Citation: Jin Xin, Wang XiaoYing. Progress in Analysis and Detection of Salivary Tumor Biomarkers Associated with Oral Cancer[J]. Acta Chimica Sinica, ;2019, 77(4): 340-350. doi: 10.6023/A18100414 shu

Progress in Analysis and Detection of Salivary Tumor Biomarkers Associated with Oral Cancer

Jin Xin ,
Wang XiaoYing ^,

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China

Corresponding author: Wang XiaoYing, wxy@seu.edu.cn
Received Date: 7 October 2018
Available Online: 3 April 2018
Fund Project: the National Natural Science Foundation of China 81600179Project supported by the National Natural Science Foundation of China (Nos. 81600179, 81302472) and "Blue Project" funded by universities in Jiangsuthe National Natural Science Foundation of China 81302472

Figures(9)

Oral cancer is head and neck cancer, and cancer tissue is located in the oral cavity. The non-invasive early diagnosis is an effective method to reduce the death of the disease. The oral cancer-related substances are first released into the saliva, which is convenient, safe and non-invasive, and is the first choice for screening and early diagnosis of oral cancer. In this paper, the specific types and the commonly used detection methods of the salivary tumor biomarkers at home and abroad were summarized and compared. Specifically, the latest application of new electrochemical biosensor in the detection of the salivary tumor biomarkers associated with oral cancer was mainly described. Futhermore, the summary of its future directions and the potential applications was proposed, which provided reference for the further research and application of the salivary tumor biomarkers in oral cancer.
- oral cancer,
- saliva,
- tumor biomarker,
- detection technology,
- electrochemical biosensor
1. [1]
  Radhika, T.; Jeddy, N.; Nithya, S.; Muthumeenakshi, R. M. Jobcr. 2016, 6, S51.
2. [2]
  Kaczor-Urbanowicz, K. E.; Martin Carreras-Presas, C.; Kaczor, T.; Tu, M.; Wei, F.; Garcia-Godoy, F.; Wong, D. T. J. Cell. Mol. Med. 2017, 21(4), 640. doi: 10.1111/jcmm.2017.21.issue-4
3. [3]
  Sannam Khan, R.; Khurshid, Z.; Akhbar, S.; Faraz Moin, S. Proteomes. 2016, 4(4), 41. doi: 10.3390/proteomes4040041
4. [4]
  Saxena, S.; Sankhla, B.; Sundaragiri, K. S.; Bhargava, A. Adv. Biomed. Res. 2017, 6, 90. doi: 10.4103/2277-9175.211801
5. [5]
  Aps, J. K.; Martens, L. C. Forensic Sci. Int. 2005, 150(2-3), 119. doi: 10.1016/j.forsciint.2004.10.026
6. [6]
  Jensdottir, T.; Nauntofte, B.; Buchwald, C.; Bardow, A. Caries Res. 2005, 39(6), 468. doi: 10.1159/000088181
7. [7]
  Kurgan, S.; Kantarci, A. Periodontol 2000 2018, 76(1), 51. doi: 10.1111/prd.12146
8. [8]
  Prasad, S.; Tyagi, A. K.; Aggarwal, B. B. Exp. Biol. Med. 2016, 241(8), 783. doi: 10.1177/1535370216638770
9. [9]
  Yang, S. F.; Huang, H. D.; Fan, W. L.; Jong, Y. J.; Chen, M. K.; Huang, C. N.; Chuang, C. Y.; Kuo, Y. L.; Chung, W. H.; Su, S. C. Oral Oncol. 2018, 77, 1. doi: 10.1016/j.oraloncology.2017.12.005
10. [10]
  Arantes, L.; De Carvalho, A. C.; Melendez, M. E.; Lopes Carvalho, A. Expert Rev. Mol. Diagn. 2018, 18(1), 85. doi: 10.1080/14737159.2017.1404906
11. [11]
  Zhang, Y.; Sun, J.; Lin, C.-C.; Abemayor, E.; Wang, M. B.; Wong, D. T. W. Periodontol 2000, 2016, 70(1), 38. doi: 10.1111/prd.12099
12. [12]
  Rosas, S. L. B.; Koch, W.; Carvalho, M. D. D.; Wu, L.; Califano, J.; Westra, W.; Jen, J.; Sidransky, D. Cancer Res. 2001, 61(3), 939.
