Citation: Geng Huimin, Cui Jiwei, Hao Jingcheng. Mussel-Inspired Hydrogels for Tissue Healing[J]. Acta Chimica Sinica, ;2020, 78(2): 105-113. doi: 10.6023/A19080301 shu

Mussel-Inspired Hydrogels for Tissue Healing

Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, Shandong University, Jinan 250100

Corresponding author: Cui Jiwei, jwcui@sdu.edu.cn Hao Jingcheng, jhao@sdu.edu.cn
Received Date: 11 January 2020
Available Online: 13 February 2020
Fund Project: the Natural Science Foundation of Shandong Province ZR2018ZA0547the National Natural Science Foundation of China 21872085Project supported by the National Natural Science Foundation of China (Nos. 21603120, 21872085) and the Natural Science Foundation of Shandong Province (Nos. ZR2018ZA0547, ZR2019BB056)the National Natural Science Foundation of China 21603120the Natural Science Foundation of Shandong Province ZR2019BB056

Figures(8)

Surgical sutures, staples and clips have been widely used for wound closure, tissue reconstruction and tissue adhesives are one of the versatile alternatives especially for friable tissues. Some synthetic and semisynthetic tissue adhesives are available elsewhere. However, there are some drawbacks, such as poor adhesion on wet substrates and potential toxicity, for the reported tissue adhesives. Fibrin glues as biological tissue adhesives are effective hemostatic agents while presenting relatively weak tensile and adhesion strengths and being expensive. Biomimetic adhesives as tissue adhesives, hemostatic agents, or tissue sealants have attracted great attention for clinical operations in last three decades. However, engineering of bio-adhesive materials with good water resistance, high adhesive strength, and good biocompatibility and multi-functionality remains a challenge for tissue healing. Since the first report of mussel-inspired surface chemistry for functional coatings of polydopamine by the Messersmith group in 2007, materials containing plenty of phenolic hydroxyl groups have been widely used in medical applications, food, cosmetics, water treatment and so on, due to the antioxidant, antibacterial, and anti-inflammatory effects of polyphenols. Polyphenol-based hydrogel is an ideal bio-adhesive material due to its good tissue adhesion even on wet substrates, hemostatic and antimicrobial capabilities. Moreover, these hydrogels with porous structures have similar physiochemical properties to that of natural extracellular matrix and different shapes from nanometer to centimeter scales can be remolded to seal irregular defects on tissues. In this review, we report the recent progress of the engineering of polyphenol-synthetic polymer hydrogels, polyphenol-biomacromolecule hydrogels, polyphenol-inorganic nanocomposite hydrogels, and polydopamine nanoparticle composite hydrogels, as well as their applications of tissue adhesives, hemostasis, antimicrobials for wound closure and tissue regeneration. The challenges as well as prospects for future development of polyphenol-based tissue adhesives, sealants, hemostatic agents are also summarized and discussed, which is helpful to promote the next generation of tissue adhesives for biomedical applications.
- polyphenol,
- hydrogel,
- bio-adhesive,
- hemostasis,
- tissue healing
1. [1]
  Zhu, W.; Chuah, Y. J.; Wang, D. A. Acta Biomater. 2018, 74, 1. doi: 10.1016/j.actbio.2018.04.034
2. [2]
  Duarte, A. P.; Coelho, J. F.; Bordado, J. C.; Cidade, M. T.; Gil, M. H. Prog. Polym. Sci. 2012, 37, 1031. doi: 10.1016/j.progpolymsci.2011.12.003
3. [3]
  Bré, L. P.; Zheng, Y.; Pêgo, A. P.; Wang, W. Biomater. Sci. 2013, 1, 239. doi: 10.1039/C2BM00121G
4. [4]
  Liu, Z.; Meyers, M. A.; Zhang, Z.; Ritchie, R. O. Prog. Mater. Sci. 2017, 88, 467. doi: 10.1016/j.pmatsci.2017.04.013
5. [5]
  Lee, H.; Dellatore, S. M.; Miller, W. M.; Messersmith, P. B. Science 2007, 318, 426. doi: 10.1126/science.1147241
6. [6]
  Harrington, M. J.; Masic, A.; Holten-Andersen, N.; Waite, J. H.; Fratzl, P. Science 2010, 328, 216. doi: 10.1126/science.1181044
7. [7]
  Maier, G. P.; Rapp, M. V.; Waite, J. H.; Israelachvili, J. N.; Butler, A. Science 2015, 348, 628. doi: 10.1126/science.348.6235.628
8. [8]
  Rahim, M. A.; Kristufek, S. L.; Pan, S.; Richardson, J. J.; Caruso, F. Angew. Chem., Int. Ed. 2019, 58, 1904. doi: 10.1002/anie.201807804
9. [9]
  Liu, Y.; Ai, K.; Lu, L. Chem. Rev. 2014, 114, 5057. doi: 10.1021/cr400407a
10. [10]
  Lee, H.; Lee, B. P.; Messersmith, P. B. Nature 2007, 448, 338. doi: 10.1038/nature05968
11. [11]
  Lee, H. D., S.; Miller, W.; Messersmith, P. Science 2011, 318, 5.
