp. Med. 2017, 214, 2175.
Sukheja, P.; Kumar, P.; Mittal, N.; Li, S. G.; Singleton, E.; Russo, R.; Perryman, A. L.; Shrestha, R.; Awasthi, D.; Husain, S.; Soteropoulos, P.; Brukh, R.; Connell, N.; Freundlich, J. S.; Alland, D. mBio 2017, 8, e02022.
Ballinger, E.; Mosior, J.; Hartman, T.; Burns-Huang, K.; Gold, B.; Morris, R.; Goullieux, L.; Blanc, I.; Vaubourgeix, J.; Lagrange, S.; Fraisse, L.; Sans, S.; Couturier, C.; Bacque, E.; Rhee, K.; Scarry, S. M.; Aube, J.; Yang, G.; Ouerfelli, O.; Schnappinger, D.; Ioerger, T. R.; Engelhart, C. A.; McConnell, J. A.; McAulay, K.; Fay, A.; Roubert, C.; Sacchettini, J.; Nathan, C. Science 2019, 363, 6426.
Thorell, K.; Lehours, P.; Vale, F. F. Helicobacter 2017, 22 Suppl 1, e12409.
Jimenez-Diaz, L.; Caballero, A.; Perez-Hernandez, N.; Segura, A. Microb. Biotechnol. 2017, 10, 103.
Babu, M.; Greenblatt, J. F.; Emili, A.; Strynadka, N. C.; Reithmeier, R. A.; Moraes, T. F. Structure 2010, 18, 1450.
Ohlrogge, J.; Savage, L.; Jaworski, J.; Voelker, T.; Postbeittenmiller, D. Arch. Biochem. Biophys. 1995, 317, 185.
Chan, D. I.; Chu, B. C.; Lau, C. K.; Hunter, H. N.; Byers, D. M.; Vogel, H. J. J. Biol. Chem. 2010, 285, 30558.
Dall'aglio, P.; Arthur, C. J.; Williams, C.; Vasilakis, K.; Maple, H. J.; Crosby, J.; Crump, M. P.; Hadfield, A. T. Biochemistry 2011, 50, 5704.
Marcella, A. M.; Culbertson, S. J.; Shogren-Knaak, M. A.; Barb, A. W. J. Mol. Biol. 2017, 429, 3763.
Keating, D. H.; Carey, M. R.; Cronan, J. E. J. Biol. Chem. 1995, 270, 22229.
Bunkoczi, G.; Pasta, S.; Joshi, A.; Wu, X.; Kavanagh, K. L.; Smith, S.; Oppermann, U. Chem. Biol. 2007, 14, 1243.
Joseph-McCarthy, D.; Parris, K.; Huang, A.; Failli, A.; Quagliato, D.; Dushin, E. G.; Novikova, E.; Severina, E.; Tuckman, M.; Petersen, P. J.; Dean, C.; Fritz, C. C.; Meshulam, T.; DeCenzo, M.; Dick, L.; McFadyen, I. J.; Somers, W. S.; Lovering, F.; Gilbert, A. M. J. Med. Chem. 2005, 48, 7960.
Chu, M.; Mierzwa, R.; Xu, L.; Yang, S. W.; He, L.; Patel, M.; Stafford, J.; Macinga, D.; Black, T.; Chan, T. M.; Gullo, V. Bioorg. Med. Chem. Lett. 2003, 13, 3827.
Ruch, F. E.; Vagelos, P. R. J. Biol. Chem. 1973, 248, 8095.
Hong, S. K.; Kim, K. H.; Park, J. K.; Jeong, K. W.; Kim, Y.; Kim, E. E. FEBS Lett. 2010, 584, 1240.
Lee, W. C.; Park, J.; Balasubramanian, P. K.; Kim, Y. Biochem. Biophys. Res. Commun. 2018, 505, 208.
Li, Z.; Huang, Y.; Ge, J.; Fan, H.; Zhou, X.; Li, S.; Bartlam, M.; Wang, H.; Rao, Z. J. Mol. Biol. 2007, 371, 1075.