13. [13]
  Zhang, L.; Rosin, M. P. J. Oral Pathol. Med. 2001, 30(9), 513. doi: 10.1034/j.1600-0714.2001.300901.x
14. [14]
  Rosin, M. P.; Cheng, X.; Poh, C.; Lam, W. L.; Huang, Y. Q.; Lovas, J.; Berean, K.; Epstein, J. B.; Priddy, R.; Le, N. D.; Zhang, L. W. Clin. Cancer Res. 2000, 6(2), 357.
15. [15]
  Wang, Y.; Springer, S.; Mulvey, C. L.; Silliman, N.; Schaefer, J.; Sausen, M.; James, N.; Rettig, E. M.; Guo, T.; Pickering, C. R.; Bishop, J. A.; Chung, C. H.; Califano, J. A.; Eisele, D. W.; Fakhry, C.; Gourin, C. G.; Ha, P. K.; Kang, H.; Kiess, A.; Koch, W. M.; Myers, J. N.; Quon, H.; Richmon, J. D.; Sidransky, D.; Tufano, R. P.; Westra, W. H.; Bettegowda, C.; Diaz, L. A., Jr.; Papadopoulos, N.; Kinzler, K. W.; Vogelstein, B.; Agrawal, N. Sci. Transl. Med. 2015, 7(293), 293ra104.
16. [16]
  Vielba, R.; Bilbao, J.; Ispizua, A.; Zabalza, I.; Alfaro, J.; Rezola, R.; Moreno, E.; Elorriaga, J.; Alonso, I.; Baroja, A.; de la Hoz, C. Laryngoscope, 2003, 113(1), 167. doi: 10.1097/00005537-200301000-00031
17. [17]
  Li, Y.; St John, M. A. R.; Zhou, X. F.; Kim, Y.; Sinha, U.; Jordan, R. C. K.; Eisele, D.; Abemayor, E.; Elashoff, D.; Park, N. H.; Wong, D. T. Clin. Cancer Res. 2004, 10(24), 8442. doi: 10.1158/1078-0432.CCR-04-1167
18. [18]
  Park, N. J.; Zhou, H.; Elashoff, D.; Henson, B. S.; Kastratovic, D. A.; Abemayor, E.; Wong, D. T. Clin. Cancer Res. 2009, 15(17), 5473. doi: 10.1158/1078-0432.CCR-09-0736
19. [19]
  St John, M. A. R.; Li, Y.; Zhou, X. F.; Denny, P.; Ho, C. M.; Montemagno, C.; Shi, W. Y.; Qi, F. X.; Wu, B.; Sinha, U.; Jordan, R.; Wolinsky, L.; Park, N. H.; Liu, H. H.; Abemayor, E.; Wong, D. T. W. Arch. Otolaryngol. 2004, 130(8), 929. doi: 10.1001/archotol.130.8.929
20. [20]
  Nagler, R.; Bahar, G.; Shpitzer, T.; Feinmesser, R. Clin. Cancer Res. 2006, 12(13), 3979. doi: 10.1158/1078-0432.CCR-05-2412
21. [21]
  Wang, Y.; Gao, X.; Wei, F.; Zhang, X.; Yu, J.; Zhao, H.; Sun, Q.; Yan, F.; Yan, C.; Li, H.; Ren, X. Tumor Biol. 2015, 36(2), 1029. doi: 10.1007/s13277-014-2710-6
22. [22]
  Shintani, S.; Hamakawa, H.; Ueyama, Y.; Hatori, M.; Toyoshima, T. Int. J. Oral Surg. 2010, 39(1), 68. doi: 10.1016/j.ijom.2009.10.001
23. [23]
  Franzmann, E. J.; Reategui, E. P.; Pereira, L. H.; Pedroso, F.; Joseph, D.; Allen, G. O.; Hamilton, K.; Reis, I.; Duncan, R.; Goodwin, W. J.; Hu, J. J.; Lokeshwar, V. B. Head & Neck, 2012, 34(5), 687.
24. [24]
  Awasthi, N. Indian J. Pathol. Bacteriol. 2017, 60(4), 464.
