Citation: Jia Yiyi, Wang Wenjie, Liang Ling, Yuan Quan. Bioassay Applications of Aptamer-Functionalized Rare Earth Nanomaterials[J]. Acta Chimica Sinica, ;2020, 78(11): 1177-1184. doi: 10.6023/A20060252 shu

Bioassay Applications of Aptamer-Functionalized Rare Earth Nanomaterials

Institute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

Corresponding author: Yuan Quan, yuanquan@whu.edu.cn

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Received Date: 19 June 2020
Available Online: 27 July 2020
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21904037), Natural Science Foundation of Hunan Province, China (Nos. 2020JJ4173, 2020JJ5038) and Changsha Municipal Science and Technology Projects, China (No. Kq1901030)Natural Science Foundation of Hunan Province, China 2020JJ4173Changsha Municipal Science and Technology Projects, China Kq1901030the National Natural Science Foundation of China 21904037Natural Science Foundation of Hunan Province, China 2020JJ5038

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The levels of some biomolecules and ions in the body are usually related to the structural and functional changes of cells, tissues, organs, etc., which directly affect the prevention, diagnosis, and treatment of diseases. Therefore, in vivo bioassays of these substances are of great significance in medical and healthcare fields. The nano fluorescent probes consisted of rare earth nano materials have advantages of high sensitivity, simplicity, efficiency, and strong anti-interference ability, thus showing great potential in bioassays. The functionalization of aptamers on rare earth nanomaterials can further provide better specific recognition ability and biocompatibility for nano fluorescent probes, thereby enhancing their bioassays ability in complex samples. In this paper, the research progress of aptamer-functionalized rare earth nanomaterials as nano fluorescent probes in the field of bioassays is reviewed, and the main types, properties, detection mechanisms and detection substances are briefly introduced.
- biomolecule,
- bioassay,
- fluorescent probe,
- nanomaterial,
- rare earth,
- aptamer
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