Citation: LI Peng-Yu, LU Li-Ping. PTPs Inhibition by Some Oxovanadium Complexes with Bioligands[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(9): 1830-1834. doi: 10.3969/j.issn.1001-4861.2013.00.229 shu

PTPs Inhibition by Some Oxovanadium Complexes with Bioligands

LI Peng-Yu ,
LU Li-Ping

1.
Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering, Ministry of Education, Shanxi University, Taiyuan 030006, China

Received Date: 14 January 2013
Available Online: 22 March 2013
Fund Project: 国家自然科学基金(No.21171109) (No.21171109)山西省自然科学基金(2011011009-1) (2011011009-1)山西省回国留学人员科研课题(2012-004)资助项目。 (2012-004)

The inhibition of PTPs which dephosphorylate the insulin receptor, resulting in prolongation of insulin signaling, is involved in the mechanism of vanadiums insulin-sensitizing effects. Here, the speicies of vanadium complexes in the solution with bioligands to oxovanadium ions of 20:1 molar ratio are investigated by UV-Vis spectra, and their inhibition over protein tyrosine phosphatases are evaluated. The results show that in the solution, amino acids are coordinated to oxovanadium ions to form 2:1 vanadium complexes, but ascorbic acid, citric acid, iminodiacetic acid and malic acid form 1:1 vanadium complexes. The inhibitions against protein tyrosine phosphatases indicate among 19 systems of 20:1 molar ratio of bioligands to VO(Ⅱ), 14 systems exhibit strong inhibition over PTP1B (protein tyrosine phosphatase 1B) with IC₅₀ of 0.12~0.63 μmol·L^-1, and[VO(Phe)₂] system displays strongest inhibition with IC₅₀ of 0.07 μmol·L^-1 while[VO(Arg)₂],[VO(Oxalate)],[VO(Nitrilotriacetate] and[VO(Citrate)] systems show weaker inhibition with IC₅₀ about 1.05, 1.41, 9.90 and 21.5 μmol·L^-1, respectively. The selectivity of[VO(Arg)₂],[VO(Tyr)₂],[VO(Phe)₂],[VO(Malate)],[VO(Lactate)] and[VO(Citrate)] systems over PTP1B, TCPTP (T-cell protein tyrosine phosphatase), HePTP (Hematopoietic protein tyrosine phosphatase) and SHP-1 (Src homology phosphatase 1) show the inhibitions against four PTPs are varied with the change of the bioligands, suggesting the structures of the bioligands influence the potency of the PTPs inhibition and the selectivity.
- bioligands;oxovanadium complexs;protein tyrosine phosphatase (PTP);inhibition;selectivity
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