25. [25]
  Zhang, X. Y.; Huang, Z. Q.; Hu, Y. J.; Liu, L. J. Oral Pathol. Med. 2016, 45(10), 740. doi: 10.1111/jop.2016.45.issue-10
26. [26]
  Kang, M.-S.; Oh, J.-S.; Kim, H.-J.; Kim, H.-N.; Lee, I.-K.; Choi, H.-R.; Kim, O.-J.; Ko, Y.-J.; Lim, W.-B.; Park, H.-J.; Yu, M.-G.; Chung, K.-Y.; Kim, S.-M.; Lim, H.-S. J. Bacteriol. Virol. 2009, 39(4), 277. doi: 10.4167/jbv.2009.39.4.277
27. [27]
  Sugimoto, M.; Wong, D. T.; Hirayama, A.; Soga, T.; Tomita, M. Metabolomics, 2010, 6(1), 78. doi: 10.1007/s11306-009-0178-y
28. [28]
  Peres, J. C.; Rouquette, J. L.; Miocevic, O.; Warner, M. C.; Slowey, P. D.; Shirtcliff, E. A. Clin. Ther. 2015, 37(3), 515. doi: 10.1016/j.clinthera.2015.02.015
29. [29]
  Hasnis, E.; Reznick, A. Z.; Pollack, S.; Klein, Y.; Nagler, R. M. Int. J. Biochem. Cell Biol. 2004, 36(5), 826. doi: 10.1016/j.biocel.2003.09.003
30. [30]
  Chiappin, S.; Antonelli, G.; Gatti, R.; De Palo, E. F. Clin. Chim. Acta.2007, 383(1-2), 30. doi: 10.1016/j.cca.2007.04.011
31. [31]
  Granger, D. A.; Kivlighan, K. T.; Fortunato, C.; Harmon, A. G.; Hibel, L. C.; Schwartz, E. B.; Whembolua, G.-L. Physiol. Behav. 2007, 92(4), 583. doi: 10.1016/j.physbeh.2007.05.004
32. [32]
  Gaykalova, D. A.; Vatapalli, R.; Wei, Y.; Tsai, H. L.; Wang, H.; Zhang, C.; Hennessey, P. T.; Guo, T.; Tan, M.; Li, R.; Ahn, J.; Khan, Z.; Westra, W. H.; Bishop, J. A.; Zaboli, D.; Koch, W. M.; Khan, T.; Ochs, M. F.; Califano, J. A. PLoS One, 2015, 10(11), e0142148. doi: 10.1371/journal.pone.0142148
33. [33]
  Schussel, J.; Zhou, X. C.; Zhang, Z.; Pattani, K.; Bermudez, F.; Jean-Charles, G.; McCaffrey, T.; Padhya, T.; Phelan, J.; Spivakovsky, S.; Brait, M.; Li, R.; Bowne, H. Y.; Goldberg, J. D.; Rolnitzky, L.; Robbins, M.; Kerr, A. R.; Sirois, D.; Califano, J. A. Clin. Cancer Res. 2013, 19(12), 3268. doi: 10.1158/1078-0432.CCR-12-3496
34. [34]
  Hung, K. F.; Liu, C. J.; Chiu, P. C.; Lin, J. S.; Chang, K. W.; Shih, W. Y.; Kao, S. Y.; Tu, H. F. Oral Oncol. 2016, 53, 42. doi: 10.1016/j.oraloncology.2015.11.017
35. [35]
  Xie, Z.; Chen, G.; Zhang, X.; Li, D.; Huang, J.; Yang, C.; Zhang, P.; Qin, Y.; Duan, Y.; Gong, B.; Li, Z. PLoS One 2013, 8(4), e57502. doi: 10.1371/journal.pone.0057502
36. [36]
  Katakura, A.; Kamiyama, I.; Takano, N.; Shibahara, T.; Muramatsu, T.; Ishihara, K.; Takagi, R.; Shouno, T. The Bulletin of Tokyo Dental College, 2007, 48(4), 199. doi: 10.2209/tdcpublication.48.199
37. [37]
  Franzmann, E. J.; Reategui, E. P.; Pedroso, F.; Pernas, F. G.; Karakullukcu, B. M.; Carraway, K. L.; Hamilton, K.; Singal, R.; Goodwin, W. J. Cancer Epidemiol., Biomarkers Prev. 2007, 16(7), 1348. doi: 10.1158/1055-9965.EPI-06-0011
38. [38]
  Hu, S.; Arellano, M.; Boontheung, P.; Wang, J.; Zhou, H.; Jiang, J.; Elashoff, D.; Wei, R.; Loo, J. A.; Wong, D. T. Clin. Cancer Res. 2008, 14(19), 6246. doi: 10.1158/1078-0432.CCR-07-5037
39. [39]
  Dowling, P.; Wormald, R.; Meleady, P.; Henry, M.; Curran, A.; Clynes, M. J. Proteomics 2008, 71(2), 168.