12. [12]
  Dai, Q.; Geng, H.; Yu, Q.; Hao, J.; Cui, J. Theranostics 2019, 9, 3170. doi: 10.7150/thno.31847
13. [13]
  Patil, N.; Jérôme, C.; Detrembleur, C. Prog. Polym. Sci. 2018, 82, 34. doi: 10.1016/j.progpolymsci.2018.04.002
14. [14]
  Ejima, H. R., J.; Liang, K.; Best, J.; Koeverden, M.; Such, G.; Cui, J.; Caruso, F. Science 2013, 341, 5.
15. [15]
  Faure, E.; Falentin-Daudré, C.; Jérôme, C.; Lyskawa, J.; Fournier, D.; Woisel, P.; Detrembleur, C. Prog. Polym. Sci. 2013, 38, 236. doi: 10.1016/j.progpolymsci.2012.06.004
16. [16]
  Shukla, A.; Fang, J. C.; Puranam, S.; Jensen, F. R.; Hammond, P. T. Adv. Mater. 2012, 24, 492. doi: 10.1002/adma.201103794
17. [17]
  Chen, J.; Cheng, W.; Chen, S.; Xu, W.; Lin, J.; Liu, H.; Chen, Q. Nanoscale 2018, 10, 22818. doi: 10.1039/C8NR05882B
18. [18]
  Gopalakrishnan, L.; Ramana, L. N.; Sethuraman, S.; Krishnan, U. M. Carbohyd. Polym. 2014, 111, 215. doi: 10.1016/j.carbpol.2014.03.093
19. [19]
  Scalbert, A. Phytochemistry 1991, 30, 3875. doi: 10.1016/0031-9422(91)83426-L
20. [20]
  Choi, Y. S.; Kang, H.; Kim, D. G.; Cha, S. H.; Lee, J. C. ACS Appl. Mater. Interfaces 2014, 6, 21297. doi: 10.1021/am506263s
21. [21]
  Qi, C.; Fu, L.-H.; Xu, H.; Wang, T.-F.; Lin, J.; Huang, P. Sci. China Chem. 2019, 62, 162. doi: 10.1007/s11426-018-9392-6
22. [22]
  Wang, X.; Sheng, J.; Yang, M. Chinese Chem. Lett. 2019, 30, 533. doi: 10.1016/j.cclet.2018.10.010
23. [23]
  Ghobril, C.; Grinstaff, M. W. Chem. Soc. Rev. 2015, 44, 1820. doi: 10.1039/C4CS00332B
24. [24]
  Zhang, K.; Zhang, F.; Song, Y.; Fan, J. B.; Wang, S. Chin. J. Chem. 2017, 35, 811. doi: 10.1002/cjoc.201600778
25. [25]
  Zhang, H.; Zhao, T.; Newland, B.; Liu, W.; Wang, W.; Wang, W. Prog. Polym. Sci. 2018, 78, 47. doi: 10.1016/j.progpolymsci.2017.09.002
26. [26]
  Han, L.; Yan, L.; Wang, K.; Fang, L.; Zhang, H.; Tang, Y.; Ding, Y.; Weng, L. T.; Xu, J.; Weng, J.; Liu, Y.; Ren, F.; Lu, X. NPG Asia Mater. 2017, 9, e372. doi: 10.1038/am.2017.33
27. [27]
  Huang, K.; Lee, B. P.; Ingram, D. R.; Messersmith, P. B. Biomacromolecules 2002, 3, 397. doi: 10.1021/bm015650p
28. [28]
  Krogsgaard, M.; Andersen, A.; Birkedal, H. Chem. Commun. 2014, 50, 13278. doi: 10.1039/C4CC05293E
29. [29]
  North, M. A.; Del, Grosso, C. A.; Wilker, J. J. ACS Appl. Mater. Interfaces 2017, 9, 7866. doi: 10.1021/acsami.7b00270
