Citation: Ma Qiulin, Feng Nan, Ju Huangxian. Advances in Analytical Methodology of Prostate Cancer Markers[J]. Acta Chimica Sinica, ;2020, 78(11): 1213-1222. doi: 10.6023/A20060259 shu

Advances in Analytical Methodology of Prostate Cancer Markers

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Corresponding author: Ju Huangxian, hxju@nju.edu.cn
Received Date: 22 June 2020
Available Online: 24 August 2020
Fund Project: the National Natural Science Foundation of China 21635005the National Natural Science Foundation of China 21890741the National Natural Science Foundation of China 21827812Project supported by the National Natural Science Foundation of China (Nos. 21635005, 21827812, 21890741)

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The detection of tumor markers plays an important role in the screening, early diagnosis and treatment of high-risk cancer patients. Prostatic cancer is one of the most common malignancies of the male genitourinary system, and has an increasing trend in recent years. Its morbidity is generally influenced by region and ethnicity. The common clinical markers of prostate cancer include prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA), alpha-formyl kievase A mesozyme (AMACR, P504S), prostate-acid phosphatase (PAP), and calcium phosphatidyl binding protein 3 (ANXA3). Most of these markers are composed of proteins or enzymes, which are produced by normal or cancerous prostate cells. Of these, prostate-specific antigen (PSA) and prostate-acid phosphatase (PAP) are considered to be the most meaningful markers of the prostatic cancer. Detection of PSA is widely used in the early detection and monitoring of prostate cancer patients, while analysis of PAP is often used to detect advanced prostate cancer metastases and evaluate the therapeutic effect. Therefore, the analysis of PSA and PAP in the human serum is of great significance for the monitoring of disease status in clinical diagnosis and treatment. In this review the recent advances in the methodological study for detection of prostate cancer markers are reviewed along with the description of their structures and biological functions. The detection technologies of prostate-specific antigen and prostate acid phosphatase are emphatically introduced, which mainly contain colorimetric techniques, electrochemical methods, fluorescence methods and surface resonance plasmon techniques. On the basis of summarizing the research progress in this field in recent decades, the future development of prostate cancer marker analysis is prospected. This review is expected to provide a useful guidance for the study of prostate cancer markers.
- cancer markers,
- prostate cancer,
- prostate-specific antigen,
- prostatic acid phosphatase,
- detection methododology
1. [1]
  Han, S.-J.; Zhang, S.-W.; Chen, W.-Q.; Li, C.-L. Chin. J. Clin. Oncol. 2013, 18, 330(in Chinese).
2. [2]
  Wu, Q.-J.; Xu, J.-F. Shi, R. J. Shanghai Jiaotong Univ., Med. Sci. 2011, 31, 672(in Chinese).
3. [3]
  Cuzick, J.; Thorat, M. Lancet Oncol. 2014, 15, 484. doi: 10.1016/S1470-2045(14)70056-7
4. [4]
  Xiang, D.-C.; Liu, H.; Meng, Q.-H.; Lan, M.-B.; Wei, G. Acta Chim. Sinica 2013, 71, 1435(in Chinese).
5. [5]
  Zhang, Y.; Zhang, L.-Y.; Liu, L.-M.; Wang, T.; Meng, Y.-Q.; Li, N.; Li, E.-D.; Wang, Z.-J.; Liu, X.-J.; Zheng, J.-X.; Shan, L.-H.; Liu, H.-M.; Zhang, Q.-R. Chin. J. Org. Chem. 2020, 40, 1731. doi: 10.6023/cjoc202001034
6. [6]
  Liu, X.; Zhao, J.; Feng, C.-G. Acta Chim. Sinica 2006, 64, 1988(in Chinese).
7. [7]
  He, Q.; Zhang, G.-H. Prog. Oncol. 2017, 15, 7(in Chinese).
8. [8]
9. [9]
  Yan, H.-Y.; Xing, J.-C.; Zhang, K.-Y.; Wang, T.; Bai, P.-D. J. Clin. Urology (China) 2020, 35, 242(in Chinese).