40. [40]
  Jou, Y. J.; Lin, C. D.; Lai, C. H.; Tang, C. H.; Huang, S. H.; Tsai, M. H.; Chen, S. Y.; Kao, J. Y.; Lin, C. W. Clin. Chim. Acta 2011, 412, 1357. doi: 10.1016/j.cca.2011.04.004
41. [41]
  Jessie, K.; Jayapalan, J. J.; Ong, K. C.; Abdul Rahim, Z. H.; Zain, R. M.; Wong, K. T.; Hashim, O. H. Electrophoresis, 2013, 34(17), 2495. doi: 10.1002/elps.201300107
42. [42]
  Hernández-Arteaga, A.; de Jesús Zermeño Nava, J.; Kolosovas-Machuca, E. S.; Velázquez-Salazar, J. J.; Vinogradova, E.; José-Yacamán, M.; Navarro-Contreras, H. R. Nano Res. 2017, 10(11), 3662. doi: 10.1007/s12274-017-1576-5
43. [43]
  Schapher, M.; Wendler, O.; Groeschl, M.; Schaefer, R.; Iro, H.; Zenk, J. Clin. Chem. 2009, 55(5), 914. doi: 10.1373/clinchem.2008.116939
44. [44]
  Shpitzer, T.; Hamzany, Y.; Bahar, G.; Feinmesser, R.; Savulescu, D.; Borovoi, I.; Gavish, M.; Nagler, R. M. Br. J. Cancer, 2009, 101(7), 1194. doi: 10.1038/sj.bjc.6605290
45. [45]
  Elashoff, D.; Zhou, H.; Reiss, J.; Wang, J.; Xiao, H.; Henson, B.; Hu, S.; Arellano, M.; Sinha, U.; Le, A.; Messadi, D.; Wang, M.; Nabili, V.; Lingen, M.; Morris, D.; Randolph, T.; Feng, Z.; Akin, D.; Kastratovic, D. A.; Chia, D.; Abemayor, E.; Wong, D. T. W. Cancer Epidemiol., Biomarkers Prev. 2012, 21(4), 664. doi: 10.1158/1055-9965.EPI-11-1093
46. [46]
  Nagler, R.; Bahar, G.; Shpitzer, T.; Feinmesser, R. Clin. Cancer Res. 2006, 12(13), 3979. doi: 10.1158/1078-0432.CCR-05-2412
47. [47]
  Ma, C. Y.; Zhang, C. P.; Zhong, L. P.; Pan, H. Y.; Chen, W. T.; Wang, L. Z.; Andrew, O. W.; Ji, T.; Han, W. Oncol. Rep. 2011, 26(4), 813.
48. [48]
  Sawant, S. S.; Zingde, S. M.; Vaidya, M. M. Oral Oncol. 2008, 44(8), 722. doi: 10.1016/j.oraloncology.2007.10.008
49. [49]
  Yang, Y.; Rhodus, N. L.; Ondrey, F. G.; Wuertz, B. R.; Chen, X.; Zhu, Y.; Griffin, T. J. PLoS One 2014, 9(4), e95389. doi: 10.1371/journal.pone.0095389
50. [50]
  de Jong, E. P.; Xie, H.; Onsongo, G.; Stone, M. D.; Chen, X.-B.; Kooren, J. A.; Refsland, E. W.; Griffin, R. J.; Ondrey, F. G.; Wu, B.; Le, C. T.; Rhodus, N. L.; Carlis, J. V.; Griffin, T. J. PLoS One 2010, 5(6), e11148. doi: 10.1371/journal.pone.0011148
51. [51]
  Mager, D. L.; Haffajee, A. D.; Devlin, P. M.; Norris, C. M.; Posner, M. R.; Goodson, J. M. J. Transl. Med. 2005, 3, 27. doi: 10.1186/1479-5876-3-27
52. [52]
  Wang, X.; Wang, Y.; Shan, Y.; Jiang, M.; Gong, M.; Jin, X.; Wang, X.; Cheng, J. Talanta 2018, 187, 179. doi: 10.1016/j.talanta.2018.05.033
53. [53]
  Wang, X.; Wang, Y.; Shan, Y.; Jiang, M.; Jin, X.; Gong, M.; Xu, J. J. Electroanal. Chem. 2018, 823, 368. doi: 10.1016/j.jelechem.2018.06.030
54. [54]
  Tan, Y.; Wei, X.; Zhao, M.; Qiu, B.; Guo, L.; Lin, Z.; Yang, H. H. Anal. Chem. 2015, 87(18), 9204. doi: 10.1021/acs.analchem.5b01470
55. [55]
