Citation: Zhou Jiashen, Zhang Lin, Zhang Liang. Advances on Mechanism and Drug Discovery of Type-Ⅱ Fatty Acid Biosynthesis Pathway[J]. Acta Chimica Sinica, ;2020, 78(12): 1383-1398. doi: 10.6023/A20070299 shu

Advances on Mechanism and Drug Discovery of Type-Ⅱ Fatty Acid Biosynthesis Pathway

Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Corresponding author: Zhang Liang, liangzhang2014@sjtu.edu.cn
Received Date: 8 July 2020
Available Online: 18 September 2020
Fund Project: Project supported by the Major Research Plan of the National Natural Science Foundation of China (Training Program) (No. 91853118) and Youth Program of National Natural Science Foundation of China (No. 21722802)the Major Research Plan of the National Natural Science Foundation of China(Training Program) 91853118Youth Program of National Natural Science Foundation of China 21722802

Figures(8)

Type-Ⅱ fatty acid biosynthesis pathway (FAS-Ⅱ) is the only essential biosynthesis pathway that producing saturated and unsaturated fatty acids for bacteria and plant cell assembly and cellular metabolism. It utilizes a series of individual enzymes encoded by discrete genes to stepwisely catalyze lipid chain growing carried by the substrate carrier protein-acyl carrier protein (ACP). Due to its indispensable biological role in bacteria growth, as well as the distinct biological regulation mechanisms from mammalian fatty acid biosynthesis (FAS-Ⅰ), the enzymes involved in FAS-Ⅱ have been considered as important anti-pathogenic drug targets for a long time. Hence, investigating the catalysis and dynamic regulation mechanisms of FAS-Ⅱ, developing novel anti-pathogenic drugs against the enzymes involved in FAS-Ⅱ is critical to the field. We here summarize the catalytic mechanism studies and inhibitor discovery work involved in FAS-Ⅱ so far, which may potentially facilitate further understanding of FAS-Ⅱ biological functions as well as antibacterial drug discovery for infectious diseases.
- type-Ⅱ fatty acid biosynthesis pathway (FAS-Ⅱ),
- acyl carrier protein (ACP),
- substrate recognition,
- catalysis regulation,
- inhibitor discovery
1. [1]
  Smith, S.; Witkowski, A.; Joshi, A. K. Prog. Lipid Res. 2003, 42, 289.
2. [2]
  White, S. W.; Zheng, J.; Zhang, Y. M.; Rock, C.O. Annu. Rev. Biochem. 2005, 74, 791.
3. [3]
  Cronan, J. E.; Thomas, J. Methods Enzymol. 2009, 459, 395.
4. [4]
  Anghel, S. I.; Wahli, W. Cell Res. 2007, 17, 486.
5. [5]
  Clay, H. B.; Parl, A. K.; Mitchell, S. L.; Singh, L.; Bell, L. N.; Murdock, D. G. PLoS One 2016, 11, e0151171.
6. [6]
  Nathan, C. J. Exp. Med. 2017, 214, 2175.
7. [7]
  Sukheja, P.; Kumar, P.; Mittal, N.; Li, S. G.; Singleton, E.; Russo, R.; Perryman, A. L.; Shrestha, R.; Awasthi, D.; Husain, S.; Soteropoulos, P.; Brukh, R.; Connell, N.; Freundlich, J. S.; Alland, D. mBio 2017, 8, e02022.
8. [8]
  Ballinger, E.; Mosior, J.; Hartman, T.; Burns-Huang, K.; Gold, B.; Morris, R.; Goullieux, L.; Blanc, I.; Vaubourgeix, J.; Lagrange, S.; Fraisse, L.; Sans, S.; Couturier, C.; Bacque, E.; Rhee, K.; Scarry, S. M.; Aube, J.; Yang, G.; Ouerfelli, O.; Schnappinger, D.; Ioerger, T. R.; Engelhart, C. A.; McConnell, J. A.; McAulay, K.; Fay, A.; Roubert, C.; Sacchettini, J.; Nathan, C. Science 2019, 363, 6426.