10. [10]
  Ghorbania, F.; Abbaszadehb, H.; Dolatabadic, J. E. N.; Aghebati-Malekid, L.; Yousefi, M. Biosens. Bioelectron. 2019, 142, 111484. doi: 10.1016/j.bios.2019.111484
11. [11]
  Vickers, A.; Cronin, A.; Roobol M. Clin. Cancer Res. 2010, 16, 4374. doi: 10.1158/1078-0432.CCR-10-1328
12. [12]
  Lilja, H.; Oldbring, J.; Rannevik, G. J. Clin. Invest. 1987, 80, 281. doi: 10.1172/JCI113070
13. [13]
  Oesterling, J. J. Urol. 1991, 145, 907. doi: 10.1016/S0022-5347(17)38491-4
14. [14]
  Lilja, H.; Ulmert, D.; Vickers, A. J. Nat. Rev. 2008, 8, 268. doi: 10.1038/nrc2351
15. [15]
  Stenman, U. H.; Leinonen, J.; Zhang, W. M. Semin. Cancer Biol. 1999, 19, 83.
16. [16]
  Frydeberg, M.; Stricker, P. D.; Kaye, K. W. Lancet 2005, 349, 1681.
17. [17]
  Salman, J. W.; Schoots, I.; Carlsson, S. V. Adv. Exp. Med Biol. 2015, 867, 93.
18. [18]
  Desmée, S.; Mentré, F.; Veyrat-Follet, C. AAPS J. 2015, 17, 691. doi: 10.1208/s12248-015-9745-5
19. [19]
  Chen, R.; Huang, Y. R.; Cai, X. B. PLoS One 2015, 10, 130308.
20. [20]
  Vickers, A. J.; Cronin, A. M.; Aus, G. Cancer 2010, 116, 2612.
21. [21]
  Denmeade, S. R.; Lou, W.; Lövgren, J.; Isaacs, J. T. Cancer Res. 1997, 57, 4924.
22. [22]
  Liu, D.; Huang, X.; Wang, F.; Ma, Y.; Niu, G.; Hight-Walker, A. R.; Chen, X. ACS Nano 2013, 7, 5568. doi: 10.1021/nn401837q
23. [23]
  Uludag, Y.; Tothill, I. E. Anal. Chem. 2012, 84, 5898. doi: 10.1021/ac300278p
24. [24]
  Triroj, N.; Jaroenapibal, P.; Beresford, R. Biosens. Bioelectron. 2011, 26, 2927. doi: 10.1016/j.bios.2010.11.039
25. [25]
  Liu, Z.-Y.; Yuan, R.; Chai, Y.-Q.; Zhuo, Y.; Hong, C.-L. Acta Chim. Sinica 2009, 67, 637(in Chinese).
26. [26]
  Xu, S. J.; Liu, Y.; Wang, T. H.; Li, J. H. Anal. Chem. 2011, 83, 3817. doi: 10.1021/ac200237j
27. [27]
  Wang, H. M.; Huang, X. Q.; Yuan, P.; Feng, P. Anal. Chim. Acta 2020, 1104, 53. doi: 10.1016/j.aca.2020.01.009
28. [28]
  Qi, H.; Li, M.; Dong, M. M.; Ruan, S.; Zhang, C. Anal. Chem. 2014, 86, 1372. doi: 10.1021/ac402991r
29. [29]
  Liu, S.; He, P.; Hussain, S.; Lu, H.; Zhou, X.; Lv, F.; Liu, L.; Dai, Z.; Wang, S. ACS Appl. Mater. Interfaces 2018, 10, 6618. doi: 10.1021/acsami.7b18275
30. [30]
  Zhao, J.; Wang, S. P.; Zhang, S. B.; Zhao, P. N.; Wang, J. R.; Yan, M.; Ge, S. G.; Yu, J. H. Biosens. Bioelectron.2020, 150, 111958. doi: 10.1016/j.bios.2019.111958
31. [31]
  Gao, C. M.; Yu, H. H.; Li, C. J.; Cui, K.; Yu, J. H. Anal. Chem. 2020, 92, 2902. doi: 10.1021/acs.analchem.9b05611
32. [32]
  Uludag, Y.; Tothill, I. E. Anal. Chem. 2012, 84, 5898. doi: 10.1021/ac300278p
33. [33]
  Shao, F. Y.; Zhang, L. H.; Jiao, L.; Wang, X. Y.; Miao, L. Y.; Li, H.; Zhou, F. M. Anal. Chem. 2018, 90, 8673. doi: 10.1021/acs.analchem.8b02019
34. [34]