  Wei, F.; Wang, J.; Liao, W.; Zimmermann, B. G.; Wong, D. T.; Ho, C. M. Nucleic Acids Res. 2008, 36(11), e65. doi: 10.1093/nar/gkn299
56. [56]
  Wei, F.; Liao, W.; Xu, Z.; Yang, Y.; Wong, D. T.; Ho, C. M. Small 2009, 5(15), 1784. doi: 10.1002/smll.v5:15
57. [57]
  Wang, Z.; Zhang, J.; Guo, Y.; Wu, X.; Yang, W.; Xu, L.; Chen, J.; Fu, F. Biosens. Bioelectron. 2013, 45, 108. doi: 10.1016/j.bios.2013.02.007
58. [58]
  Li, H.; Zhang, W.; Zhou, H. Anal. Biochem. 2014, 449, 26. doi: 10.1016/j.ab.2013.12.019
59. [59]
  Choudhary, M.; Kumar, V.; Singh, A.; Singh, M. P.; Kaur, S.; Reddy, G. B.; Pasricha, R.; Singh, S. P.; Arora, K. Biosens. Bioelectron. 2013, 4, 4.
60. [60]
  Ojeda, I.; Moreno-Guzman, M.; Gonzalez-Cortes, A.; Yanez-Sedeno, P.; Pingarron, J. M. Anal. Bioanal. Chem. 2014, 406(25), 6363. doi: 10.1007/s00216-014-8055-6
61. [61]
  Martínez-García, G.; Serafín, V.; Agüí, L.; Yáñez-Sedeño, P.; Pingarrón, J. M. Electroanalysis. 2015, 27(5), 1119. doi: 10.1002/elan.201400662
62. [62]
  Kumar, S.; Sharma, J. G.; Maji, S.; Malhotra, B. D. Biosens. Bioelectron. 2016, 78, 497. doi: 10.1016/j.bios.2015.11.084
63. [63]
  Braiek, M.; Yang, Y.; Farre, C.; Chaix, C.; Bessueille, F.; Baraket, A.; Errachid, A.; Zhang, A.; Jaffrezic-Renault, N. Electroanalysis 2016, 28(8), 1810. doi: 10.1002/elan.201600060
64. [64]
  Aydin, E. B.; Sezginturk, M. K. Anal. Biochem. 2018, 554, 44. doi: 10.1016/j.ab.2018.05.030
65. [65]
  Verma, S.; Singh, A.; Shukla, A.; Kaswan, J.; Arora, K.; Ramirez-Vick, J.; Singh, P.; Singh, S. P. ACS Appl. Mater. Interfaces 2017, 9(33), 27462. doi: 10.1021/acsami.7b06839
66. [66]
  Aydın, E. B.; Aydın, M.; Sezgintürk, M. K. Sens. Actuators, B. 2018, 270, 18.
67. [67]
  Choudhary, M.; Yadav, P.; Singh, A.; Kaur, S.; Ramirez-Vick, J.; Chandra, P.; Arora, K.; Singh, S. P. Electroanalysis 2016, 28(10), 2565. doi: 10.1002/elan.201600238
68. [68]
  Kumar, S.; Sharma, J. G.; Maji, S.; Malhotra, B. D. RSC Adv. 2016, 6(80), 77037. doi: 10.1039/C6RA07392A
69. [69]
  Kumar, S.; Kumar, S.; Tiwari, S.; Srivastava, S.; Srivastava, M.; Yadav, B. K.; Kumar, S.; Tran, T. T.; Dewan, A. K.; Mulchandani, A.; Sharma, J. G.; Maji, S.; Malhotra, B. D. Adv. Sci. 2015, 2(8), 1500048. doi: 10.1002/advs.201500048
70. [70]
  Garcia, P. T.; Guimarães, L. N.; Dias, A. A.; Ulhoa, C. J.; Coltro, W. K. T. Sens. Actuators, B 2018, 258, 342. doi: 10.1016/j.snb.2017.11.068
71. [71]
  Aydin, E. B.; Aydin, M.; Sezginturk, M. K. Biosens. Bioelectron. 2017, 97, 169. doi: 10.1016/j.bios.2017.05.056
72. [72]
  Chen, Q.; Hu, W.; Shang, B.; Wei, J.; Chen, L.; Guo, X.; Ran, F.; Chen, W.; Ding, X.; Xu, Y.; Wu, Y. Microchim. Acta 2018, 185(3), 202. doi: 10.1007/s00604-018-2739-0
73. [73]
  Pasha, S. K.; Kaushik, A.; Vasudev, A.; Snipes, S. A.; Bhansali, S. J. Electrochem. Soc. 2013, 161(2), B3077.