9. [9]
  Thorell, K.; Lehours, P.; Vale, F. F. Helicobacter 2017, 22 Suppl 1, e12409.
10. [10]
  Jimenez-Diaz, L.; Caballero, A.; Perez-Hernandez, N.; Segura, A. Microb. Biotechnol. 2017, 10, 103.
11. [11]
  Babu, M.; Greenblatt, J. F.; Emili, A.; Strynadka, N. C.; Reithmeier, R. A.; Moraes, T. F. Structure 2010, 18, 1450.
12. [12]
  Ohlrogge, J.; Savage, L.; Jaworski, J.; Voelker, T.; Postbeittenmiller, D. Arch. Biochem. Biophys. 1995, 317, 185.
13. [13]
  Chan, D. I.; Chu, B. C.; Lau, C. K.; Hunter, H. N.; Byers, D. M.; Vogel, H. J. J. Biol. Chem. 2010, 285, 30558.
14. [14]
  Dall'aglio, P.; Arthur, C. J.; Williams, C.; Vasilakis, K.; Maple, H. J.; Crosby, J.; Crump, M. P.; Hadfield, A. T. Biochemistry 2011, 50, 5704.
15. [15]
  Marcella, A. M.; Culbertson, S. J.; Shogren-Knaak, M. A.; Barb, A. W. J. Mol. Biol. 2017, 429, 3763.
16. [16]
  Keating, D. H.; Carey, M. R.; Cronan, J. E. J. Biol. Chem. 1995, 270, 22229.
17. [17]
  Bunkoczi, G.; Pasta, S.; Joshi, A.; Wu, X.; Kavanagh, K. L.; Smith, S.; Oppermann, U. Chem. Biol. 2007, 14, 1243.
18. [18]
  Joseph-McCarthy, D.; Parris, K.; Huang, A.; Failli, A.; Quagliato, D.; Dushin, E. G.; Novikova, E.; Severina, E.; Tuckman, M.; Petersen, P. J.; Dean, C.; Fritz, C. C.; Meshulam, T.; DeCenzo, M.; Dick, L.; McFadyen, I. J.; Somers, W. S.; Lovering, F.; Gilbert, A. M. J. Med. Chem. 2005, 48, 7960.
19. [19]
  Chu, M.; Mierzwa, R.; Xu, L.; Yang, S. W.; He, L.; Patel, M.; Stafford, J.; Macinga, D.; Black, T.; Chan, T. M.; Gullo, V. Bioorg. Med. Chem. Lett. 2003, 13, 3827.
20. [20]
  Ruch, F. E.; Vagelos, P. R. J. Biol. Chem. 1973, 248, 8095.
21. [21]
  Hong, S. K.; Kim, K. H.; Park, J. K.; Jeong, K. W.; Kim, Y.; Kim, E. E. FEBS Lett. 2010, 584, 1240.
22. [22]
  Lee, W. C.; Park, J.; Balasubramanian, P. K.; Kim, Y. Biochem. Biophys. Res. Commun. 2018, 505, 208.
23. [23]
  Li, Z.; Huang, Y.; Ge, J.; Fan, H.; Zhou, X.; Li, S.; Bartlam, M.; Wang, H.; Rao, Z. J. Mol. Biol. 2007, 371, 1075.
24. [24]
  Keatinge-Clay, A. T.; Shelat, A. A.; Savage, D. F.; Tsai, S.-C.; Miercke, L. J. W.; O'Connell, J. D.; Khosla, C.; Stroud, R. M. Structure 2003, 11, 147.
25. [25]
  Liu, W.; Han, C.; Hu, L.; Chen, K.; Shen, X.; Jiang, H. FEBS Lett. 2006, 580, 697.
26. [26]
  Kong, Y. H.; Zhang, L.; Yang, Z. Y.; Han, C.; Hu, L. H.; Jiang, H. L.; Shen, X. Acta Pharmacol. Sin. 2008, 29, 870.
27. [27]
  Kumar, V.; Sharma, A.; Pratap, S.; Kumar, P. Biochimie 2018, 149, 18.
