Citation: Yan Lin, Ren Yongshuo, Wang Xuejing, Mu Wei, Han Xiaojun. Coacervate and Its Application in the Field of Artificial Cells[J]. Acta Chimica Sinica, ;2020, 78(11): 1150-1163. doi: 10.6023/A20060253 shu

Coacervate and Its Application in the Field of Artificial Cells

State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001

Corresponding author: Mu Wei, muwei@hit.edu.cn Han Xiaojun, hanxiaojun@hit.edu.cn
Received Date: 20 June 2020
Available Online: 5 August 2020
Fund Project: the National Natural Science Foundation of China 21773050the Natural Science Foundation of Heilongjiang Province for Distinguished Young Scholars JC2018003the National Natural Science Foundation of China 21929401Project supported by the National Natural Science Foundation of China (Nos. 21773050, 21929401) and the Natural Science Foundation of Heilongjiang Province for Distinguished Young Scholars (No. JC2018003)

Figures(6)

The origin of life attracts more and more attentions of researchers. Synthetic biologists are devoting to construct a simple and rational system which can exist in primitive earth. Coacervate is a phase separation system which is formed by the interactions of polyelectrolyte. It's a rational protocell model. So far, coacervate has been found to present as membraneless organelles in natural cells. Therefore, the construction of coacervate as artificial organelles is emerging. The formation mechanism, characteristics and categories of coacervate are reviewed in this paper. Additionally, the applications of coacervate as protocell and artificial organelles are summarized. The existing scientific problems and the future development directions are provided at the end of this paper.
- coacervate,
- artificial cells,
- liquid/liquid phase separation,
- electrostatic interaction,
- artificial organelle,
- collective behavior
1. [1]
  Nakashima, K. K.; Vibhute, M. A.; Spruijt, E. Front. Mol. Biosci. 2019, 6, 1. doi: 10.3389/fmolb.2019.00001
2. [2]
  Lau, H. K.; Paul, A.; Sidhu, I.; Li, L.; Sabanayagam, C. R.; Parekh, S. H.; Kiick, K. L. Adv. Sci. 2018, 5, 1701010. doi: 10.1002/advs.201701010
3. [3]
  Kizilay, E.; Kayitmazer, A. B.; Dubin, P. L. Adv. Colloid Interface Sci. 2011, 167, 24. doi: 10.1016/j.cis.2011.06.006
4. [4]
  Bungenberg De Jong, H. G. Ned. Tijdschr. Geneeskd. 1952, 96, 1489.
5. [5]
  Kerfeld, C. A.; Heinhorst, S.; Cannon, G. C. Annu. Rev. Microbiol. 2010, 64, 391. doi: 10.1146/annurev.micro.112408.134211
6. [6]
  Alberti, S. J. Cell Sci. 2017, 130, 2789. doi: 10.1242/jcs.200295
7. [7]
  Gabaldon, T.; Pittis, A. A. Biochimie 2015, 119, 262. doi: 10.1016/j.biochi.2015.03.021
8. [8]
  Heald, R.; Cohen-Fix, O. Curr. Opin. Cell Biol. 2014, 26, 79. doi: 10.1016/j.ceb.2013.10.006
9. [9]
  Sirri, V.; Urcuqui-Inchima, S.; Roussel, P.; Hernandez-Verdun, D. Histochem. Cell Biol. 2008, 129, 13. doi: 10.1007/s00418-007-0359-6
10. [10]
  Crowe, C. D.; Keating, C. D. Interface Focus 2018, 8, 20180032. doi: 10.1098/rsfs.2018.0032
11. [11]
  Aumiller, W. M., Jr.; Davis, B. W.; Keating, C. D. Int. Rev. Cell Mol. Biol. 2014, 307, 109. doi: 10.1016/B978-0-12-800046-5.00005-9
12. [12]
  Shin, Y.; Brangwynne, C. P. Science 2017, 357, eaaf4382. doi: 10.1126/science.aaf4382
13. [13]
  Banani, S. F.; Lee, H. O.; Hyman, A. A.; Rosen, M. K. Nat. Rev. Mol. Cell Biol. 2017, 18, 285. doi: 10.1038/nrm.2017.7
14. [14]
  Boisvert, F. M.; van Koningsbruggen, S.; Navascues, J.; Lamond, A. I. Nat. Rev. Mol. Cell Biol. 2007, 8, 574.
