Citation: Ma Qiulin, Feng Nan, Ju Huangxian. Advances in Analytical Methodology of Prostate Cancer Markers[J]. Acta Chimica Sinica, ;2020, 78(11): 1213-1222. doi: 10.6023/A20060259 shu

Advances in Analytical Methodology of Prostate Cancer Markers

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Corresponding author: Ju Huangxian, hxju@nju.edu.cn
Received Date: 22 June 2020
Available Online: 24 August 2020
Fund Project: the National Natural Science Foundation of China 21635005the National Natural Science Foundation of China 21890741the National Natural Science Foundation of China 21827812Project supported by the National Natural Science Foundation of China (Nos. 21635005, 21827812, 21890741)

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The detection of tumor markers plays an important role in the screening, early diagnosis and treatment of high-risk cancer patients. Prostatic cancer is one of the most common malignancies of the male genitourinary system, and has an increasing trend in recent years. Its morbidity is generally influenced by region and ethnicity. The common clinical markers of prostate cancer include prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA), alpha-formyl kievase A mesozyme (AMACR, P504S), prostate-acid phosphatase (PAP), and calcium phosphatidyl binding protein 3 (ANXA3). Most of these markers are composed of proteins or enzymes, which are produced by normal or cancerous prostate cells. Of these, prostate-specific antigen (PSA) and prostate-acid phosphatase (PAP) are considered to be the most meaningful markers of the prostatic cancer. Detection of PSA is widely used in the early detection and monitoring of prostate cancer patients, while analysis of PAP is often used to detect advanced prostate cancer metastases and evaluate the therapeutic effect. Therefore, the analysis of PSA and PAP in the human serum is of great significance for the monitoring of disease status in clinical diagnosis and treatment. In this review the recent advances in the methodological study for detection of prostate cancer markers are reviewed along with the description of their structures and biological functions. The detection technologies of prostate-specific antigen and prostate acid phosphatase are emphatically introduced, which mainly contain colorimetric techniques, electrochemical methods, fluorescence methods and surface resonance plasmon techniques. On the basis of summarizing the research progress in this field in recent decades, the future development of prostate cancer marker analysis is prospected. This review is expected to provide a useful guidance for the study of prostate cancer markers.
- cancer markers,
- prostate cancer,
- prostate-specific antigen,
- prostatic acid phosphatase,
- detection methododology
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