28. [28]
  Kumar, V.; Sharma, A.; Pratap, S.; Kumar, P. BBA-Proteins Proteom 2018, 1866, 1131.
29. [29]
  Li, Y.; Florova, G.; Reynolds, K. A. J. Bacteriol. 2005, 187, 3795.
30. [30]
  Han, L.; Lobo, S.; Reynolds, K. A. J. Bacteriol. 1998, 180, 4481.
31. [31]
  Tsay, J. T.; Oh, W.; Larson, T. J.; Jackowski, S.; Rock, C. O. J. Biol. Chem. 1992, 267, 6807.
32. [32]
  Gajiwala, K. S.; Margosiak, S.; Lu, J.; Cortez, J.; Su, Y.; Nie, Z.; Appelt, K. FEBS Lett. 2009, 583, 2939.
33. [33]
  Yuan, Y.; Sachdeva, M.; Leeds, J. A.; Meredith, T. C. J. Bacteriol. 2012, 194, 5171.
34. [34]
  Milligan, J. C.; Lee, D. J.; Jackson, D. R.; Schaub, A. J.; Beld, J.; Barajas, J. F.; Hale, J. J.; Luo, R.; Burkart, M. D.; Tsai, S. C. Nat. Chem. Biol. 2019, 15, 669.
35. [35]
  Mindrebo, J. T.; Patel, A.; Kim, W. E.; Davis, T. D.; Chen, A.; Bartholow, T. G.; La Clair, J. J.; McCammon, J. A.; Noel, J. P.; Burkart, M. D. Nat. Commun. 2020, 11, 1727.
36. [36]
  Nanson, J. D.; Himiari, Z.; Swarbrick, C. M.; Forwood, J. K. Sci. Rep. 2015, 5, 14797.
37. [37]
  Price, A. C.; Choi, K. H.; Heath, R. J.; Li, Z.; White, S. W.; Rock, C. O. J. Biol. Chem. 2001, 276, 6551.
38. [38]
  Wang, J.; Kodali, S.; Lee, S. H.; Galgoci, A.; Painter, R.; Dorso, K.; Racine, F.; Motyl, M.; Hernandez, L.; Tinney, E.; Colletti, S. L.; Herath, K.; Cummings, R.; Salazar, O.; González, I.; Basilio, A.; Vicente, F.; Genilloud, O.; Pelaez, F.; Jayasuriya, H.; Young, K.; Cully, D. F.; Singh, S. B. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 7612.
39. [39]
  Daines, R. A.; Pendrak, I.; Sham, K.; Van Aller, G. S.; Konstantinidis, A. K.; Lonsdale, J. T.; Janson, C. A.; Qiu, X.; Brandt, M.; Khandekar, S. S.; Silverman, C.; Head, M. S. J. Med. Chem. 2003, 46, 5.
40. [40]
  McKinney, D. C.; Eyermann, C. J.; Gu, R. F.; Hu, J.; Kazmirski, S. L.; Lahiri, S. D.; McKenzie, A. R.; Shapiro, A. B.; Breault, G. ACS Infect. Dis. 2016, 2, 456.
41. [41]
  Wang, J.; Soisson, S. M.; Young, K.; Shoop, W.; Kodali, S.; Galgoci, A.; Painter, R.; Parthasarathy, G.; Tang, Y. S.; Cummings, R.; Ha, S.; Dorso, K.; Motyl, M.; Jayasuriya, H.; Ondeyka, J.; Herath, K.; Zhang, C.; Hernandez, L.; Allocco, J.; Basilio, A.; Tormo, J. R.; Genilloud, O.; Vicente, F.; Pelaez, F.; Colwell, L.; Lee, S. H.; Michael, B.; Felcetto, T.; Gill, C.; Silver, L. L.; Hermes, J. D.; Bartizal, K.; Barrett, J.; Schmatz, D.; Becker, J. W.; Cully, D.; Singh, S. B. Nature 2006, 441, 358.