Keatinge-Clay, A. T.; Shelat, A. A.; Savage, D. F.; Tsai, S.-C.; Miercke, L. J. W.; O'Connell, J. D.; Khosla, C.; Stroud, R. M. Structure 2003, 11, 147.
Liu, W.; Han, C.; Hu, L.; Chen, K.; Shen, X.; Jiang, H. FEBS Lett. 2006, 580, 697.
Kong, Y. H.; Zhang, L.; Yang, Z. Y.; Han, C.; Hu, L. H.; Jiang, H. L.; Shen, X. Acta Pharmacol. Sin. 2008, 29, 870.
Kumar, V.; Sharma, A.; Pratap, S.; Kumar, P. Biochimie 2018, 149, 18.
Kumar, V.; Sharma, A.; Pratap, S.; Kumar, P. BBA-Proteins Proteom 2018, 1866, 1131.
Li, Y.; Florova, G.; Reynolds, K. A. J. Bacteriol. 2005, 187, 3795.
Han, L.; Lobo, S.; Reynolds, K. A. J. Bacteriol. 1998, 180, 4481.
Tsay, J. T.; Oh, W.; Larson, T. J.; Jackowski, S.; Rock, C. O. J. Biol. Chem. 1992, 267, 6807.
Gajiwala, K. S.; Margosiak, S.; Lu, J.; Cortez, J.; Su, Y.; Nie, Z.; Appelt, K. FEBS Lett. 2009, 583, 2939.
Yuan, Y.; Sachdeva, M.; Leeds, J. A.; Meredith, T. C. J. Bacteriol. 2012, 194, 5171.
Milligan, J. C.; Lee, D. J.; Jackson, D. R.; Schaub, A. J.; Beld, J.; Barajas, J. F.; Hale, J. J.; Luo, R.; Burkart, M. D.; Tsai, S. C. Nat. Chem. Biol. 2019, 15, 669.
Mindrebo, J. T.; Patel, A.; Kim, W. E.; Davis, T. D.; Chen, A.; Bartholow, T. G.; La Clair, J. J.; McCammon, J. A.; Noel, J. P.; Burkart, M. D. Nat. Commun. 2020, 11, 1727.
Nanson, J. D.; Himiari, Z.; Swarbrick, C. M.; Forwood, J. K. Sci. Rep. 2015, 5, 14797.
Price, A. C.; Choi, K. H.; Heath, R. J.; Li, Z.; White, S. W.; Rock, C. O. J. Biol. Chem. 2001, 276, 6551.
Wang, J.; Kodali, S.; Lee, S. H.; Galgoci, A.; Painter, R.; Dorso, K.; Racine, F.; Motyl, M.; Hernandez, L.; Tinney, E.; Colletti, S. L.; Herath, K.; Cummings, R.; Salazar, O.; González, I.; Basilio, A.; Vicente, F.; Genilloud, O.; Pelaez, F.; Jayasuriya, H.; Young, K.; Cully, D. F.; Singh, S. B. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 7612.
Daines, R. A.; Pendrak, I.; Sham, K.; Van Aller, G. S.; Konstantinidis, A. K.; Lonsdale, J. T.; Janson, C. A.; Qiu, X.; Brandt, M.; Khandekar, S. S.; Silverman, C.; Head, M. S. J. Med. Chem. 2003, 46, 5.
McKinney, D. C.; Eyermann, C. J.; Gu, R. F.; Hu, J.; Kazmirski, S. L.; Lahiri, S. D.; McKenzie, A. R.; Shapiro, A. B.; Breault, G. ACS Infect. Dis. 2016, 2, 456.