74. [74]
  Cullum, B. M.; McLamore, E. S.; Vabbina, P. K.; Kaushik, A.; Tracy, K.; Bhansali, S. Pala N. 2014, 9107, 91070U.
75. [75]
  Cullum, B. M.; McLamore, E. S.; Vabbina, P. K.; Kaushik, A.; Tracy, K.; Bhansali, S. Anal. Chem. 2017, 89(3), 2107. doi: 10.1021/acs.analchem.6b04769
76. [76]
  Wang, X.; Wang, Y.; Jiang, M.; Shan, Y.; Jin, X.; Gong, M.; Wang, X. Anal. Biochem. 2018, 548, 15. doi: 10.1016/j.ab.2018.02.006
77. [77]
  Ahmed, A.; Rushworth, J. V.; Wright, J. D.; Millner, P. A. Anal. Chem. 2013, 85(24), 12118. doi: 10.1021/ac403253j
78. [78]
  Wei, F.; Lin, C. C.; Joon, A.; Feng, Z.; Troche, G.; Lira, M. E.; Chia, D.; Mao, M.; Ho, C. L.; Su, W. C.; Wong, D. T. Am. J. Respir. Crit. Care Med. 2014, 190(10), 1117. doi: 10.1164/rccm.201406-1003OC
79. [79]
  Serafin, V.; Martinez-Garcia, G.; Agui, L.; Yanez-Sedeno, P.; Pingarron, J. M. The Analyst. 2014, 139(18), 4556. doi: 10.1039/C4AN00221K
80. [80]
  Martínez-García, G.; Agüí, L.; Yáñez-Sedeño, P.; Pingarrón, J. M. Electrochim. Acta 2016, 202, 209. doi: 10.1016/j.electacta.2016.03.140
81. [81]
  Sanchez-Tirado, E.; Salvo, C.; Gonzalez-Cortes, A.; Yanez-Sedeno, P.; Langa, F.; Pingarron, J. M. Anal. Chim. Acta 2017, 959, 66. doi: 10.1016/j.aca.2016.12.034
82. [82]
  Lee, P. T.; Compton, R. G. Sens. Actuators, B 2015, 209, 983. doi: 10.1016/j.snb.2014.12.070
83. [83]
  Torrente-Rodriguez, R. M.; Campuzano, S.; Ruiz-Valdepenas Montiel, V.; Gamella, M.; Pingarron, J. M. Biosens. Bioelectron. 2016, 77, 543. doi: 10.1016/j.bios.2015.10.016
1. [1]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
2. [2]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
3. [3]
  Yang Liu , Peng Chen , Lei Liu . Chemistry “101 Plan”: Design and Construction of Chemical Biology Textbook. University Chemistry, 2024, 39(10): 45-51. doi: 10.12461/PKU.DXHX202407085
4. [4]
  Tianyu Feng , Guifang Jia , Peng Zou , Jun Huang , Zhanxia Lü , Zhen Gao , Chu Wang . Construction of the Chemistry Biology Experiment Course in the Chemistry “101 Program”. University Chemistry, 2024, 39(10): 69-77. doi: 10.12461/PKU.DXHX202409002
5. [5]
  Xinyi Hong , Tailing Xue , Zhou Xu , Enrong Xie , Mingkai Wu , Qingqing Wang , Lina Wu . Non-Site-Specific Fluorescent Labeling of Proteins as a Chemical Biology Experiment. University Chemistry, 2024, 39(4): 351-360. doi: 10.3866/PKU.DXHX202310010
6. [6]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
7. [7]
  Zian Lin , Yingxue Jin . Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) for Disease Marker Screening and Identification: A Comprehensive Experiment Teaching Reform in Instrumental Analysis. University Chemistry, 2024, 39(11): 327-334. doi: 10.12461/PKU.DXHX202403066
8. [8]
  Shengbiao Zheng , Liang Li , Nini Zhang , Ruimin Bao , Ruizhang Hu , Jing Tang . Metal-Organic Framework-Derived Materials Modified Electrode for Electrochemical Sensing of Tert-Butylhydroquinone: A Recommended Comprehensive Chemistry Experiment for Translating Research Results. University Chemistry, 2024, 39(7): 345-353. doi: 10.3866/PKU.DXHX202310096
9. [9]