15. [15]
  Gall, J. G. Nat. Rev. Mol. Cell Biol. 2003, 4, 975. doi: 10.1038/nrm1262
16. [16]
  Jain, S.; Wheeler, J. R.; Walters, R. W.; Agrawal, A.; Barsic, A.; Parker, R. Cell 2016, 164, 487. doi: 10.1016/j.cell.2015.12.038
17. [17]
  Brangwynne, C. P.; Eckmann, C. R.; Courson, D. S.; Rybarska, A.; Hoege, C.; Gharakhani, J.; Julicher, F.; Hyman, A. A. Science 2009, 324, 1729. doi: 10.1126/science.1172046
18. [18]
  Iwashita, K.; Handa, A.; Shiraki, K. Int. J. Biol. Macromol. 2018, 120, 10. doi: 10.1016/j.ijbiomac.2018.08.063
19. [19]
  Franzmann, T. M.; Jahnel, M.; Pozniakovsky, A.; Mahamid, J.; Holehouse, A. S.; Nuske, E.; Richter, D.; Baumeister, W.; Grill, S. W.; Pappu, R. V.; Hyman, A. A.; Alberti, S. Science 2018, 359, eaao5654. doi: 10.1126/science.aao5654
20. [20]
  Anderson, P.; Kedersha, N. Trends Biochem. Sci. 2008, 33, 141. doi: 10.1016/j.tibs.2007.12.003
21. [21]
  French, J. B.; Jones, S. A.; Deng, H. Y.; Pedley, A. M.; Kim, D.; Chan, C. Y.; Hu, H. B.; Pugh, R. J.; Zhao, H.; Zhang, Y. X.; Huang, T. J.; Fang, Y.; Zhuang, X. W.; Benkovic, S. J. Science 2016, 351, 733. doi: 10.1126/science.aac6054
22. [22]
  Alberti, S.; Gladfelter, A.; Mittag, T. Cell 2019, 176, 419. doi: 10.1016/j.cell.2018.12.035
23. [23]
  Lentini, R.; Yeh Martin, N.; Mansy, S. S. Curr. Opin. Chem. Biol. 2016, 34, 53. doi: 10.1016/j.cbpa.2016.06.013
24. [24]
  Aufinger, L.; Simmel, F. C. Chem. Eur. J. 2019, 25, 12659. doi: 10.1002/chem.201901726
25. [25]
  Engelhart, A. E.; Adamala, K. P.; Szostak, J. W. Nat. Chem. 2016, 8, 448. doi: 10.1038/nchem.2475
26. [26]
  Budin, I.; Debnath, A.; Szostak, J. W. J. Am. Chem. Soc. 2012, 134, 20812. doi: 10.1021/ja310382d
27. [27]
  Zong, W.; Ma, S. H.; Zhang, X. N.; Wang, X. J.; Li, Q. C.; Han, X. J. J. Am. Chem. Soc. 2017, 139, 9955. doi: 10.1021/jacs.7b04009
28. [28]
  Zong, W.; Zhang, X. N.; Li, C.; Han, X. J. ACS Synth. Biol. 2018, 7, 945. doi: 10.1021/acssynbio.8b00045
29. [29]
  Li, S. B.; Wang, X. J.; Mu, W.; Han, X. J. Anal. Chem. 2019, 91, 6859.
30. [30]
  Kamiya, K.; Takeuchi, S. J. Mat. Chem. B 2017, 5, 5911. doi: 10.1039/C7TB01322A
31. [31]
  Dupin, A.; Simmel, F. C. Nat. Chem. 2019, 11, 32. doi: 10.1038/s41557-018-0174-9
32. [32]
  van Swaay, D.; deMello, A. Lab Chip 2013, 13, 752. doi: 10.1039/c2lc41121k
33. [33]
  Li, Q. C.; Wang, X. J.; Ma, S. H.; Zhang, Y.; Han, X. J. Colloids Surf. B-Biointerfaces 2016, 147, 368. doi: 10.1016/j.colsurfb.2016.08.018
34. [34]
  Tian, W.; Sasaki, Y.; Ikeda, A.; Kikuchi, J.; Song, X.; Fan, S. Acta Chim. Sinica 2004, 62, 1230(in Chinese).