30. [30]
  Mu, Y.; Wu, X.; Pei, D.; Wu, Z.; Zhang, C.; Zhou, D.; Wan, X. ACS Biomater. Sci. Eng. 2017, 3, 3133. doi: 10.1021/acsbiomaterials.7b00673
31. [31]
  Lee, B. P.; Dalsin, J. L.; Messersmith, P. B. Biomacromolecules 2002, 3, 1038. doi: 10.1021/bm025546n
32. [32]
  Burke, S. A.; Ritter-Jones, M.; Lee, B. P.; Messersmith, P. B. Biomed. Mater. 2007, 2, 203. doi: 10.1088/1748-6041/2/4/001
33. [33]
  Bilic, G.; Brubaker, C.; Messersmith, P. B.; Mallik, A. S.; Quinn, T. M.; Haller, C.; Done, E.; Gucciardo, L.; Zeisberger, S. M.; Zimmermann, R.; Deprest, J.; Zisch, A. H. Am. J. Obstet. Gynecol. 2010, 202, 85.
34. [34]
  Brubaker, C. E.; Kissler, H.; Wang, L. J.; Kaufman, D. B.; Messersmith, P. B. Biomaterials 2010, 31, 420. doi: 10.1016/j.biomaterials.2009.09.062
35. [35]
  Mehdizadeh, M.; Weng, H.; Gyawali, D.; Tang, L.; Yang, J. Biomaterials 2012, 33, 7972.. doi: 10.1016/j.biomaterials.2012.07.055
36. [36]
  Brubaker, C. E.; Messersmith, P. B. Biomacromolecules 2011, 12, 4326. doi: 10.1021/bm201261d
37. [37]
  Mou, C.; Ali, F.; Malaviya, A.; Bettinger, C. J. J. Mater. Chem. B 2019, 7, 1690. doi: 10.1039/C8TB02854K
38. [38]
  Holten-Andersen, N.; Harrington, M. J.; Birkedal, H.; Lee, B. P.; Messersmith, P. B.; Lee, K. Y.; Waite, J. H. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 2651. doi: 10.1073/pnas.1015862108
39. [39]
  He, L.; Fullenkamp, D. E.; Rivera, J. G.; Messersmith, P. B. Chem. Commun. 2011, 47, 7497. doi: 10.1039/c1cc11928a
40. [40]
  Guo, J.; Sun, W.; Kim, J. P.; Lu, X.; Li, Q.; Lin, M.; Mrowczynski, O.; Rizk, E. B.; Cheng, J.; Qian, G.; Yang, J. Acta Biomater. 2018, 72, 35. doi: 10.1016/j.actbio.2018.03.008
41. [41]
  Li, N.; Yang, X.; Liu, W.; Xi, G.; Wang, M.; Liang, B.; Ma, Z.; Feng, Y.; Chen, H.; Shi, C. Macromol. Biosci. 2018, 18, e1800209. doi: 10.1002/mabi.201800209
42. [42]
  Wang, C.; Zhou, H.; Niu, H.; Ma, X.; Yuan, Y.; Hong, H.; Liu, C. Biomater. Sci. 2018, 6, 3318. doi: 10.1039/C8BM00837J
43. [43]
  Erel-Unal, I.; Sukhishvili, S. A. Macromolecules 2008, 41, 3962. doi: 10.1021/ma800186q
44. [44]
  Kim, K.; Shin, M.; Koh, M. Y.; Ryu, J. H.; Lee, M. S.; Hong, S.; Lee, H. Adv. Funct. Mater. 2015, 25, 2402. doi: 10.1002/adfm.201500034
45. [45]
  Xu, R.; Ma, S.; Lin, P.; Yu, B.; Zhou, F.; Liu, W. ACS Appl. Mater. Interfaces 2018, 10, 7593. doi: 10.1021/acsami.7b04290