  Qin Hou , Jiayi Hou , Aiju Shi , Xingliang Xu , Yuanhong Zhang , Yijing Li , Juying Hou , Yanfang Wang . Preparation of Cuprous Iodide Coordination Polymer and Fluorescent Detection of Nitrite: A Comprehensive Chemical Design Experiment. University Chemistry, 2024, 39(8): 221-229. doi: 10.3866/PKU.DXHX202312056
10. [10]
  Tiantian MA , Sumei LI , Chengyu ZHANG , Lu XU , Yiyan BAI , Yunlong FU , Wenjuan JI , Haiying YANG . Methyl-functionalized Cd-based metal-organic framework for highly sensitive electrochemical sensing of dopamine. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 725-735. doi: 10.11862/CJIC.20230351
11. [11]
  Sifang Zhang , Yanli Tan , Yu Tao , Jiaoyan Zhao , Haihong Zhu . Exploration and Practice of Ideological and Political Cases in the Course of Chemistry History and Methodology. University Chemistry, 2024, 39(10): 377-388. doi: 10.12461/PKU.DXHX202312067
12. [12]
  Tongyu Zheng , Teng Li , Xiaoyu Han , Yupei Chai , Kexin Zhao , Quan Liu , Xiaohui Ji . A DIY pH Detection Agent Using Persimmon Extract for Acid-Base Discoloration Popularization Experiment. University Chemistry, 2024, 39(5): 27-36. doi: 10.3866/PKU.DXHX202309107
13. [13]
  Xiaofeng Zhu , Bingbing Xiao , Jiaxin Su , Shuai Wang , Qingran Zhang , Jun Wang . Transition Metal Oxides/Chalcogenides for Electrochemical Oxygen Reduction into Hydrogen Peroxides. Acta Physico-Chimica Sinica, 2024, 40(12): 2407005-. doi: 10.3866/PKU.WHXB202407005
14. [14]
  Hongbo Zhang , Yihong Tang , Suxia Zhang , Yuanting Li . Electrochemical Monitoring of Photocatalytic Degradation of Phenol Pollutants: A Recommended Comprehensive Analytical Chemistry Experiment. University Chemistry, 2024, 39(6): 326-333. doi: 10.3866/PKU.DXHX202310013
15. [15]
  Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb₂ complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357
16. [16]
  Caixia Lin , Zhaojiang Shi , Yi Yu , Jianfeng Yan , Keyin Ye , Yaofeng Yuan . Ideological and Political Design for the Electrochemical Synthesis of Benzoxathiazine Dioxide Experiment. University Chemistry, 2024, 39(2): 61-66. doi: 10.3866/PKU.DXHX202309005
17. [17]
  Lu XU , Chengyu ZHANG , Wenjuan JI , Haiying YANG , Yunlong FU . Zinc metal-organic framework with high-density free carboxyl oxygen functionalized pore walls for targeted electrochemical sensing of paracetamol. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 907-918. doi: 10.11862/CJIC.20230431
18. [18]
  Jing SU , Bingrong LI , Yiyan BAI , Wenjuan JI , Haiying YANG , Zhefeng Fan . Highly sensitive electrochemical dopamine sensor based on a highly stable In-based metal-organic framework with amino-enriched pores. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1337-1346. doi: 10.11862/CJIC.20230414
19. [19]
  Min Gu , Huiwen Xiong , Liling Liu , Jilie Kong , Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120
20. [20]
  Jianfeng Yan , Yating Xiao , Xin Zuo , Caixia Lin , Yaofeng Yuan . Comprehensive Chemistry Experimental Design of Ferrocenylphenyl Derivatives. University Chemistry, 2024, 39(4): 329-337. doi: 10.3866/PKU.DXHX202310005

Get Citation

PDF

XML

Metrics

PDF Downloads(43)
Abstract views(2575)
HTML views(498)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142