Wang, J.; Soisson, S. M.; Young, K.; Shoop, W.; Kodali, S.; Galgoci, A.; Painter, R.; Parthasarathy, G.; Tang, Y. S.; Cummings, R.; Ha, S.; Dorso, K.; Motyl, M.; Jayasuriya, H.; Ondeyka, J.; Herath, K.; Zhang, C.; Hernandez, L.; Allocco, J.; Basilio, A.; Tormo, J. R.; Genilloud, O.; Vicente, F.; Pelaez, F.; Colwell, L.; Lee, S. H.; Michael, B.; Felcetto, T.; Gill, C.; Silver, L. L.; Hermes, J. D.; Bartizal, K.; Barrett, J.; Schmatz, D.; Becker, J. W.; Cully, D.; Singh, S. B. Nature 2006, 441, 358.
Zheng, Z.; Parsons, J. B.; Tangallapally, R.; Zhang, W.; Rock, C. O.; Lee, R. E. Bioorg. Med. Chem. Lett. 2014, 24, 2585.
Kallberg, Y.; Oppermann, U.; Jornvall, H.; Persson, B. Eur. J. Biochem. 2002, 269, 4409.
Hou, J.; Zheng, H.; Chruszcz, M.; Zimmerman, M. D.; Shumilin, I. A.; Osinski, T.; Demas, M.; Grimshaw, S.; Minor, W. J. Bacteriol. 2016, 198, 463.
Price, A. C.; Zhang, Y.-M.; Rock, C. O.; White, S. W. Biochemistry 2001, 40, 12772.
Silva, R. G.; Rosado, L. A.; Santos, D. S.; Basso, L. A. Arch. Biochem. Biophys. 2008, 471, 1.
Price, A. C.; Zhang, Y. M.; Rock, C. O.; White, S. W. Structure 2004, 12, 417.
Cohen-Gonsaud, M.; Ducasse-Cabanot, S.; Quemard, A.; Labesse, G. Proteins 2005, 60, 392.
Cukier, C. D.; Hope, A. G.; Elamin, A. A.; Moynie, L.; Schnell, R.; Schach, S.; Kneuper, H.; Singh, M.; Naismith, J. H.; Lindqvist, Y.; Gray, D. W.; Schneider, G. ACS Chem. Biol. 2013, 8, 2518.
Lai, C. Y.; Cronan, J. E. J. Bacteriol. 2004, 186, 1869.
Sohn, M.-J.; Zheng, C.-J.; Kim, W.-G. J. Antibiot. 2008, 61, 687.
Wickramasinghe, S. R.; Inglis, K. A.; Urch, J. E.; Muller, S.; van Aalten, D. M.; Fairlamb, A. H. Biochem. J. 2006, 393, 447.
Tasdemir, D.; Lack, G.; Brun, R.; Rüedi, P.; Scapozza, L.; Perozzo, R. J. Med. Chem. 2006, 49, 3345.
Zhang, F.; Luo, S. Y.; Ye, Y. B.; Zhao, W. H.; Sun, X. G.; Wang, Z. Q.; Li, R.; Sun, Y. H.; Tian, W. X.; Zhang, Y. X. Biotechnol. Appl. Biochem. 2008, 51, 73.
Zeng, D.; Zhao, J.; Chung, H. S.; Guan, Z.; Raetz, C. R.; Zhou, P. J. Biol. Chem. 2013, 288, 5475.
Swarnamukhi, P. L.; Sharma, S. K.; Bajaj, P.; Surolia, N.; Surolia, A.; Suguna, K. FEBS Lett. 2006, 580, 2653.
Zhang, L.; Xiao, J.; Xu, J.; Fu, T.; Cao, Z.; Zhu, L.; Chen, H. Z.; Shen, X.; Jiang, H.; Zhang, L. Cell Res. 2016, 26, 1330.
Shen, S.; Hang, X.; Zhuang, J.; Zhang, L.; Bi, H.; Zhang, L. Int. J. Biol. Macromol. 2019, 128, 5.
Dodge, G. J.; Patel, A.; Jaremko, K. L.; McCammon, J. A.; Smith, J. L.; Burkart, M. D. Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 6775.