35. [35]
  Li, L.; Lin, M.; Qiu, F.; Yang, Y. Acta Chim. Sinica 2005, 63, 1375(in Chinese).
36. [36]
  Meng, F. H.; Zhong, Z. Y. J. Phys. Chem. Lett. 2011, 2, 1533. doi: 10.1021/jz200007h
37. [37]
  LoPresti, C.; Lomas, H.; Massignani, M.; Smart, T.; Battaglia, G. J. Mater. Chem. 2009, 19, 3576. doi: 10.1039/b818869f
38. [38]
  Oparin, A. I. Origin of Life, Dover Publications, New York, 1953.
39. [39]
  Poudyal, R. R.; Pir Cakmak, F.; Keating, C. D.; Bevilacqua, P. C. Biochemistry 2018, 57, 2509. doi: 10.1021/acs.biochem.8b00081
40. [40]
  Overbeek, J. T.; Voorn, M. J. J. Cell. Physiol. 1957, 49, 7. doi: 10.1002/jcp.1030490404
41. [41]
  Kim, S.; Huang, J.; Lee, Y.; Dutta, S.; Yoo, H. Y.; Jung, Y. M.; Jho, Y.; Zeng, H.; Hwang, D. S. Proc. Natl. Acad. Sci. 2016, 113, E847. doi: 10.1073/pnas.1521521113
42. [42]
  Hoffmann, K. Q.; Perry, S. L.; Leon, L.; Priftis, D.; Tirrell, M.; de Pablo, J. J. Soft Matter 2015, 11, 1525. doi: 10.1039/C4SM02336F
43. [43]
  Roy, D.; Brooks, W. L. A.; Sumerlin, B. S. Chem. Soc. Rev. 2013, 42, 7214. doi: 10.1039/c3cs35499g
44. [44]
  Blocher, W. C.; Perry, S. L. Wiley Interdiscip. Rev.:Nanomed. Nanobiotechnol. 2017, 9, e1442. doi: 10.1002/wnan.1442
45. [45]
  Priftis, D.; Xia, X.; Margossian, K. O.; Perry, S. L.; Leon, L.; Qin, J.; de Pablo, J. J.; Tirrell, M. Macromolecules 2014, 47, 3076. doi: 10.1021/ma500245j
46. [46]
  Jeon, B. J.; Nguyen, D. T.; Abraham, G. R.; Conrad, N.; Fygenson, D. K.; Saleh, O. A. Soft Matter 2018, 14, 7009. doi: 10.1039/C8SM01085D
47. [47]
  Schuster, B. S.; Reed, E. H.; Parthasarathy, R.; Jahnke, C. N.; Caldwell, R. M.; Bermudez, J. G.; Ramage, H.; Good, M. C.; Hammer, D. A. Nat. Commun. 2018, 9, 12. doi: 10.1038/s41467-017-02416-0
48. [48]
  Deng, N.-N.; Huck W. T. S. Angew. Chem. Int. Ed. 2017, 56, 9736. doi: 10.1002/anie.201703145
49. [49]
  Koga, S.; Williams, D. S.; Perriman, A. W.; Mann, S. Nat. Chem. 2011, 3, 720. doi: 10.1038/nchem.1110
50. [50]
  Black, K. A.; Priftis, D.; Perry, S. L.; Yip, J.; Byun, W. Y.; Tirrell, M. ACS Macro Lett. 2014, 3, 1088. doi: 10.1021/mz500529v
51. [51]
  Aumiller, W. M., Jr.; Keating, C. D. Nat. Chem. 2016, 8, 129. doi: 10.1038/nchem.2414
52. [52]
  Spruijt, E.; Sprakel, J.; Stuart, M. A. C.; van der Gucht, J. Soft Matter 2010, 6, 172. doi: 10.1039/B911541B
53. [53]
  Frankel, E. A.; Bevilacqua, P. C.; Keating, C. D. Langmuir 2016, 32, 2041. doi: 10.1021/acs.langmuir.5b04462
54. [54]
  Zhao, M. M.; Zacharia, N. S. J. Chem. Phys. 2018, 149, 163326. doi: 10.1063/1.5040346
55. [55]