46. [46]
  Nam, H. G.; Nam, M. G.; Yoo, P. J.; Kim, J. Soft Matter 2019, 15, 785. doi: 10.1039/C8SM02144A
47. [47]
  Zhou, L.; Fan, L.; Yi, X.; Zhou, Z.; Liu, C.; Fu, R.; Dai, C.; Wang, Z.; Chen, X.; Yu, P.; Chen, D.; Tan, G.; Wang, Q.; Ning, C. ACS Nano 2018, 12, 10957. doi: 10.1021/acsnano.8b04609
48. [48]
  Fan, H.; Wang, L.; Feng, X.; Bu, Y.; Wu, D.; Jin, Z. Macromolecules 2017, 50, 666. doi: 10.1021/acs.macromol.6b02106
49. [49]
  Fan, H.; Wang, J.; Zhang, Q.; Jin, Z. ACS Omega 2017, 2, 6668. doi: 10.1021/acsomega.7b01067
50. [50]
  Zheng, L. Y.; Shi, J. M.; Chi, Y. H. Macromol. Chem. Phys. 2018, 219, 1800234. doi: 10.1002/macp.201800234
51. [51]
  Sahiner, N.; Sagbas, S.; Sahiner, M.; Silan, C.; Aktas, N.; Turk, M. Int. J. Biol. Macromol. 2016, 82, 150. doi: 10.1016/j.ijbiomac.2015.10.057
52. [52]
  Sahiner, N.; Sagbas, S.; Aktas, N. Polym. Degrad. Stabil. 2016, 129, 96. doi: 10.1016/j.polymdegradstab.2016.04.010
53. [53]
  Hong, S. H.; Shin, M.; Lee, J.; Ryu, J. H.; Lee, S.; Yang, J. W.; Kim, W. D.; Lee, H. Adv. Healthcare Mater. 2016, 5, 75. doi: 10.1002/adhm.201400833
54. [54]
  Shao, C.; Meng, L.; Wang, M.; Cui, C.; Wang, B.; Han, C. R.; Xu, F.; Yang, J. ACS Appl. Mater. Interfaces 2019, 11, 5885. doi: 10.1021/acsami.8b21588
55. [55]
  Ryu, J. H.; Hong, S.; Lee, H. Acta Biomater. 2015, 27, 101. doi: 10.1016/j.actbio.2015.08.043
56. [56]
  Zhu, W.; Iqbal, J.; Wang. D. A. J. Mater. Chem. B 2019, 7, 1741. doi: 10.1039/C8TB01990H
57. [57]
  Levengood, S. L.; Zhang, M. J. Mater. Chem. B 2014, 2, 3161. doi: 10.1039/c4tb00027g
58. [58]
  Ryu, J. H.; Lee, Y.; Kong, W. H.; Kim, T. G.; Park, T. G.; Lee, H. Biomacromolecules 2011, 12, 2653. doi: 10.1021/bm200464x
59. [59]
  Shin, M.; Park, S. G.; Oh, B. C.; Kim, K.; Jo, S.; Lee, M. S.; Oh, S. S.; Hong, S. H.; Shin, E. C.; Kim, K. S.; Kang, S. W.; Lee, H. Nat. Mater. 2017, 16, 147. doi: 10.1038/nmat4758
60. [60]
  Shin, M.; Ryu, J. H.; Kim, K.; Kim, M. J.; Jo, S.; Lee, M. S.; Lee, D. Y.; Lee, H. ACS Biomater. Sci. Eng. 2018, 4, 2314. doi: 10.1021/acsbiomaterials.8b00451
61. [61]
  Zhu, W.; Peck, Y.; Iqbal, J.; Wang, D. A. Biomaterials 2017, 147, 99. doi: 10.1016/j.biomaterials.2017.09.016
62. [62]
  Natarajan, V.; Krithica, N.; Madhan, B.; Sehgal, P. K. J. Biomed. Mater. Res. B 2013, 101, 560.
