Citation: Wang Dehong, Zhang Long, Luo Sanzhong. Photo-induced Catalytic Asymmetric Free Radical Reactions[J]. Acta Chimica Sinica, ;2017, 75(1): 22-33. doi: 10.6023/A16080418 shu

Photo-induced Catalytic Asymmetric Free Radical Reactions

Wang Dehong ^a,b ,
Zhang Long ^a,b ,
Luo Sanzhong ^a,b,*,,

a.
Key Laboratory of Molecular Recognition and Functions, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190
b.
University of Chinese Academy of Sciences, Beijing 100049

Corresponding author: Luo Sanzhong, luosz@iccas.ac.cn
Received Date: 16 August 2016

Fund Project: the National Natural Science Foundation of China 21390400the National Natural Science Foundation of China 21572232

Figures(19)

Enantioselective control of free radical reactions has eluded organic chemists for decades. Echoed with the renaissance of photo-induced processes, or so called photocatalysis or photoredox catalysis in organic synthesis, photo-induced organic radical chemistry has regained its prominence in developing catalytic asymmetric radical reaction. The generally mild conditions inherited with photochemistry, particularly visible light photo-processes, have allowed for controllable generation of free radicals as well as the subsequent bond formations. The past five years have witnessed dramatic advances in exploring photo-induced catalytic asymmetric free radical reactions, and enormous potentials along this line are envisaged. This perspective gives a brief summary on the important advances in this field. Accordingly, the major advances are classified based on different radical species including α-amino/oxyl radicals, radicals generated from enones and its analogues, benzyl radicals, α-carbonyl radicals, polyhalogenated alkyl radicals and nitrogen radicals. Brief discussion of mechanism is presented whenever relevant.
- photoredox catalysis,
- free radical reaction,
- asymmetric catalysis,
- synergistic catalysis
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