  Lindhoud, S.; Claessens, M. M. A. E. Soft Matter 2016, 12, 408. doi: 10.1039/C5SM02386F
56. [56]
  Obermeyer, A. C.; Mills, C. E.; Dong, X. H.; Flores, R. J.; Olsen, B. D. Soft Matter 2016, 12, 3570. doi: 10.1039/C6SM00002A
57. [57]
  Kapelner, R. A.; Obermeyer, A. C. Chem. Sci. 2019, 10, 2700. doi: 10.1039/C8SC04253E
58. [58]
  Cummings, C. S.; Obermeyer, A. C. Biochemistry 2018, 57, 314. doi: 10.1021/acs.biochem.7b00990
59. [59]
  Horn, J. M.; Kapelner, R. A.; Obermeyer, A. C. Polymers 2019, 11, 578. doi: 10.3390/polym11040578
60. [60]
  Pathak, J.; Rawat, K. RSC Adv. 2015, 5, 67066. doi: 10.1039/C5RA07195J
61. [61]
  Pathak, J.; Rawat, K. J. Phys. Chem. B 2014, 118, 11161. doi: 10.1021/jp5068846
62. [62]
  Perry, S. L.; Leon, L.; Hoffmann, K. Q.; Kade, M. J.; Priftis, D.; Black, K. A.; Wong, D.; Klein, R. A.; Pierce, C. F.; Margossian, K. O.; Whitmer, J. K.; Qin, J.; de Pablo, J. J.; Tirrell, M. Nat. Commun. 2015, 6, 8.
63. [63]
  Aumiller, W. M., Jr.; Keating, C. D. Adv. Colloid Interface Sci. 2017, 239, 75. doi: 10.1016/j.cis.2016.06.011
64. [64]
  Souza, C. J. F.; da Costa, A. R.; Souza, C. F.; Tosin, F. F. S.; Garcia-Rojas, E. E. Int. J. Biol. Macromol. 2018, 107, 1253. doi: 10.1016/j.ijbiomac.2017.09.104
65. [65]
  Souza, C. J. F.; Garcia-Rojas, E. E. Food Hydrocoll. 2015, 47, 124. doi: 10.1016/j.foodhyd.2015.01.010
66. [66]
  Hwang, D. S.; Zeng, H. B.; Srivastava, A.; Krogstad, D. V.; Tirrell, M.; Israelachvili, J. N.; Waite, J. H. Soft Matter 2010, 6, 3232. doi: 10.1039/c002632h
67. [67]
  Zhang, X. M.; Lin, Y. X.; Eschmann, N. A.; Zhou, H. J.; Rauch, J. N.; Hernandez, I.; Guzman, E.; Kosik, K. S.; Han, S. I. PLoS Biol. 2017, 15, 28.
68. [68]
  Mason, A. F.; Buddingh, B. C.; Williams, D. S.; van Hest, J. C. M. J. Am. Chem. Soc. 2017, 139, 17309. doi: 10.1021/jacs.7b10846
69. [69]
  Mason, A. F.; Yewdall, N. A.; Welzen, P. L. W.; Shao, J.; van Stevendaal, M.; van Hest, J. C. M.; Williams, D. S.; Abdelmohsen, L. ACS Cent. Sci. 2019, 5, 1360. doi: 10.1021/acscentsci.9b00345
70. [70]
  Qiao, Y.; Li, M.; Booth, R.; Mann, S. Nat. Chem. 2017, 9, 110. doi: 10.1038/nchem.2617
71. [71]
  Dora Tang, T. Y.; Rohaida Che Hak, C.; Thompson, A. J.; Kuimova, M. K.; Williams, D. S.; Perriman, A. W.; Mann, S. Nat. Chem. 2014, 6, 527. doi: 10.1038/nchem.1921
72. [72]
  Priftis, D.; Farina, R.; Tirrell, M. Langmuir 2012, 28, 8721. doi: 10.1021/la300769d
73. [73]
  Lu, T.; Spruijt, E. J. Am. Chem. Soc. 2020, 142, 2905. doi: 10.1021/jacs.9b11468
74. [74]
  Ulijn, R. V.; Lampel, A. Isr. J. Chem. 2019, 1.