63. [63]
  Fan, C.; Fu, J.; Zhu, W.; Wang, D. A. Acta Biomater. 2016, 33, 51. doi: 10.1016/j.actbio.2016.02.003
64. [64]
  Lu, D.; Wang, H.; Li, T. E.; Li, Y.; Wang, X.; Niu, P.; Guo, H.; Sun, S.; Wang, X.; Guan, X.; Ma, H.; Lei, Z. Chem. Mater. 2017, 29, 5493. doi: 10.1021/acs.chemmater.7b00255
65. [65]
  Wang, R.; Li, J.; Chen, W.; Xu, T.; Yun, S.; Xu, Z.; Xu, Z.; Sato, T.; Chi, B.; Xu, H. Adv. Funct. Mater. 2017, 27, 1604894. doi: 10.1002/adfm.201604894
66. [66]
  Han, X.; Meng, G.; Wang, Q.; Cui, L.; Wang, H.; Wu, J.; Liu, Z.; Guo, X. J. Biomater. Appl. 2019, 33, 915. doi: 10.1177/0885328218810552
67. [67]
  Shin, M.; Ryu, J. H.; Park, J. P.; Kim, K.; Yang, J. W.; Lee, H. Adv. Funct. Mater. 2015, 25, 1270. doi: 10.1002/adfm.201403992
68. [68]
  Schexnailder, P.; Schmidt, G. Colloid Polym. Sci. 2008, 287, 1.
69. [69]
  Thoniyot, P.; Tan, M. J.; Karim, A. A.; Young, D. J.; Loh, X. J. Adv. Sci. 2015, 2, 1400010. doi: 10.1002/advs.201400010
70. [70]
  Rose, S.; Prevoteau, A.; Elziere, P.; Hourdet, D.; Marcellan, A.; Leibler, L. Nature 2014, 505, 382. doi: 10.1038/nature12806
71. [71]
  Li, L.; Smitthipong, W.; Zeng, H. Polym. Chem. 2015, 6, 353. doi: 10.1039/C4PY01415D
72. [72]
  Han, L.; Lu, X.; Liu, K.; Wang, K.; Fang, L.; Weng, L. T.; Zhang, H.; Tang, Y.; Ren, F.; Zhao, C.; Sun, G.; Liang, R.; Li, Z. ACS Nano 2017, 11, 2561. doi: 10.1021/acsnano.6b05318
73. [73]
  Ding, X.; Vegesna, G. K.; Meng, H.; Lee, B. P.; Winter, A. Macromol. Chem. Phys. 2015, 216, 1109. doi: 10.1002/macp.201500010
74. [74]
  Liu, Y.; Meng, H.; Qian, Z.; Fan, N.; Choi, W.; Zhao, F.; Lee, B. P. Angew. Chem. Int. Ed. 2017, 56, 4224. doi: 10.1002/anie.201700628
75. [75]
  Lynge, M. E.; Schattling, P.; Stadler, B. Nanomedicine 2015, 10, 2725. doi: 10.2217/nnm.15.89
76. [76]
  Wang, X.; Wang, C.; Wang, X.; Wang, Y.; Zhang, Q.; Cheng, Y. Chem. Mater. 2017, 29, 1370. doi: 10.1021/acs.chemmater.6b05192
77. [77]
  Wang, C.; Zhang, Q.; Wang, X.; Chang, H.; Zhang, S.; Tang, Y.; Xu, J.; Qi, R.; Cheng, Y. Angew. Chem. Int. Ed. 2017, 56, 6767. doi: 10.1002/anie.201700968
78. [78]
  Hu, W.; Lu, S.; Zhang, Z.; Zhu, L.; Wen, Y.; Zhang, T.; Ji, Z. Biomater. Sci. 2019, 7, 1323. doi: 10.1039/C8BM01198B
79. [79]
  Han, L.; Zhang, Y.; Lu, X.; Wang, K.; Wang, Z.; Zhang, H. ACS Appl. Mater. Interfaces 2016, 8, 29088. doi: 10.1021/acsami.6b11043
80. [80]
  Zhu, S.; Gu, Z.; Xiong, S.; An, Y.; Liu, Y.; Yin, T.; You, J.; Hu, Y. RSC Adv. 2016, 6, 66180. doi: 10.1039/C6RA12306F
81. [81]
  Tang, P.; Han, L.; Li, P.; Jia, Z.; Wang, K.; Zhang, H.; Tan, H.; Guo, T.; Lu, X. ACS Appl. Mater. Interfaces 2019, 11, 7703. doi: 10.1021/acsami.8b18931
82. [82]
  Gao, G.; Jiang, Y. W.; Jia, H. R.; Wu, F. G. Biomaterials 2019, 188, 83. doi: 10.1016/j.biomaterials.2018.09.045
83. [83]