42. [42]
  Zheng, Z.; Parsons, J. B.; Tangallapally, R.; Zhang, W.; Rock, C. O.; Lee, R. E. Bioorg. Med. Chem. Lett. 2014, 24, 2585.
43. [43]
  Kallberg, Y.; Oppermann, U.; Jornvall, H.; Persson, B. Eur. J. Biochem. 2002, 269, 4409.
44. [44]
  Hou, J.; Zheng, H.; Chruszcz, M.; Zimmerman, M. D.; Shumilin, I. A.; Osinski, T.; Demas, M.; Grimshaw, S.; Minor, W. J. Bacteriol. 2016, 198, 463.
45. [45]
  Price, A. C.; Zhang, Y.-M.; Rock, C. O.; White, S. W. Biochemistry 2001, 40, 12772.
46. [46]
  Silva, R. G.; Rosado, L. A.; Santos, D. S.; Basso, L. A. Arch. Biochem. Biophys. 2008, 471, 1.
47. [47]
  Price, A. C.; Zhang, Y. M.; Rock, C. O.; White, S. W. Structure 2004, 12, 417.
48. [48]
  Cohen-Gonsaud, M.; Ducasse-Cabanot, S.; Quemard, A.; Labesse, G. Proteins 2005, 60, 392.
49. [49]
  Cukier, C. D.; Hope, A. G.; Elamin, A. A.; Moynie, L.; Schnell, R.; Schach, S.; Kneuper, H.; Singh, M.; Naismith, J. H.; Lindqvist, Y.; Gray, D. W.; Schneider, G. ACS Chem. Biol. 2013, 8, 2518.
50. [50]
  Lai, C. Y.; Cronan, J. E. J. Bacteriol. 2004, 186, 1869.
51. [51]
  Sohn, M.-J.; Zheng, C.-J.; Kim, W.-G. J. Antibiot. 2008, 61, 687.
52. [52]
  Wickramasinghe, S. R.; Inglis, K. A.; Urch, J. E.; Muller, S.; van Aalten, D. M.; Fairlamb, A. H. Biochem. J. 2006, 393, 447.
53. [53]
  Tasdemir, D.; Lack, G.; Brun, R.; Rüedi, P.; Scapozza, L.; Perozzo, R. J. Med. Chem. 2006, 49, 3345.
54. [54]
  Zhang, F.; Luo, S. Y.; Ye, Y. B.; Zhao, W. H.; Sun, X. G.; Wang, Z. Q.; Li, R.; Sun, Y. H.; Tian, W. X.; Zhang, Y. X. Biotechnol. Appl. Biochem. 2008, 51, 73.
55. [55]
  Zeng, D.; Zhao, J.; Chung, H. S.; Guan, Z.; Raetz, C. R.; Zhou, P. J. Biol. Chem. 2013, 288, 5475.
56. [56]
  Swarnamukhi, P. L.; Sharma, S. K.; Bajaj, P.; Surolia, N.; Surolia, A.; Suguna, K. FEBS Lett. 2006, 580, 2653.
57. [57]
  Zhang, L.; Xiao, J.; Xu, J.; Fu, T.; Cao, Z.; Zhu, L.; Chen, H. Z.; Shen, X.; Jiang, H.; Zhang, L. Cell Res. 2016, 26, 1330.
58. [58]
  Shen, S.; Hang, X.; Zhuang, J.; Zhang, L.; Bi, H.; Zhang, L. Int. J. Biol. Macromol. 2019, 128, 5.
59. [59]
  Dodge, G. J.; Patel, A.; Jaremko, K. L.; McCammon, J. A.; Smith, J. L.; Burkart, M. D. Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 6775.
60. [60]
  Moynie, L.; Leckie, S. M.; McMahon, S. A.; Duthie, F. G.; Koehnke, A.; Taylor, J. W.; Alphey, M. S.; Brenk, R.; Smith, A. D.; Naismith, J. H. J. Mol. Biol. 2013, 425, 365.
61. [61]
  Heath, R. J.; Rock, C. O. J. Biol. Chem. 1996, 271, 27795.
