Citation: Sang Ruoyu, Xu Xingpeng, Wang Qi, Fan Quli, Huang Wei. Near-Infrared-II Fluorescence Probes Based on Organic Small Molecules[J]. Acta Chimica Sinica, ;2020, 78(9): 901-915. doi: 10.6023/A20050190 shu

Near-Infrared-II Fluorescence Probes Based on Organic Small Molecules

Sang Ruoyu ^a ,
Xu Xingpeng ^a ,
Wang Qi ^a,b,, ,
Fan Quli ^a,, ,
Huang Wei ^c

a.
Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing 210023, China;
b.
State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China
c.
Institute of Flexible Electronics, Northwestern Polytechnical University, Xi'an 710072, China

Corresponding author: Wang Qi, iamqwang@njupt.edu.cn Fan Quli, iamqlfan@njupt.edu.cn
Received Date: 28 May 2020
Available Online: 11 July 2016
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21602112, 21674048) and the Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University (No. OPSKLB202006).the Open Research Fund of State Key Laboratory of Bioelectronics, Southeast University OPSKLB202006the National Natural Science Foundation of China 21674048the National Natural Science Foundation of China 21602112

Figures(22)

Fluorescence imaging plays an important role in the diagnosis and treatment of major diseases by virtue of its high sensitivity, strong specificity and excellent spatio-temporal resolution. However, traditional near-infrared-I (NIR-I, 700~900 nm) fluorescence imaging often encounters multiple concerns such as poor tissue penetration, which limits its clinical application. In recent years, near-infrared-II (NIR-II, 1000~1700 nm) fluorescence imaging has been proven to provide better imaging qualities, higher signal-to-noise ratio and deeper tissue penetration than those observed in the NIR-I window due to the diminished photon scattering and tissue auto-fluorescence. Among NIR-II fluorescent probes, organic small molecules are becoming research hotspots in this field due to their advantages of low toxicity, simple structure and fast metabolism. This review describes the recent progress in the design of organic small molecule NIR-II probes and the strategies for improving the fluorescence quantum yield. The application of small molecule NIR-II probes in activatable imaging, multimode imaging and theranostics are evaluated systematically. Current challenges and future perspectives in this emerging field are also prospected.
- near-infrared-II fluorescence imaging,
- organic small molecules,
- activatable probe,
- multimodal imaging,
- phototherapy
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沈阳化工大学材料科学与工程学院沈阳 110142