  Jing, X.; Mi, H. Y.; Napiwocki, B. N.; Peng, X. F.; Turng, L. S. Carbon 2017, 125, 557. doi: 10.1016/j.carbon.2017.09.071
84. [84]
  Han, L.; Lu, X.; Wang, M.; Gan, D.; Deng, W.; Wang, K.; Fang, L.; Liu, K.; Chan, C. W.; Tang, Y.; Weng, L. T.; Yuan, H. Small 2017, 13, 1601916. doi: 10.1002/smll.201601916
85. [85]
  Chen, Q.; Wang, C.; Zhang, X.; Chen, G.; Hu, Q.; Li, H.; Wang, J.; Wen, D.; Zhang, Y.; Lu, Y.; Yang, G.; Jiang, C.; Wang, J.; Dotti, G.; Gu, Z. Nat. Nanotechnol. 2019, 14, 89. doi: 10.1038/s41565-018-0319-4
1. [1]
  Qiang Zhou , Pingping Zhu , Wei Shao , Wanqun Hu , Xuan Lei , Haiyang Yang . Innovative Experimental Teaching Design for 3D Printing High-Strength Hydrogel Experiments. University Chemistry, 2024, 39(6): 264-270. doi: 10.3866/PKU.DXHX202310064
2. [2]
  Qingyang Cui , Feng Yu , Zirun Wang , Bangkun Jin , Wanqun Hu , Wan Li . From Jelly to Soft Matter: Preparation and Properties-Exploring of Different Kinds of Hydrogels. University Chemistry, 2024, 39(9): 338-348. doi: 10.3866/PKU.DXHX202309046
3. [3]
  Yuena Yang , Xufang Hu , Yushan Liu , Yaya Kuang , Jian Ling , Qiue Cao , Chuanhua Zhou . The Realm of Smart Hydrogels. University Chemistry, 2024, 39(5): 172-183. doi: 10.3866/PKU.DXHX202310125
4. [4]
  Tengjiao Wang , Tian Cheng , Rongjun Liu , Zeyi Wang , Yuxuan Qiao , An Wang , Peng Li . Conductive Hydrogel-based Flexible Electronic System: Innovative Experimental Design in Flexible Electronics. University Chemistry, 2024, 39(4): 286-295. doi: 10.3866/PKU.DXHX202309094
5. [5]
  Hongyun Liu , Jiarun Li , Xinyi Li , Zhe Liu , Jiaxuan Li , Cong Xiao . Course Ideological and Political Design of a Comprehensive Chemistry Experiment: Constructing a Visual Molecular Logic System Based on Intelligent Hydrogel Film Electrodes. University Chemistry, 2024, 39(2): 227-233. doi: 10.3866/PKU.DXHX202309070
6. [6]
  Lijuan Liu , Xionglei Wang . Preparation of Hydrogels from Waste Thermosetting Unsaturated Polyester Resin by Controllable Catalytic Degradation: A Comprehensive Chemical Experiment. University Chemistry, 2024, 39(11): 313-318. doi: 10.12461/PKU.DXHX202403060
7. [7]
  Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb₂ complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357
8. [8]
  Yongqing Kuang , Jie Liu , Jianjun Feng , Wen Yang , Shuanglian Cai , Ling Shi . Experimental Design for the Two-Step Synthesis of Paracetamol from 4-Hydroxyacetophenone. University Chemistry, 2024, 39(8): 331-337. doi: 10.12461/PKU.DXHX202403012
9. [9]
  Xiyuan Su , Zhenlin Hu , Ye Fan , Xianyuan Liu , Xianyong Lu . Change as You Want: Multi-Responsive Superhydrophobic Intelligent Actuation Material. University Chemistry, 2024, 39(5): 228-237. doi: 10.3866/PKU.DXHX202311059
10. [10]