62. [62]
  Nguyen, C.; Haushalter, R. W.; Lee, D. J.; Markwick, P. R.; Bruegger, J.; Caldara-Festin, G.; Finzel, K.; Jackson, D. R.; Ishikawa, F.; O'Dowd, B.; McCammon, J. A.; Opella, S. J.; Tsai, S. C.; Burkart, M. D. Nature 2014, 505, 427.
63. [63]
  Bi, H.; Zhu, L.; Jia, J.; Zeng, L.; Cronan, J. E. Cell Chem. Biol. 2016, 23, 1480.
64. [64]
  Wang, H.; Cronan, J. E. J. Biol. Chem. 2004, 279, 34489.
65. [65]
  Bi, H.; Wang, H.; Cronan, J. E. Chem. Biol. 2013, 20, 1157.
66. [66]
  Marrakchi, H.; Choi, K. H.; Rock, C. O. J. Biol. Chem. 2002, 277, 44809.
67. [67]
  Aguilar, P. S.; Cronan, J. E.; de Mendoza, D. J. Bacteriol. 1998, 180, 2194.
68. [68]
  Sharma, S. K.; Kapoor, M.; Ramya, T. N.; Kumar, S.; Kumar, G.; Modak, R.; Sharma, S.; Surolia, N.; Surolia, A. J. Biol. Chem. 2003, 278, 45661.
69. [69]
  Zhang, L.; Liu, W.; Hu, T.; Du, L.; Luo, C.; Chen, K.; Shen, X.; Jiang, H. J. Biol. Chem. 2008, 283, 5370.
70. [70]
  He, L.; Zhang, L.; Liu, X.; Li, X.; Zheng, M.; Li, H.; Yu, K.; Chen, K.; Shen, X.; Jiang, H.; Liu, H. J. Med. Chem. 2009, 52, 2465.
71. [71]
  Zhang, L.; Kong, Y.; Wu, D.; Zhang, H.; Wu, J.; Chen, J.; Ding, J.; Hu, L.; Jiang, H.; Shen, X. Protein Sci. 2008, 17, 1971.
72. [72]
  Chen, J.; Zhang, L.; Zhang, Y.; Zhang, H.; Du, J.; Ding, J.; Guo, Y.; Jiang, H.; Shen, X. BMC Microbiol. 2009, 9, 91.
73. [73]
  McGillick, B. E.; Kumaran, D.; Vieni, C.; Swaminathan, S. Biochemistry 2016, 55, 1091.
74. [74]
  Leesong, M.; Henderson, B. S.; Gillig, J. R.; Schwab, J. M.; Smith, J. L. Structure 1996, 4, 253.
75. [75]
  Moynie, L.; Hope, A. G.; Finzel, K.; Schmidberger, J.; Leckie, S. M.; Schneider, G.; Burkart, M. D.; Smith, A. D.; Gray, D. W.; Naismith, J. H. J. Mol. Biol. 2016, 428, 108.
76. [76]
  Kim, H. T.; Kim, S.; Na, B. K.; Chung, J.; Hwang, E.; Hwang, K. Y. Biochem. Biophys. Res. Commun. 2017, 493, 28.
77. [77]
  Rafi, S.; Novichenok, P.; Kolappan, S.; Stratton, C. F.; Rawat, R.; Kisker, C.; Simmerling, C.; Tonge, P. J. J. Biol. Chem. 2006, 281, 39285.
78. [78]
  Kim, K. H.; Ha, B. H.; Kim, S. J.; Hong, S. K.; Hwang, K. Y.; Kim, E. E. J. Mol. Biol. 2011, 406, 403.
79. [79]
  Neckles, C.; Pschibul, A.; Lai, C. T.; Hirschbeck, M.; Kuper, J.; Davoodi, S.; Zou, J.; Liu, N.; Pan, P.; Shah, S.; Daryaee, F.; Bommineni, G. R.; Lai, C.; Simmerling, C.; Kisker, C.; Tonge, P. J. Biochemistry 2016, 55, 2992.