75. [75]
  Choi, J.-M.; Wang, J.; Holehouse, A. S.; Alberti, S.; Hyman, A. A.; Pappu, R. V. Biophys. J. 2018, 114, 561A.
76. [76]
  Wei, M.-T.; Elbaum-Garfinkle, S.; Holehouse, A. S.; Chen, C. C.-H.; Feric, M.; Arnold, C. B.; Priestley, R. D.; Pappu, R. V.; Brangwynne, C. P. Nat. Chem. 2017, 9, 1118. doi: 10.1038/nchem.2803
77. [77]
  Oldfield, C. J.; Dunker, A. K. Annu. Rev. Biochem. 2014, 83, 553. doi: 10.1146/annurev-biochem-072711-164947
78. [78]
  Cohan, M. C.; Posey, A. E.; Mittal, A.; Grigsby, S. J.; Holehouse, A. S.; Buske, P. J.; Levin, P. A.; Pappu, R. V. Mol. Biol. Cell 2017, 114, 590A.
79. [79]
  Harmon, T. S.; Holehouse, A. S.; Pappu, R. V. New J. Phys. 2018, 20, 045002. doi: 10.1088/1367-2630/aab8d9
80. [80]
  Ruff, K. M.; Pappu, R. V.; Holehouse, A. S. Curr. Opin. Struct. Biol. 2019, 56, 1.
81. [81]
  Molliex, A.; Temirov, J.; Lee, J.; Coughlin, M.; Kanagaraj, A. P.; Kim, H. J.; Mittag, T.; Taylor, J. P. Cell 2015, 163, 123. doi: 10.1016/j.cell.2015.09.015
82. [82]
  Elbaum-Garfinkle, S.; Kim, Y.; Szczepaniak, K.; Chen, C. C. H.; Eckmann, C. R.; Myong, S.; Brangwynne, C. P. Proc. Natl. Acad. Sci. 2015, 112, 7189. doi: 10.1073/pnas.1504822112
83. [83]
  Tan, Y. P.; Hoon, S.; Guerette, P. A.; Wei, W.; Ghadban, A.; Hao, C.; Miserez, A.; Waite, J. H. Nat. Chem. Biol. 2015, 11, 488. doi: 10.1038/nchembio.1833
84. [84]
  Madinya, J. J.; Chang, L. W.; Perry, S. L.; Sing, C. E. Mol. Syst. Des. Eng. 2020, 5, 632. doi: 10.1039/C9ME00074G
85. [85]
  Mountain, G. A.; Keating, C. D. Biomacromolecules 2020, 21, 630. doi: 10.1021/acs.biomac.9b01354
86. [86]
  Jing, H.; Bai, Q.; Lin, Y. n.; Chang, H.; Yin, D.; Liang, D. Langmuir 2020, 36, 8017. doi: 10.1021/acs.langmuir.0c01864
87. [87]
  Yin, Y. D.; Niu, L.; Zhu, X. C.; Zhao, M. P.; Zhang, Z. X.; Mann, S.; Liang, D. H. Nat. Commun. 2016, 7, 7.