  Kim, H. J.; Jang, C. H. Sens. Actuators, B 2019, 282, 574. doi: 10.1016/j.snb.2018.11.104
35. [35]
  Qi, L.; Hu, Q.; Kang, Q.; Bi, Y.; Jiang, Y.; Yu, L. Anal. Chem. 2019, 91, 11653. doi: 10.1021/acs.analchem.9b02186
36. [36]
  Qi, L. B.; Liu, S. Y.; Jiang, Y. F.; Lin, J. M.; Yu, L.; Hu, Q. Z. Anal. Chem. 2020, 92, 3867. doi: 10.1021/acs.analchem.9b05317
37. [37]
  Savory, N.; Abe, K.; Sode, K.; Ikebukuro, K. Biosens. Bioelectron. 2010, 26, 1386. doi: 10.1016/j.bios.2010.07.057
38. [38]
  Bull, H.; Murray, P. G.; Thomas, D.; Fraser, A.; Nelson, P. N. Mol. Pathol. 2002, 55, 65. doi: 10.1136/mp.55.2.65
39. [39]
  Ozu, C.; Nakashima, J.; Horiguchi, Y.; Oya, M.; Ohigashi, T.; Murai, M. Int. J. Urol. 2008, 15, 419. doi: 10.1111/j.1442-2042.2008.02029.x
40. [40]
  Makarov, D. V.; Loeb, S.; Getzenberg, R. H.; Partin, A. W. Annu. Rev. Med. 2009, 60, 139. doi: 10.1146/annurev.med.60.042307.110714
41. [41]
  Dupont, A.; Cusan, L.; Gomez, J. L. J. Urol. 1991, 146, 1064. doi: 10.1016/S0022-5347(17)38001-1
42. [42]
  Sasamoto, H.; Maeda, M.; Tsuji, A.; Manita, H. Anal. Chim. Acta 1995, 309, 221. doi: 10.1016/0003-2670(95)00084-D
43. [43]
  Hassan, S. S. M.; Sayour, H. E. M.; Kamel, A. H. Anal. Chim. Acta 2009, 640, 75. doi: 10.1016/j.aca.2009.03.019
44. [44]
  Guo, Y. Y.; Li, X. Q.; Dong, Y. M.; Wang, G. L. ACS Sustainable Chem. Eng. 2019, 7, 7572. doi: 10.1021/acssuschemeng.8b05719
45. [45]
  Deng, H. H.; Lin, X. L.; Liu, Y. H.; Li, K. L.; Zhuang, Q. Q.; Peng, H. P.; Liu, A. L.; Xia, X. H.; Chen, W. Nanoscale 2017, 9, 10292. doi: 10.1039/C7NR03399K
46. [46]
  Huang, Y. Y.; Feng, H.; Liu, W. D.; Chen, J. R.; Qian, Z. S. Anal. Chem. 2016, 88, 11575. doi: 10.1021/acs.analchem.6b02957
47. [47]
  Sun, J.; Yang, F.; Yang, X. R. Nanoscale 2015, 7, 16372. doi: 10.1039/C5NR04826E
48. [48]
  Fan, Y. B.; Chen, D. Y. Acta Chim. Sinica 2014, 72, 1012(in Chinese).
49. [49]
  Tian, J. Y.; Yang, Y. T.; Lu, J. S. Biosens. Bioelectron. 2019, 135, 160. doi: 10.1016/j.bios.2019.04.020
50. [50]
  Li, H.; Xing, J. H.; Chen, J. Q. Carbon 2015, 81, 474. doi: 10.1016/j.carbon.2014.09.080
51. [51]
  Li, Z. Z.; Xin, Y. M.; Zhang, Z. H. Anal. Chem. 2015, 87, 10491. doi: 10.1021/acs.analchem.5b02644
52. [52]
  Zhang, H.; Wang, G.; Lv, X. J.; Li, J. H. Chem. Mater. 2008, 20, 6543. doi: 10.1021/cm801796q
53. [53]
  Cao, S. W.; Yu, J. G. J. Phys. Chem. Lett. 2014, 5, 2101. doi: 10.1021/jz500546b
54. [54]
  Hu, S. Z.; Ma, L.; Liu, D.; Gui, J. Z. Appl. Surf. Sci. 2014, 311, 164. doi: 10.1016/j.apsusc.2014.05.036
55. [55]
  Martha, S.; Nashim, A.; Parida, K. M. J. Mater. Chem. A 2013, 1, 7816. doi: 10.1039/c3ta10851a
56. [56]
  Cui, Y. J.; Ding, Z. X.; Wang, X. C. Phys. Chem. Chem. Phys. 2012, 14, 1455. doi: 10.1039/C1CP22820J
57. [57]