80. [80]
  Li, H.; Zhang, X.; Bi, L.; He, J.; Jiang, T. PLoS One 2011, 6, e26743.
81. [81]
  Kim, S. H.; Khan, R.; Choi, K.; Lee, S. W.; Rhee, S. FEBS J. 2020, 281, 4710.
82. [82]
  Saito, J.; Yamada, M.; Watanabe, T.; Iida, M.; Kitagawa, H.; Takahata, S.; Ozawa, T.; Takeuchi, Y.; Ohsawa, F. Protein Sci. 2008, 17, 691.
83. [83]
  Qiu, X.; Abdel-Meguid, S. S.; Janson, C. A.; Court, R. I.; Smyth, M. G.; Payne, D. J. Protein Sci. 1999, 8, 2529.
84. [84]
  Miller, W. H.; Seefeld, M. A.; Newlander, K. A.; Uzinskas, I. N.; Burgess, W. J.; Heerding, D. A.; Yuan, C. C. K.; Head, M. S.; Payne, D. J.; Rittenhouse, S. F.; Moore, T. D.; Pearson, S. C.; Berry, V.; DeWolf, W. E.; Keller, P. M.; Polizzi, B. J.; Qiu, X.; Janson, C. A.; Huffman, W. F. J. Med. Chem. 2002, 45, 3246.
85. [85]
  Seefeld, M. A.; Miller, W. H.; Newlander, K. A.; Burgess, W. J.; DeWolf, W. E.; Elkins, P. A.; Head, M. S.; Jakas, D. R.; Janson, C. A.; Keller, P. M.; Manley, P. J.; Moore, T. D.; Payne, D. J.; Pearson, S.; Polizzi, B. J.; Qiu, X.; Rittenhouse, S. F.; Uzinskas, I. N.; Wallis, N. G.; Huffman, W. F. J. Med. Chem. 2003, 46, 1627.
86. [86]
  Heerding, D. A.; Chan, G.; DeWolf, W. E.; Fosberry, A. P.; Janson, C. A.; Jaworski, D. D.; McManus, E.; Miller, W. H.; Moore, T. D.; Payne, D. J.; Qiu, X.; Rittenhouse, S. F.; Slater-Radosti, C.; Smith, W.; Takata, D. T.; Vaidya, K. S.; Yuan, C. C. K.; Huffman, W. F. Bioorg. Med. Chem. Lett. 2001, 11, 2061.
87. [87]
  Seefeld, M. A.; Miller, W. H.; Newlander, K. A.; Burgess, W. J.; Payne, D. J.; Rittenhouse, S. F.; Moore, T. D.; DeWolf, W. E.; Keller, P. M.; Qiu, X.; Janson, C. A.; Vaidya, K.; Fosberry, A. P.; Smyth, M. G.; Jaworski, D. D.; Slater-Radosti, C.; Huffman, W. F. Bioorg. Med. Chem. Lett. 2001, 11, 2241.
88. [88]
  Ramnauth, J.; Surman, M. D.; Sampson, P. B.; Forrest, B.; Wilson, J.; Freeman, E.; Manning, D. D.; Martin, F.; Toro, A.; Domagala, M.; Awrey, D. E.; Bardouniotis, E.; Kaplan, N.; Berman, J.; Pauls, H. W. Bioorg. Med. Chem. Lett. 2009, 19, 5359.
89. [89]
  Sampson, P. B.; Picard, C.; Handerson, S.; McGrath, T. E.; Domagala, M.; Leeson, A.; Romanov, V.; Awrey, D. E.; Thambipillai, D.; Bardouniotis, E.; Kaplan, N.; Berman, J. M.; Pauls, H. W. Bioorg. Med. Chem. Lett. 2009, 19, 5355.
90. [90]
  Fage, C. D.; Lathouwers, T.; Vanmeert, M.; Gao, L. J.; Vrancken, K.; Lammens, E. M.; Weir, A. N. M.; Degroote, R.; Cuppens, H.; Kosol, S.; Simpson, T. J.; Crump, M. P.; Willis, C. L.; Herdewijn, P.; Lescrinier, E.; Lavigne, R.; Anne, J.; Masschelein, J. Angew. Chem. Int. Ed. 2020, 59, 10549.