88. [88]
  Yin, Y. D.; Chang, H. J.; Jing, H. R.; Zhang, Z. X.; Yan, D. D.; Mann, S.; Liang, D. H. Soft Matter 2018, 14, 6514. doi: 10.1039/C8SM01168K
89. [89]
  Fothergill, J.; Li, M.; Davis, S. A.; Cunningham, J. A.; Mann, S. Langmuir 2014, 30, 14591. doi: 10.1021/la503746u
90. [90]
  Dompe, M.; Cedano-Serrano, F. J.; Heckert, O.; van den Heuvel, N.; van der Gucht, J.; Tran, Y.; Hourdet, D.; Creton, C.; Kamperman, M. Adv. Mater. 2019, 31, e1808179. doi: 10.1002/adma.201808179
91. [91]
  Kumar, B.; Fothergill, J.; Bretherton, J.; Tian, L. F.; Patil, A. J.; Davis, S. A.; Mann, S. Chem. Commun. 2018, 54, 3594. doi: 10.1039/C8CC01129J
92. [92]
  Lawrence, M. S.; Phillips, K. J.; Liu, D. R. J. Am. Chem. Soc. 2007, 129, 10110. doi: 10.1021/ja071641y
93. [93]
  Comert, F.; Malanowski, A. J.; Azarikia, F.; Dubin, P. L. Soft Matter 2016, 12, 4154. doi: 10.1039/C6SM00044D
94. [94]
  Comert, F.; Xu, A. Y.; Madro, S. P.; Liadinskaia, V.; Dubin, P. L. J. Chem. Phys. 2018, 149, 163321. doi: 10.1063/1.5029296
95. [95]
  Xu, A. Y.; Melton, L. D.; Ryan, T. M.; Mata, J. P.; Rekas, A.; Williams, M. A. K.; McGillivray, D. J. Food Hydrocoll. 2018, 77, 952. doi: 10.1016/j.foodhyd.2017.11.045
96. [96]
  Pandey, P. K.; Kaushik, P.; Rawat, K.; Aswal, V. K.; Bohidar, H. B. Soft Matter 2017, 13, 6784. doi: 10.1039/C7SM01222E
97. [97]
  Lin, Y.; Jing, H.; Liu, Z.; Chen, J.; Liang, D. Langmuir 2020, 36, 1709. doi: 10.1021/acs.langmuir.9b03561
98. [98]
  Simon, J. R.; Carroll, N. J.; Rubinstein, M.; Chilkoti, A.; Lopez, G. P. Nat. Chem. 2017, 9, 509. doi: 10.1038/nchem.2715
99. [99]
  Reed, E. H.; Schuster, B. S. ACS Synth. Biol. 2020, 9, 500. doi: 10.1021/acssynbio.9b00503
100. [100]
  Shin, Y.; Berry, J.; Pannucci, N.; Haataja, M. P.; Toettcher, J. E.; Brangwynne, C. P. Cell 2017, 168, 159. doi: 10.1016/j.cell.2016.11.054
101. [101]
  Mitrea, D. M.; Kriwacki, R. W. Cell Commun. Signaling 2016, 14, R1097.
102. [102]
  Bayley, H.; Mason, A. F.; van Hest, J. C. M. Emerging Top. Life Sci. 2019, 3, 567. doi: 10.1042/ETLS20190094
103. [103]
  Ghellab, S. E.; Li, Q. C.; Fuhs, T.; Bi, H. M.; Han, X. J. Colloid Surf. B-Biointerfaces 2017, 160, 697. doi: 10.1016/j.colsurfb.2017.10.025
104. [104]
  Spoelstra, W. K.; Deshpande, S.; Dekker, C. Curr. Opin. Biotechnol. 2018, 51, 47. doi: 10.1016/j.copbio.2017.11.005
105. [105]
  Blain, J. C.; Szostak, J. W. Annu. Rev. Biochem. 2014, 83, 615. doi: 10.1146/annurev-biochem-080411-124036
106. [106]
  Vance, J. E. Traffic 2015, 16, 1. doi: 10.1111/tra.12230
107. [107]
  Zhang, Y. M.; Rock, C. O. Nat. Rev. Microbiol. 2008, 6, 222. doi: 10.1038/nrmicro1839
108. [108]
  Hansen, J. S.; Elbing, K.; Thompson, J. R.; Malmstadt, N.; Lindkvist-Petersson, K. Chem. Commun. 2015, 51, 2316. doi: 10.1039/C4CC08838G
109. [109]
  Nordlund, G.; Brzezinski, P.; von Ballmoos, C. Nat. Commun. 2014, 5, 8.
110. [110]
  Lee, K. Y.; Park, S. J.; Lee, K. A.; Kim, S. H.; Kim, H.; Meroz, Y.; Mahadevan, L.; Jung, K. H.; Ahn, T. K.; Parker, K. K.; Shin, K. Nat. Biotechnol. 2018, 36, 530. doi: 10.1038/nbt.4140
111. [111]
  Sokolova, E.; Spruijt, E.; Hansen, M. M. K.; Dubuc, E.; Groen, J.; Chokkalingam, V.; Piruska, A.; Heus, H. A.; Huck, W. T. S. Proc. Natl. Acad. Sci. 2013, 110, 11692. doi: 10.1073/pnas.1222321110
112. [112]
  Booth, R.; Qiao, Y.; Li, M.; Mann, S. Angew. Chem. Int. Ed. 2019, 3, 1.