  Lu, M. L.; Pei, Z. X.; Zheng, Z. Y.; Huang, M. L.; Liu, P. Phys. Chem. Chem. Phys. 2014, 16, 21280. doi: 10.1039/C4CP02846E
58. [58]
  Sumrra, S. H.; Kausar, S.; Raza, M. A.; Chohan, Z. H. J. Mol. Struct. 2018, 1168, 202. doi: 10.1016/j.molstruc.2018.05.036
59. [59]
  Zhao, S. F.; Gai, P. P.; Yu, W.; Li, H. Y.; Li, F. Chem. Commun. 2019, 55, 1887. doi: 10.1039/C8CC09333D
60. [60]
  Thorum, M. S.; Yadav, J.; Gewirth, A. A. Angew. Chem. Int. Ed. 2009, 48, 165. doi: 10.1002/anie.200803554
61. [61]
  Zou, Q. J.; Kegel, L. L.; Booksh, K. S. Anal. Chem. 2015, 87, 2488. doi: 10.1021/ac504513a
62. [62]
  Huang, M.; Tian, J.; Zhou, C.; Lu, J. Sens. Actuators, B 2020, 307, 127654. doi: 10.1016/j.snb.2020.127654
63. [63]
  Chen, C.; Liu, W.; Li, J.; Lu, Y.; Chen, W. ACS Appl. Mater. Interfaces 2019, 11, 47564. doi: 10.1021/acsami.9b16279
64. [64]
  Lin, Z.; Zhang, X. M.; Liu, S. J.; Chen, R. T.; Lin, X.; Chen, W. Anal. Chim. Acta 2020, 1105, 162. doi: 10.1016/j.aca.2020.01.035
65. [65]
  Qian, Z. S.; Chai, L. J.; Zhou, Q.; Tang, C.; Chen, J. R.; Feng, H. Anal. Chem. 2015, 87, 7332. doi: 10.1021/acs.analchem.5b01488
66. [66]
  Qu, Z. Y.; Na, W. D.; Liu, X. T.; Liu, H.; Su, X. G. Anal. Chim. Acta 2018, 997, 52. doi: 10.1016/j.aca.2017.10.010
67. [67]
  Li, S. Q.; Hua, X.; Chen, Q. M.; Zhang, X. D.; Chai, H. X.; Huang, Y. M. Biosens. Bioelectron. 2019, 137, 133. doi: 10.1016/j.bios.2019.05.010
68. [68]
  Chen, Y. Y.; Wang, Z. Z.; Hao, X. L.; Li, F. L.; Zheng, Y. J.; Zhang, J. Z.; Lin, X. H.; Weng, S. H. Sens. Actuators, B 2019, 297, 126784. doi: 10.1016/j.snb.2019.126784
69. [69]
  Liu, X. J.; Zhang, Y. S.; Liang, A. Y.; Ding, H. W.; Gai, H. W. Chem. Commun. 2019, 55, 11442. doi: 10.1039/C9CC05548G
70. [70]
  Liu, G. L.; Long, Y. T.; Choi, Y.; Kang, T.; Lee, L. P. Nat. Methods 2007, 4, 1015. doi: 10.1038/nmeth1133
71. [71]
  Li, S. S.; Kong, Q. Y.; Zhang, M.; Yang, F.; Kang, B.; Xu, J. J.; Chen, H. Y. Anal. Chem. 2018, 90, 3833. doi: 10.1021/acs.analchem.7b04467
72. [72]
  Choi, Y.; Kang, T.; Lee, L. P. Nano Lett. 2009, 9, 85. doi: 10.1021/nl802511z
73. [73]
  Cao, Y.; Lin, Y.; Qian, R. C.; Ying, Y. L.; Si, W.; Sha, J. J.; Chen, Y. F.; Long, Y. T. Chem. Commun. 2016, 52, 5230. doi: 10.1039/C6CC00694A
74. [74]
  Yan, X.; Xia, C.; Gao, P. F.; Huang, C. Z. Anal. Chem. 2020, 92, 2130. doi: 10.1021/acs.analchem.9b04685
75. [75]
  Zhang, J.; Yuan, Y.; Han, Z.; Liu, G. B. Biosens. Bioelectron. 2019, 141, 111442. doi: 10.1016/j.bios.2019.111442
76. [76]
  Feng, N.; Hu, J. J.; Ma, Q. L.; Ju, H. X. Biosens. Bioelectron. 2020, 157, 112159. doi: 10.1016/j.bios.2020.112159
77. [77]
  Ma, Q. L.; Chen, Y. L.; Feng, N.; Yan, F.; Ju, H. X. Sci. China Chem. 2020, 63, 11426-020-9850-3.
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