91. [91]
  Karlowsky, J. A.; Laing, N. M.; Baudry, T.; Kaplan, N.; Vaughan, D.; Hoban, D. J.; Zhanel, G. G. Antimicrob. Agents Chemother. 2007, 51, 1580.
92. [92]
  Hafkin, B.; Kaplan, N.; Murphy, B. Antimicrob. Agents Chemother. 2015, 60, 1695.
93. [93]
  Parker, E. N.; Drown, B. S.; Geddes, E. J.; Lee, H. Y.; Ismail, N.; Lau, G. W.; Hergenrother, P. J. Nat. Microbiol. 2020, 5, 67.
94. [94]
  Ozawa, T.; Kitagawa, H.; Yamamoto, Y.; Takahata, S.; Iida, M.; Osaki, Y.; Yamada, K. Bioorg. Med. Chem. Lett. 2007, 15, 7325.
95. [95]
  Jones, J. A.; Prior, A. M.; Marreddy, R. K. R.; Wahrmund, R. D.; Hurdle, J. G.; Sun, D.; Hevener, K. E. ACS Chem. Biol. 2019, 14, 1528.
96. [96]
  Yu, Y. H.; Ma, J. R.; Wang, H. H. J. Microbiol. 2016, 4, 76 (in Chinese).
1. [1]
  Kexin Dong , Chuqi Shen , Ruyu Yan , Yanping Liu , Chunqiang Zhuang , Shijie Li . Integration of Plasmonic Effect and S-Scheme Heterojunction into Ag/Ag₃PO₄/C₃N₅ Photocatalyst for Boosted Photocatalytic Levofloxacin Degradation. Acta Physico-Chimica Sinica, 2024, 40(10): 2310013-. doi: 10.3866/PKU.WHXB202310013
2. [2]
  Xingyang LI , Tianju LIU , Yang GAO , Dandan ZHANG , Yong ZHOU , Meng PAN . A superior methanol-to-propylene catalyst: Construction via synergistic regulation of pore structure and acidic property of high-silica ZSM-5 zeolite. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1279-1289. doi: 10.11862/CJIC.20240026
3. [3]
  Lirui Shen , Kun Liu , Ying Yang , Dongwan Li , Wengui Chang . Synthesis and Application of Decanedioic Acid-N-Hydroxysuccinimide Ester: Exploration of Teaching Reform in Comprehensive Applied Chemistry Experiment. University Chemistry, 2024, 39(8): 212-220. doi: 10.3866/PKU.DXHX202312035
4. [4]
  Jiapei Zou , Junyang Zhang , Xuming Wu , Cong Wei , Simin Fang , Yuxi Wang . A Comprehensive Experiment Based on Electrocatalytic Nitrate Reduction into Ammonia: Synthesis, Characterization, Performance Exploration, and Applicable Design of Copper-based Catalysts. University Chemistry, 2024, 39(6): 373-382. doi: 10.3866/PKU.DXHX202312081
5. [5]
  Ke Li , Chuang Liu , Jingping Li , Guohong Wang , Kai Wang . 钛酸铋/氮化碳无机有机复合S型异质结纯水光催化产过氧化氢. Acta Physico-Chimica Sinica, 2024, 40(11): 2403009-. doi: 10.3866/PKU.WHXB202403009
6. [6]
  Yang Xia , Kangyan Zhang , Heng Yang , Lijuan Shi , Qun Yi . 构建双通道路径增强iCOF/Bi₂O₃ S型异质结在纯水体系中光催化合成H₂O₂性能. Acta Physico-Chimica Sinica, 2024, 40(11): 2407012-. doi: 10.3866/PKU.WHXB202407012
7. [7]
  Minna Ma , Yujin Ouyang , Yuan Wu , Mingwei Yuan , Lijuan Yang . Green Synthesis of Medical Chemiluminescence Reagents by Photocatalytic Oxidation. University Chemistry, 2024, 39(5): 134-143. doi: 10.3866/PKU.DXHX202310093
8. [8]
  Yuanyin Cui , Jinfeng Zhang , Hailiang Chu , Lixian Sun , Kai Dai . Rational Design of Bismuth Based Photocatalysts for Solar Energy Conversion. Acta Physico-Chimica Sinica, 2024, 40(12): 2405016-. doi: 10.3866/PKU.WHXB202405016
9. [9]