113. [113]
  Last, M. G. F.; Deshpande, S.; Dekker, C. ACS Nano 2020, 14, 4487. doi: 10.1021/acsnano.9b10167
114. [114]
  Sato, Y.; Takinoue, M. Micromachines 2019, 10, 216. doi: 10.3390/mi10040216
115. [115]
  Linsenmeier, M.; Kopp, M. R. G.; Grigolato, F.; Liu, D.; Zuercher, D.; Hondele, M.; Weis, K.; Palmiero, U. C.; Arosio, P. Angew. Chem. Int. Ed. 2019, 58, 14489. doi: 10.1002/anie.201907278
116. [116]
  Love, C.; Steinkuhler, J.; Gonzales, D. T.; Yandrapalli, N.; Robinson, T.; Dimova, R.; Tang, T. D. Angew. Chem. Int. Ed. 2020, 59, 5950. doi: 10.1002/anie.201914893
117. [117]
  Deshpande, S.; Brandenburg, F.; Lau, A.; Last, M. G. F.; Spoelstra, W. K.; Reese, L.; Wunnava, S.; Dogterom, M.; Dekker, C. Nat. Commun. 2019, 10, 1800. doi: 10.1038/s41467-019-09855-x
118. [118]
  Shin, Y.; Berry, J.; Pannucci, N.; Haataja, M. P.; Toettcher, J. E.; Brangwynne, C. P. Cell 2017, 168, 159. doi: 10.1016/j.cell.2016.11.054
119. [119]
  Yewdall, N. A.; Mason, A. F.; van Hest, J. C. M. Interface Focus 2018, 8, 15.
120. [120]
  Zwicker, D.; Seyboldt, R.; Weber, C. A.; Hyman, A. A.; Jülicher, F. Nat. Phys. 2016, 13, 408.
121. [121]
  Tang, T. Y. D.; van Swaay, D.; deMello, A.; Anderson, J. L. R.; Mann, S. Chem. Commun. 2015, 51, 11429. doi: 10.1039/C5CC04220H
122. [122]
  Deng, N.-N.; Vibhute, M. A.; Zheng, L.; Zhao, H.; Yelleswarapu, M.; Huck, W. T. S. J. Am. Chem. Soc. 2018, 140, 7399. doi: 10.1021/jacs.8b03123
123. [123]
  Krishna Kumar, R.; Yu, X.; Patil, A. J.; Li, M.; Mann, S. Angew. Chem. Int. Ed. 2011, 50, 9343. doi: 10.1002/anie.201102628
124. [124]
  Dzieciol, A. J.; Mann, S. Chem. Soc. Rev. 2012, 41, 79. doi: 10.1039/C1CS15211D
125. [125]
  Chatterjee, S.; Yadav, S. Life 2019, 9, 1.
