Citation: ZHAO Yue, HAN Xiao, ZHOU Xiao-Xia, LI Hai-Hua, YOU Zhong-Lu. Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(Ⅴ) Complexes with Hydrazones[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(4): 867-874. doi: 10.3969/j.issn.1001-4861.2013.00.140 shu

Synthesis, Structures, and Helicobacter Pylori Urease Inhibition of Oxovanadium(Ⅴ) Complexes with Hydrazones

1.
1 Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China;

Received Date: 27 December 2012
Available Online: 17 January 2013
Fund Project: 国家自然科学基金(No.20901036) (No.20901036) 辽宁省高校优秀青年人才支持计划(No.LJQ2011114)资助项目。 (No.LJQ2011114)

In order to explore new and efficient urease inhibitors, two new oxovanadium(Ⅴ) complexes, [VOL¹(OCH₃)(CH₃OH)] (1) and [VOL₂(μ-OCH₃)]₂ (2) (H₂L¹=N′-(5-chloro-2-hydroxybenzylidene)-3-nitrobenzohydrazide; H₂L₂=N′-(5-chloro-2-hydroxybenzylidene)-4-chlorobenzohydrazide), have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. Compound 1 is a mononuclear complex, and compound 2 is a bis-methanolato bridged centrosymmetric dinuclear complex. The V atom in each complex adopts an octahedral coordination. Thermal stability and urease inhibitory activities of the complexes were studied. The percent inhibition at the concentration of 100 μmol·L^-1 on Helicobacter pylori urease is 71.4% for 1 and 73.3% for 2. The IC₅₀ values for 1 and 2 are 63.6 and 37.7 μmol·L^-1, respectively. CCDC: 858857, 1; and 858858, 2.
- hydrazone;oxovanadium(Ⅴ) complex;crystal structure;urease;inhibitor
1. [1]
  [1] Francisco S S, Urrutia O, Martin V, et al. J. Sci. Food Agr., 2011,91:1569-1575
2. [2]
  [2] Xiao Z P, Ma T W, Fu W C, et al. Eur. J. Med. Chem., 2010,45:5064-5070
3. [3]
  [3] Barros T G, Williamson J S, Antunes O A C, et al. Lett. Drug Des. Discovery, 2009,6:186-192
4. [4]
  [4] CHEN Fu(陈浮), YANG Gui-Shan(杨桂山), CAO Hui(曹慧), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2002, 18(8):827-832
5. [5]
  [5] Louie A Y, Meade T J. Chem. Rev., 1999,99:2711-2734
6. [6]
  [6] Bernhardt P V, Chin P, Sharpe P C, et al. Dalton Trans., 2007,30:3232-3244
7. [7]
  [7] Bernhardt P V, Wilson G J, Sharpe P C, et al. J. Biol. Inorg. Chem., 2008,13:107-119
8. [8]
  [8] Yaul A R, Dhande V V, Suryawanshi N J, et al. Polish J. Chem., 2009,83:565-571
9. [9]
  [9] WANG Hui(王慧), GAN Guo-Qing(甘国庆), QU Yang(瞿阳), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2012,28(6):1217-1221
10. [10]
  [10] SUN Gang-Chun(孙纲春), QU Jian-Qiang(曲建强), WANG Liu-Fang(王流芳), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2005,21(7):1069-1072
11. [11]
  [11] Willsky G R, Goldfine A B, Kostyniak P J, et al. J. Inorg. Biochem., 2001,85:33-42
12. [12]
  [12] Orvig C, Caravan P, Gelmini L, et al. J. Am. Chem. Soc., 1995,117:12759-12770
13. [13]
  [13] Messerschmidt A, Prade L, Wever R. Biol. Chem., 1997, 378:309-315
14. [14]
  [14] BIAN Lin(边琳), LI Lian-Zhi(李连之), WANG Xia(王霞), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2011, 27(4):649-654
15. [15]
  [15] Ara R, Ashiq U, Mahroof-Tahir M, et al. Chem. Biodivers., 2007,4:58-71
16. [16]
  [16] Aslam M A S, Mahmood S, Shahid M, et al. Eur. J. Med. Chem., 2011,46:5473-5479
17. [17]
  [17] ZHANG Ji-Cai(张吉才), LI Hai-Hua(李海华), XIAN Dong-Mei(献冬梅), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2012,28(9):1959-1966
18. [18]
  [18] You Z L, Shi D H, Zhang J C, et al. Inorg. Chim. Acta, 2012,384:54-61
19. [19]
  [19] Bruker, SMART and SAINT. Bruker AXS Inc, Madison, 2002.
20. [20]
  [20] Sheldrick G M. SADABS. University of Göttingen, Germany, 1996.
21. [21]
  [21] Sheldrick G M. SHELXTL V5.1, Software Reference Manual, Bruker AXS Inc, Madison, 1997.
22. [22]
  [22] Mao W J, Lü P C, Shi L, et al. Bioorg. Med. Chem., 2009, 17:7531-7536
23. [23]
  [23] Weatherburn M W. Anal. Chem., 1967,39:971-974
24. [24]
  [24] Geary W J. Coord. Chem. Rev., 1971,7:81-122
25. [25]
  [25] LIU Jiu-Hui(刘九辉), WU Xiao-Yuan(吴小园), ZHANG Quan-Zheng(张全争), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2006,22(6):1028-1032
26. [26]
  [26] DENG Zhao-Peng(邓兆鹏), GAO Shan(高山), ZHAO Hui(赵辉), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2007,23(1):173-176
27. [27]
  [27] Sangeetha N R, Kavita V, Wocadlo S, et al. J. Coord. Chem., 2000,51:55-66
28. [28]
  [28] Cui Y M, Cai Y J, Chen W. Synth. React. Inorg. Met.-Org. Nano-Met. Chem., 2011,41:1244-1248
29. [29]
  [29] WANG Ming-Ming(王明明), XIE A-Gui(谢阿贵), WANG Hui(王慧), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2009,25(5):942-945
30. [30]
  [30] XU Hui-Yan(徐会艳), WANG Hai-Ying(王海营), NIU De-Zhong(牛德仲), et al. Chinese J. Inorg. Chem.(Wuji Huaxue Xuebao), 2007,23(4):611-614
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