  Dan Li , Hui Xin , Xiaofeng Yi . Comprehensive Experimental Design on Ni-based Catalyst for Biofuel Production. University Chemistry, 2024, 39(8): 204-211. doi: 10.3866/PKU.DXHX202312046
10. [10]
  Peiran ZHAO , Yuqian LIU , Cheng HE , Chunying DUAN . A functionalized Eu³⁺ metal-organic framework for selective fluorescent detection of pyrene. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 713-724. doi: 10.11862/CJIC.20230355
11. [11]
  Juntao Yan , Liang Wei . 2D S-Scheme Heterojunction Photocatalyst. Acta Physico-Chimica Sinica, 2024, 40(10): 2312024-. doi: 10.3866/PKU.WHXB202312024
12. [12]
  Wen YANG , Didi WANG , Ziyi HUANG , Yaping ZHOU , Yanyan FENG . La promoted hydrotalcite derived Ni-based catalysts: In situ preparation and CO₂ methanation performance. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 561-570. doi: 10.11862/CJIC.20230276
13. [13]
  Zhiquan Zhang , Baker Rhimi , Zheyang Liu , Min Zhou , Guowei Deng , Wei Wei , Liang Mao , Huaming Li , Zhifeng Jiang . Insights into the Development of Copper-based Photocatalysts for CO₂ Conversion. Acta Physico-Chimica Sinica, 2024, 40(12): 2406029-. doi: 10.3866/PKU.WHXB202406029
14. [14]
  Qingying Gao , Tao Luo , Jianyuan Su , Chaofan Yu , Jiazhu Li , Bingfei Yan , Wenzuo Li , Zhen Zhang , Yi Liu . Refinement and Expansion of the Classic Cinnamic Acid Synthesis Experiment. University Chemistry, 2024, 39(5): 243-250. doi: 10.3866/PKU.DXHX202311074
15. [15]
  Yi YANG , Shuang WANG , Wendan WANG , Limiao CHEN . Photocatalytic CO₂ reduction performance of Z-scheme Ag-Cu₂O/BiVO₄ photocatalyst. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 895-906. doi: 10.11862/CJIC.20230434
16. [16]
  Jingjie Tang , Luying Xie , Jiayu Liu , Shangyu Shi , Xinyu Sun , Jiayang Lin , Qikun Yang , Chuan'ang Yu , Zecheng Wang , Yingying Wang , Zengyang Xie . Efficient Rapid Synthesis and Antibacterial Activities of Tosylhydrazones: A Recommended Innovative Chemistry Experiment for Undergraduate Medical University. University Chemistry, 2024, 39(3): 316-326. doi: 10.3866/PKU.DXHX202309091
17. [17]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
18. [18]
  Haiyu Nie , Chenhui Zhang , Fengpei Du . Ideological and Political Design for the Preparation, Characterization and Particle Size Control Experiment of Nanoemulsion. University Chemistry, 2024, 39(2): 41-46. doi: 10.3866/PKU.DXHX202306055
19. [19]
  Zhiwen HU , Weixia DONG , Qifu BAO , Ping LI . Low-temperature synthesis of tetragonal BaTiO₃ for piezocatalysis. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 857-866. doi: 10.11862/CJIC.20230462
20. [20]
  Guimin ZHANG , Wenjuan MA , Wenqiang DING , Zhengyi FU . Synthesis and catalytic properties of hollow AgPd bimetallic nanospheres. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 963-971. doi: 10.11862/CJIC.20230293

Get Citation

PDF

XML

Metrics

PDF Downloads(143)
Abstract views(6407)
HTML views(1721)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142