Moynie, L.; Leckie, S. M.; McMahon, S. A.; Duthie, F. G.; Koehnke, A.; Taylor, J. W.; Alphey, M. S.; Brenk, R.; Smith, A. D.; Naismith, J. H. J. Mol. Biol. 2013, 425, 365.
Heath, R. J.; Rock, C. O. J. Biol. Chem. 1996, 271, 27795.
Nguyen, C.; Haushalter, R. W.; Lee, D. J.; Markwick, P. R.; Bruegger, J.; Caldara-Festin, G.; Finzel, K.; Jackson, D. R.; Ishikawa, F.; O'Dowd, B.; McCammon, J. A.; Opella, S. J.; Tsai, S. C.; Burkart, M. D. Nature 2014, 505, 427.
Bi, H.; Zhu, L.; Jia, J.; Zeng, L.; Cronan, J. E. Cell Chem. Biol. 2016, 23, 1480.
Wang, H.; Cronan, J. E. J. Biol. Chem. 2004, 279, 34489.
Bi, H.; Wang, H.; Cronan, J. E. Chem. Biol. 2013, 20, 1157.
Marrakchi, H.; Choi, K. H.; Rock, C. O. J. Biol. Chem. 2002, 277, 44809.
Aguilar, P. S.; Cronan, J. E.; de Mendoza, D. J. Bacteriol. 1998, 180, 2194.
Sharma, S. K.; Kapoor, M.; Ramya, T. N.; Kumar, S.; Kumar, G.; Modak, R.; Sharma, S.; Surolia, N.; Surolia, A. J. Biol. Chem. 2003, 278, 45661.
Zhang, L.; Liu, W.; Hu, T.; Du, L.; Luo, C.; Chen, K.; Shen, X.; Jiang, H. J. Biol. Chem. 2008, 283, 5370.
He, L.; Zhang, L.; Liu, X.; Li, X.; Zheng, M.; Li, H.; Yu, K.; Chen, K.; Shen, X.; Jiang, H.; Liu, H. J. Med. Chem. 2009, 52, 2465.
Zhang, L.; Kong, Y.; Wu, D.; Zhang, H.; Wu, J.; Chen, J.; Ding, J.; Hu, L.; Jiang, H.; Shen, X. Protein Sci. 2008, 17, 1971.
Chen, J.; Zhang, L.; Zhang, Y.; Zhang, H.; Du, J.; Ding, J.; Guo, Y.; Jiang, H.; Shen, X. BMC Microbiol. 2009, 9, 91.
McGillick, B. E.; Kumaran, D.; Vieni, C.; Swaminathan, S. Biochemistry 2016, 55, 1091.
Leesong, M.; Henderson, B. S.; Gillig, J. R.; Schwab, J. M.; Smith, J. L. Structure 1996, 4, 253.
Moynie, L.; Hope, A. G.; Finzel, K.; Schmidberger, J.; Leckie, S. M.; Schneider, G.; Burkart, M. D.; Smith, A. D.; Gray, D. W.; Naismith, J. H. J. Mol. Biol. 2016, 428, 108.
Kim, H. T.; Kim, S.; Na, B. K.; Chung, J.; Hwang, E.; Hwang, K. Y. Biochem. Biophys. Res. Commun. 2017, 493, 28.
Rafi, S.; Novichenok, P.; Kolappan, S.; Stratton, C. F.; Rawat, R.; Kisker, C.; Simmerling, C.; Tonge, P. J. J. Biol. Chem. 2006, 281, 39285.
Kim, K. H.; Ha, B. H.; Kim, S. J.; Hong, S. K.; Hwang, K. Y.; Kim, E. E. J. Mol. Biol. 2011, 406, 403.
Neckles, C.; Pschibul, A.; Lai, C. T.; Hirschbeck, M.; Kuper, J.; Davoodi, S.; Zou, J.; Liu, N.; Pan, P.; Shah, S.; Daryaee, F.; Bommineni, G. R.; Lai, C.; Simmerling, C.; Kisker, C.; Tonge, P. J. Biochemistry 2016, 55, 2992.
