Citation: Wang Jie, Chen Peng. Development and Applications of Bioorthogonal Cleavage Reactions[J]. Acta Chimica Sinica, ;2017, 75(12): 1173-1182. doi: 10.6023/A17090419 shu

Development and Applications of Bioorthogonal Cleavage Reactions

Wang Jie ^a,b ,
Chen Peng ^a,b,,

a.
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871
b.
Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871

Corresponding author: Chen Peng, pengchen@pku.edu.cn
Received Date: 14 September 2017
Available Online: 9 December 2017
Fund Project: the National Natural Science Foundation of China 21432002the National Natural Science Foundation of China 21521003Project supported by the National Natural Science Foundation of China (Nos. 21521003, 21432002)

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Bioorthogonal reactions enable us to study and manipulate biological processes under living conditions. As widely used and powerful tools, biorthogonal reactions are largely defined as "ligation reactions" that are used for labeling, tracing and capturing biomolecules. Recently, an emerging collection of biorthogonal "bond-cleavage reactions" have been developed and applied for biological studies, especially in releasing, activating and manipulating biomolecules. In this review, we will first summarize the characteristics and applications of these biorthogonal cleavage reactions. We will then focus on introducing diverse applications of biorthogonal cleavage reactions, including activation of prodrugs, rescue of intracellular protein activity, engineering of cell surface, among other interesting applications. Finally, the outlook of future development and applications of biorthogonal cleavage reactions will be discussed.
- biorthogonal cleavage reaction,
- protein activation,
- pro-drug,
- unnatural amino acids,
- chemical decaging
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