126. [126]
  Strulson, C. A.; Molden, R. C.; Keating, C. D.; Bevilacqua, P. C. Nat. Chem. 2012, 4, 941. doi: 10.1038/nchem.1466
127. [127]
  Drobot, B.; Iglesias-Artola, J. M.; Le Vay, K.; Mayr, V.; Kar, M.; Kreysing, M.; Mutschler, H.; Tang, T. D. Nat. Commun. 2018, 9, 3643. doi: 10.1038/s41467-018-06072-w
128. [128]
  Poudyal, R. R.; Guth-Metzler, R. M.; Veenis, A. J.; Frankel, E. A.; Keating, C. D.; Bevilacqua, P. C. Nat. Commun. 2019, 10, 490. doi: 10.1038/s41467-019-08353-4
129. [129]
  Tang, T. Y. D.; Antognozzi, M.; Vicary, J. A.; Perriman, A. W.; Mann, S. Soft Matter 2013, 9, 7647. doi: 10.1039/c3sm50726b
130. [130]
  Pir Cakmak, F.; Grigas, A. T.; Keating, C. D. Langmuir 2019, 35, 7830. doi: 10.1021/acs.langmuir.9b00213
131. [131]
  Martin, N.; Douliez, J. P. Angew. Chem. Int. Ed. 2017, 56, 13689. doi: 10.1002/anie.201707139
132. [132]
  Williams, D. S.; Patil, A. J.; Mann, S. Small 2014, 10, 1830. doi: 10.1002/smll.201303654
133. [133]
  Byun, C. K.; Hwang, H.; Choi, W. S.; Yaguchi, T.; Park, J.; Kim, D.; Mitchell, R. J.; Kim, T.; Cho, Y. K.; Takayama, S. J. Am. Chem. Soc. 2013, 135, 2242. doi: 10.1021/ja3094923
134. [134]
  Zhu, C. T.; Li, Q. C.; Dong, M. D.; Han, X. J. Anal. Chem. 2018, 90, 14363. doi: 10.1021/acs.analchem.8b03825
135. [135]
  Wang, X. J.; Tian, L. F.; Du, H.; Li, M.; Mu, W.; Drinkwater, B. W.; Han, X. J.; Mann, S. Chem. Sci. 2019, 10, 9446. doi: 10.1039/C9SC04522H
136. [136]
  Magdalena Estirado, E.; Mason, A. F.; Alemán García, M. Á.; van Hest, J. C. M.; Brunsveld, L. J. Am. Chem. Soc. 2020, 142, 9106. doi: 10.1021/jacs.0c01732
137. [137]
  Tian, L.; Martin, N.; Bassindale, P. G.; Patil, A. J.; Li, M.; Barnes, A.; Drinkwater, B. W.; Mann, S. Nat. Commun. 2016, 7, 13068. doi: 10.1038/ncomms13068
138. [138]
  Tian, L. F.; Li, M.; Liu, J. T.; Patil, A. J.; Drinkwater, B. W.; Mann, S. ACS Cent. Sci. 2018, 4, 1551. doi: 10.1021/acscentsci.8b00555
139. [139]
  Tian, L. F.; Li, M.; Patil, A. J.; Drinkwater, B. W.; Mann, S. Nat. Commun. 2019, 10, 13. doi: 10.1038/s41467-018-07689-7
140. [140]
  Martin, N.; Douliez, J. P.; Qiao, Y.; Booth, R.; Li, M.; Mann, S. Nat. Commun. 2018, 9, 3652. doi: 10.1038/s41467-018-06087-3
141. [141]
  Qiao, Y.; Li, M.; Qiu, D.; Mann, S. Angew. Chem. Int. Ed. 2019, 58, 17758. doi: 10.1002/anie.201909313
142. [142]
  Zhang, Y. W.; Liu, S. Y.; Yao, Y.; Chen, Y. F.; Zhou, S. H.; Yang, X. H.; Wang, K.; Liu, J. B. Small 2020, 16, 2002073. doi: 10.1002/smll.202002073
143. [143]
  Liu, J.; Tian, L.; Mann, S. Angew. Chem. Int. Ed. 2019, 59, 6853.
144. [144]
  Zimmerman, S. B.; Harrison, B. Proc. Natl. Acad. Sci. 1987, 84, 1871. doi: 10.1073/pnas.84.7.1871
145. [145]
  Minton, A. P. J. Cell Sci. 2006, 119, 2863. doi: 10.1242/jcs.03063
146. [146]
  te Brinke, E.; Groen, J.; Herrmann, A.; Heus, H. A.; Rivas, G.; Spruijt, E.; Huck, W. T. S. Nat. Nanotechnol. 2018, 13, 849. doi: 10.1038/s41565-018-0192-1
147. [147]
  Zwicker, D.; Seyboldt, R.; Weber, C. A.; Hyman, A. A.; Julicher, F. Nat. Phys. 2017, 13, 408. doi: 10.1038/nphys3984
148. [148]
  Spoelstra, W. K.; van der Sluis, E. O.; Dogterom, M.; Reese, L. Langmuir 2020, 36, 1956. doi: 10.1021/acs.langmuir.9b02719
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