Li, H.; Zhang, X.; Bi, L.; He, J.; Jiang, T. PLoS One 2011, 6, e26743.
Kim, S. H.; Khan, R.; Choi, K.; Lee, S. W.; Rhee, S. FEBS J. 2020, 281, 4710.
Saito, J.; Yamada, M.; Watanabe, T.; Iida, M.; Kitagawa, H.; Takahata, S.; Ozawa, T.; Takeuchi, Y.; Ohsawa, F. Protein Sci. 2008, 17, 691.
Qiu, X.; Abdel-Meguid, S. S.; Janson, C. A.; Court, R. I.; Smyth, M. G.; Payne, D. J. Protein Sci. 1999, 8, 2529.
Miller, W. H.; Seefeld, M. A.; Newlander, K. A.; Uzinskas, I. N.; Burgess, W. J.; Heerding, D. A.; Yuan, C. C. K.; Head, M. S.; Payne, D. J.; Rittenhouse, S. F.; Moore, T. D.; Pearson, S. C.; Berry, V.; DeWolf, W. E.; Keller, P. M.; Polizzi, B. J.; Qiu, X.; Janson, C. A.; Huffman, W. F. J. Med. Chem. 2002, 45, 3246.
Seefeld, M. A.; Miller, W. H.; Newlander, K. A.; Burgess, W. J.; DeWolf, W. E.; Elkins, P. A.; Head, M. S.; Jakas, D. R.; Janson, C. A.; Keller, P. M.; Manley, P. J.; Moore, T. D.; Payne, D. J.; Pearson, S.; Polizzi, B. J.; Qiu, X.; Rittenhouse, S. F.; Uzinskas, I. N.; Wallis, N. G.; Huffman, W. F. J. Med. Chem. 2003, 46, 1627.
Heerding, D. A.; Chan, G.; DeWolf, W. E.; Fosberry, A. P.; Janson, C. A.; Jaworski, D. D.; McManus, E.; Miller, W. H.; Moore, T. D.; Payne, D. J.; Qiu, X.; Rittenhouse, S. F.; Slater-Radosti, C.; Smith, W.; Takata, D. T.; Vaidya, K. S.; Yuan, C. C. K.; Huffman, W. F. Bioorg. Med. Chem. Lett. 2001, 11, 2061.
Seefeld, M. A.; Miller, W. H.; Newlander, K. A.; Burgess, W. J.; Payne, D. J.; Rittenhouse, S. F.; Moore, T. D.; DeWolf, W. E.; Keller, P. M.; Qiu, X.; Janson, C. A.; Vaidya, K.; Fosberry, A. P.; Smyth, M. G.; Jaworski, D. D.; Slater-Radosti, C.; Huffman, W. F. Bioorg. Med. Chem. Lett. 2001, 11, 2241.
Ramnauth, J.; Surman, M. D.; Sampson, P. B.; Forrest, B.; Wilson, J.; Freeman, E.; Manning, D. D.; Martin, F.; Toro, A.; Domagala, M.; Awrey, D. E.; Bardouniotis, E.; Kaplan, N.; Berman, J.; Pauls, H. W. Bioorg. Med. Chem. Lett. 2009, 19, 5359.
Sampson, P. B.; Picard, C.; Handerson, S.; McGrath, T. E.; Domagala, M.; Leeson, A.; Romanov, V.; Awrey, D. E.; Thambipillai, D.; Bardouniotis, E.; Kaplan, N.; Berman, J. M.; Pauls, H. W. Bioorg. Med. Chem. Lett. 2009, 19, 5355.
Fage, C. D.; Lathouwers, T.; Vanmeert, M.; Gao, L. J.; Vrancken, K.; Lammens, E. M.; Weir, A. N. M.; Degroote, R.; Cuppens, H.; Kosol, S.; Simpson, T. J.; Crump, M. P.; Willis, C. L.; Herdewijn, P.; Lescrinier, E.; Lavigne, R.; Anne, J.; Masschelein, J. Angew. Chem. Int. Ed. 2020, 59, 10549.