  Zongpei Zhang , Yanyang Li , Yanan Si , Kai Li , Shuangquan Zang . Developing a Chemistry Experiment Center Employing a Multifaceted Approach to Serve High-Quality Laboratory Education. University Chemistry, 2024, 39(7): 13-19. doi: 10.12461/PKU.DXHX202404041
11. [11]
  Ruilin Han , Xiaoqi Yan . Comparison of Multiple Function Methods for Fitting Surface Tension and Concentration Curves. University Chemistry, 2024, 39(7): 381-385. doi: 10.3866/PKU.DXHX202311023
12. [12]
  Lu XU , Chengyu ZHANG , Wenjuan JI , Haiying YANG , Yunlong FU . Zinc metal-organic framework with high-density free carboxyl oxygen functionalized pore walls for targeted electrochemical sensing of paracetamol. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 907-918. doi: 10.11862/CJIC.20230431
13. [13]
  Liang TANG , Jingfei NI , Kang XIAO , Xiangmei LIU . Synthesis and X-ray imaging application of lanthanide-organic complex-based scintillators. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1892-1902. doi: 10.11862/CJIC.20240139
14. [14]
  Kai CHEN , Fengshun WU , Shun XIAO , Jinbao ZHANG , Lihua ZHU . PtRu/nitrogen-doped carbon for electrocatalytic methanol oxidation and hydrogen evolution by water electrolysis. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1357-1367. doi: 10.11862/CJIC.20230350
15. [15]
  Dong-Bing Cheng , Junxin Duan , Haiyu Gao . Experimental Teaching Design on Chitosan Extraction and Preparation of Antibacterial Gel. University Chemistry, 2024, 39(2): 330-339. doi: 10.3866/PKU.DXHX202308053
16. [16]
  Shule Liu . Application of SPC/E Water Model in Molecular Dynamics Teaching Experiments. University Chemistry, 2024, 39(4): 338-342. doi: 10.3866/PKU.DXHX202310029
17. [17]
  Ji-Quan Liu , Huilin Guo , Ying Yang , Xiaohui Guo . Calculation and Discussion of Electrode Potentials in Redox Reactions of Water. University Chemistry, 2024, 39(8): 351-358. doi: 10.3866/PKU.DXHX202401031
18. [18]
  Haoxiang Zhang , Zhihan Zhao , Yongchen Jin , Zhiqiang Niu , Jinlei Tian . Synthesis of an Efficient Absorbent Gel: A Recommended Comprehensive Chemistry Experiment. University Chemistry, 2024, 39(11): 251-258. doi: 10.12461/PKU.DXHX202401084
19. [19]
  Conghao Shi , Ranran Wang , Juli Jiang , Leyong Wang . The Illustration on Stereoisomers of Macrocycles Containing Multiple Chiral Centers via Tröger Base-based Macrocycles. University Chemistry, 2024, 39(7): 394-397. doi: 10.3866/PKU.DXHX202311034
20. [20]
  Shengbiao Zheng , Liang Li , Nini Zhang , Ruimin Bao , Ruizhang Hu , Jing Tang . Metal-Organic Framework-Derived Materials Modified Electrode for Electrochemical Sensing of Tert-Butylhydroquinone: A Recommended Comprehensive Chemistry Experiment for Translating Research Results. University Chemistry, 2024, 39(7): 345-353. doi: 10.3866/PKU.DXHX202310096

Get Citation

PDF

XML

Metrics

PDF Downloads(130)
Abstract views(3463)
HTML views(1313)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142