Citation: Wang Ze, Wong Y. -L. Elaine, Ren Juan, Chen Xiangfeng, Chan T. -W. Dominic. Recent Progress on Electron Capture Dissociation Mass Spectrometry[J]. Acta Chimica Sinica, ;2019, 77(2): 130-142. doi: 10.6023/A18090363 shu

Recent Progress on Electron Capture Dissociation Mass Spectrometry

a.
Key Laboratory of Fundamental and Applied Research of Traditional Chinese Medicine, Zunyi Medical University at Zhuhai Campus, Zhuhai 519090
b.
Department of Chemistry, The Chinese University of Hong Kong, Hong Kong SAR
c.
Instrumental Analysis and Testing Center, Shandong Academy of Science, Jinan 250014

Corresponding author: Chen Xiangfeng, xiangfchensdas@163.com Chan T. -W. Dominic, twdchan@cuhk.edu.hk
Received Date: 2 September 2018
Available Online: 24 February 2018
Fund Project: the Natural Science Foundation of Shandong Province ZR2017MB011the Research Grant Council of the Hong Kong Special Administrative Region 4053152the Research Grant Council of the Hong Kong Special Administrative Region 3132667Project supported by the National Natural Science Foundation of China (No. 21205071), the Research Grant Council of the Hong Kong Special Administrative Region (Nos. 3132667 & 4053152) and the Natural Science Foundation of Shandong Province (No. ZR2017MB011)the National Natural Science Foundation of China 21205071

Figures(20)

In the past twenty years, our knowledge on gas phase radical ion chemistry has been significantly improved due to the development of electron capture dissociation. Combined with soft ionization method, it has shown the technique can provide novel fragment ions for the structural elucidation of biomolecules, especially for protein characterization. This review aims to introduce fundamental aspects of electron capture dissociation mass spectrometry, as well as its applications in the analysis of biomolecules.
- mass spectrometry,
- electron capture dissociation,
- gas phase ion chemistry,
- protein characterization
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