Karlowsky, J. A.; Laing, N. M.; Baudry, T.; Kaplan, N.; Vaughan, D.; Hoban, D. J.; Zhanel, G. G. Antimicrob. Agents Chemother. 2007, 51, 1580.
Hafkin, B.; Kaplan, N.; Murphy, B. Antimicrob. Agents Chemother. 2015, 60, 1695.
Parker, E. N.; Drown, B. S.; Geddes, E. J.; Lee, H. Y.; Ismail, N.; Lau, G. W.; Hergenrother, P. J. Nat. Microbiol. 2020, 5, 67.
Ozawa, T.; Kitagawa, H.; Yamamoto, Y.; Takahata, S.; Iida, M.; Osaki, Y.; Yamada, K. Bioorg. Med. Chem. Lett. 2007, 15, 7325.
Jones, J. A.; Prior, A. M.; Marreddy, R. K. R.; Wahrmund, R. D.; Hurdle, J. G.; Sun, D.; Hevener, K. E. ACS Chem. Biol. 2019, 14, 1528.
Yu, Y. H.; Ma, J. R.; Wang, H. H. J. Microbiol. 2016, 4, 76 (in Chinese).
.
CCS Chemistry | 超分子活化底物为自由基促进高效选择性光催化氧化
. CCS Chemistry, 2025, 7(10.31635/ccschem.025.202405229): -.Kexin Dong , Chuqi Shen , Ruyu Yan , Yanping Liu , Chunqiang Zhuang , Shijie Li . Integration of Plasmonic Effect and S-Scheme Heterojunction into Ag/Ag3PO4/C3N5 Photocatalyst for Boosted Photocatalytic Levofloxacin Degradation. Acta Physico-Chimica Sinica, 2024, 40(10): 2310013-. doi: 10.3866/PKU.WHXB202310013
Hong CAI , Jiewen WU , Jingyun LI , Lixian CHEN , Siqi XIAO , Dan LI . Synthesis of a zinc-cobalt bimetallic adenine metal-organic framework for the recognition of sulfur-containing amino acids. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 114-122. doi: 10.11862/CJIC.20240382
Yikai Wang , Xiaolin Jiang , Haoming Song , Nan Wei , Yifan Wang , Xinjun Xu , Cuihong Li , Hao Lu , Yahui Liu , Zhishan Bo . 氰基修饰的苝二酰亚胺衍生物作为膜厚不敏感型阴极界面材料用于高效有机太阳能电池. Acta Physico-Chimica Sinica, 2025, 41(3): 2406007-. doi: 10.3866/PKU.WHXB202406007
Xingyang LI , Tianju LIU , Yang GAO , Dandan ZHANG , Yong ZHOU , Meng PAN . A superior methanol-to-propylene catalyst: Construction via synergistic regulation of pore structure and acidic property of high-silica ZSM-5 zeolite. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1279-1289. doi: 10.11862/CJIC.20240026
Hailian Tang , Siyuan Chen , Qiaoyun Liu , Guoyi Bai , Botao Qiao , Fei Liu . Stabilized Rh/hydroxyapatite Catalyst for Furfuryl Alcohol Hydrogenation: Application of Oxidative Strong Metal-Support Interactions in Reducing Conditions. Acta Physico-Chimica Sinica, 2025, 41(4): 100036-. doi: 10.3866/PKU.WHXB202408004
Jiapei Zou , Junyang Zhang , Xuming Wu , Cong Wei , Simin Fang , Yuxi Wang . A Comprehensive Experiment Based on Electrocatalytic Nitrate Reduction into Ammonia: Synthesis, Characterization, Performance Exploration, and Applicable Design of Copper-based Catalysts. University Chemistry, 2024, 39(6): 373-382. doi: 10.3866/PKU.DXHX202312081
Bing WEI , Jianfan ZHANG , Zhe CHEN . Research progress in fine tuning of bimetallic nanocatalysts for electrocatalytic carbon dioxide reduction. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 425-439. doi: 10.11862/CJIC.20240201
