Citation: Luo Xingrui, Chen Minwen, Yang Qinglai. Research Progress on Near Infrared Ⅱ Technology for in Vivo Imaging[J]. Acta Chimica Sinica, ;2020, 78(5): 373-381. doi: 10.6023/A20020045 shu

Research Progress on Near Infrared Ⅱ Technology for in Vivo Imaging

Luo Xingrui ^a,b ,
Chen Minwen ^c,, ,
Yang Qinglai ^a,b,c,,

a.
Cancer Research Institute of Medical College, and Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001
b.
Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127
c.
Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057

Corresponding author: Chen Minwen, ncuedu@126.com Yang Qinglai, qingyu513@126.com
Received Date: 26 February 2020
Available Online: 10 April 2020
Fund Project: Shenzhen Basic Research Funding JCYJ20170817152825894the National Natural Science Foundation of China 81801749Project supported by the National Natural Science Foundation of China (No. 81801749) and Shenzhen Basic Research Funding (Nos. JCYJ20170307151634428, JCYJ20170817152825894)Shenzhen Basic Research Funding JCYJ20170307151634428

Figures(9)

Near infrared Ⅱ (NIR Ⅱ, 1000~1700 nm) biological imaging, as a new developing optical imaging technology in recent years, has longer fluorescence wavelength compared with the traditional near infrared Ⅰ (NIR Ⅰ, 750~900 nm) and visible light (Vis, 400~750 nm) imaging. Due to the longer emission wavelength, weaker interference by light scattering and tissue autofluorescence, result in higher temporal and spatial resolution with deeper tissue penetration. This technology is more suitable for in vivo imaging in situ. In this review, we mainly introduced research progress on NIR Ⅱ instrument technology for in vivo imaging, and summarized its major features. Finally, we provided a prospect that the development of chemical materials, optoelectronic instruments, and multi-modal technologies can promote NIR Ⅱ technology innovation, which is expected to be widely and deeply applied in clinical transformation.
- near infrared Ⅱ,
- fluorescent probe,
- in vivo imaging,
- clinical transformation
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沈阳化工大学材料科学与工程学院沈阳 110142