Lirui Shen , Kun Liu , Ying Yang , Dongwan Li , Wengui Chang . Synthesis and Application of Decanedioic Acid-N-Hydroxysuccinimide Ester: Exploration of Teaching Reform in Comprehensive Applied Chemistry Experiment. University Chemistry, 2024, 39(8): 212-220. doi: 10.3866/PKU.DXHX202312035
Ke Li , Chuang Liu , Jingping Li , Guohong Wang , Kai Wang . 钛酸铋/氮化碳无机有机复合S型异质结纯水光催化产过氧化氢. Acta Physico-Chimica Sinica, 2024, 40(11): 2403009-. doi: 10.3866/PKU.WHXB202403009
Jiaxuan Zuo , Kun Zhang , Jing Wang , Xifei Li . 锂离子电池Ni-Co-Mn基正极材料前驱体的形核调控及机制. Acta Physico-Chimica Sinica, 2025, 41(1): 2404042-. doi: 10.3866/PKU.WHXB202404042
Jiahui YU , Jixian DONG , Yutong ZHAO , Fuping ZHAO , Bo GE , Xipeng PU , Dafeng ZHANG . The morphology control and full-spectrum photodegradation tetracycline performance of microwave-hydrothermal synthesized BiVO4:Yb3+,Er3+ photocatalyst. Journal of Fuel Chemistry and Technology, 2025, 53(3): 348-359. doi: 10.1016/S1872-5813(24)60514-1
Yi DING , Peiyu LIAO , Jianhua JIA , Mingliang TONG . Structure and photoluminescence modulation of silver(Ⅰ)-tetra(pyridin-4-yl)ethene metal-organic frameworks by substituted benzoates. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 141-148. doi: 10.11862/CJIC.20240393
Yang Xia , Kangyan Zhang , Heng Yang , Lijuan Shi , Qun Yi . 构建双通道路径增强iCOF/Bi2O3 S型异质结在纯水体系中光催化合成H2O2性能. Acta Physico-Chimica Sinica, 2024, 40(11): 2407012-. doi: 10.3866/PKU.WHXB202407012
Minna Ma , Yujin Ouyang , Yuan Wu , Mingwei Yuan , Lijuan Yang . Green Synthesis of Medical Chemiluminescence Reagents by Photocatalytic Oxidation. University Chemistry, 2024, 39(5): 134-143. doi: 10.3866/PKU.DXHX202310093
Ran Yu , Chen Hu , Ruili Guo , Ruonan Liu , Lixing Xia , Cenyu Yang , Jianglan Shui . 杂多酸H3PW12O40高效催化MgH2储氢. Acta Physico-Chimica Sinica, 2025, 41(1): 2308032-. doi: 10.3866/PKU.WHXB202308032
Yuanyin Cui , Jinfeng Zhang , Hailiang Chu , Lixian Sun , Kai Dai . Rational Design of Bismuth Based Photocatalysts for Solar Energy Conversion. Acta Physico-Chimica Sinica, 2024, 40(12): 2405016-. doi: 10.3866/PKU.WHXB202405016
Dan Li , Hui Xin , Xiaofeng Yi . Comprehensive Experimental Design on Ni-based Catalyst for Biofuel Production. University Chemistry, 2024, 39(8): 204-211. doi: 10.3866/PKU.DXHX202312046
Juntao Yan , Liang Wei . 2D S-Scheme Heterojunction Photocatalyst. Acta Physico-Chimica Sinica, 2024, 40(10): 2312024-. doi: 10.3866/PKU.WHXB202312024
Peiran ZHAO , Yuqian LIU , Cheng HE , Chunying DUAN . A functionalized Eu3+ metal-organic framework for selective fluorescent detection of pyrene. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 713-724. doi: 10.11862/CJIC.20230355
(a) Overall crystal structures of apo-and holo-form ACP (from Helicobacter pylori, pdb codes: 5H9G and 5H9H), and Heptanoyl-ACP (from Escherichia coli, pdb code: 2FAD). (b) Chemical structure of the 4'-Phosphopantetheine (4'-Ppt) arm attached to ACP. (c) The primary sequence comparison of ACP α2 helix among bacteria. The conserved serine that can be modified by 4'-Ppt is marked with an asterisk.
(a) The schematic diagram of AcpS catalytic mechanism. (b) Overall crystal structure of ScAcpS-CoA complex. Key residues involved in CoA (purple) binding are shown in green/cyan sticks and labeled. (c) Overall crystal structure of BsAcpS-holo-ACP complex. (d) Superposition of CoA binding pocket among EcAcpS-holo-ACP (cyan), BsAcpS-holo-ACP (green) and ScAcpS-CoA (purple) complex structures. (e) The binding mode of the inhibitor Anthranilic-4 (purple) in the active pocket of BsAcpS. The residues involved in the binding are shown in green sticks and labeled, and the chemical structure of Anthranilic-4 is also shown.
(a) Schematic diagram of FabD catalytic mechanism. (b) Overall crystal structure of EcFabD in complex with malonyl-CoA (purple). Key residues involved in CoA (purple) binding are shown in green/cyan sticks and labeled.
(a) Schematic diagram of KAS family catalytic mechanisms. (b) Overall crystal structure of EcFabH. The conserved N-and C-terminal folding regions are labeled with black fonts, while the connection and insertion regions are labeled with grey fonts. (c) Superposition of EcFabB (green)-ACP(cyan) and EcFabF(blue)-ACP(yellow) complex structures. Black arrow shows conformational changes of key residues or loop structure. (d) The binding model of inhibitor TLM (purple) in the active pocket of EcFabB. The residues involved in the binding are shown in green sticks and labeled. (e) The binding model of inhibitor Cerulenin (purple) in the active pocket of BsFabF.
(a) Schematic diagram of FabG catalytic mechanism. (b) Overall crystal structure of EcFabG-NADH complex. The binding models of NADH (purple) in the active conformation (yellow) and inactive conformation (cyan) of EcFabG are shown. Key residues involved in the binding are shown in sticks and labeled. (c) Overall structure of VcFabG tetramer. The secondary elements on the dimer-dimer contact interface are labeled. (d) The binding model of allosteric inhibitor FG01 (purple) to PaFabG complex. Key residues involved in inhibitor binding from PaFabG A and B subunit are shown in green/cyan sticks and labeled.
(a) Schematic diagram of FabA/Z catalytic mechanisms. (b) Overall structure of PaFabA monomer. (c) Schematic diagram of the relationship between FabZ, FabA and bacteria-specific UFA key enzymes in Gram-negative (light green) and Gram-positive bacteria (cyan). (d) Overall crystal structures of EcFabA-ACP and HpFabZ-ACP complex; Key residues involved in the binding of ACP (purple) are shown in sticks and labeled. (e) Two binding models of inhibitor Pyridine-1 (purple) to HpFabZ. Key residues involved in the binding of ACP (purple) are shown in green sticks and labeled. (f) The covalent binding model of inhibitor 3-decenyl-N-acetylcysteamine (purple) to EcFabA.
(a) Schematic diagram of FabI catalytic mechanism. (b) Overall structure of EcFabI monomer. (c) Overall structure of EcFabI (green/blue/cyan/pink) in complex with ACP (yellow/red). (d) Superposition of proton transfer and NADH binding regions of EcFabI (green) and BsFabL (yellow). (e) Overall structure of XoFabV monomer. (f) Overall structure of TmFabK monomer; (g) The binding mode of inhibitor isoniazid-NAD (purple) with InhA. (h) The binding mode of inhibitor Triclosan (purple) with SaFabI. The ligand NADP+ are shown in yellow stick. (i) The binding mode of inhibitor PT173 (purple) with YpFabV. (j) The binding mode of inhibitor Phenylimidazole compound 1 (purple) with SpFabK. The ligand FMN is shown in yellow stick.