Citation: Zhan Jinxiu, Feng Feng, Xu Ming, Yao Li, Ge Maofa. Progress in Chemo–Mechanical Interactions between Nanoparticles and Cells[J]. Acta Physico-Chimica Sinica, ;2020, 36(1): 190507. doi: 10.3866/PKU.WHXB201905076 shu

Progress in Chemo–Mechanical Interactions between Nanoparticles and Cells

Zhan Jinxiu ^1,2 ,
Feng Feng ^1,2 ,
Xu Ming ^1,2 ,
Yao Li ^1,2,, ,
Ge Maofa ^1,2,,

1.
Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
2.
University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Corresponding author: Yao Li, yaoli@iccas.ac.cn Ge Maofa, gemaofa@iccas.ac.cn
Received Date: 28 May 2019
Revised Date: 5 July 2019
Accepted Date: 8 July 2019
Available Online: 18 January 2019
Fund Project: the National Key Research and Development Program of China 2018YFA0208800the Beijing Natural Science Foundation, China L172048the National Natural Science Foundation of China 21778055The project was supported by the National Natural Science Foundation of China (21778055, 21573250), the National Key Research and Development Program of China (2018YFA0208800), and the Beijing Natural Science Foundation, China (L172048)the National Natural Science Foundation of China 21573250

The biosafety of nanoparticles is gaining extensive attention due to their dichotomous effects in fields of biomedicine and atmospheric chemistry. A number of studies have been carried out focusing on the cytotoxicity of nanoparticles and their interactions with cells. However, the mechanism of nanoparticle–cell interactions remains unclear. Here, we review the latest progress in the study of nanoparticle-cell interactions from a cellular chemo-mechanical perspective. Cell mechanics play an important role in cell differentiation, proliferation, apoptosis, polarization, adhesion, and migration. An understanding of the effects of nanoparticles on cell mechanics is therefore needed in order to enhance comprehension of nanoparticle–cell interactions. Firstly, the main molecules and signal pathways related to mechanical chemistry are introduced from three perspectives: cell surface adhesion receptors, the cytoskeleton, and the nucleus. Specifically, integrins and cadherins play a critical role in sensing both the external mechanical force and the force of cell transmission. Actin and microtubules, which are two components of the cytoskeletal network, act as a bridge in mechanical conduction. The nucleus can also be mechanically stressed by the surrounding cytoskeleton through the contraction of the matrix. The nuclear envelope also plays important roles in sensing mechanical signals and in adjusting the morphology and function of the nucleus. We summarize the major nanoparticle-based tools used in the laboratory for the study of cell mechanics, which includes traction force microscopy, atomic force microscopy, optical tweezers, magnetic manipulation, micropillars, and force-induced remnant magnetization spectroscopy. In addition, we discuss the effects that nanoparticles have on cell mechanics. Nanoparticles interact with the adhesion of molecules on the cell membrane surface and on cell cytoskeletal proteins, which further affects the mechanical properties involved in cell stiffness, cell adhesion, and cell migration. Overall, the general conclusions regarding the effects of nanoparticles on cell mechanics are as follows: (1) Nanoparticles can affect cell adhesion by disrupting tight and adherent junctions, and by regulating cell-extracellular matrix adhesion; (2) Nanoparticles can interact with cytoskeletal proteins (actins and tubulins) leading to structural reorganization or disruption of microtubules and F-actin; (3) Cell stiffness changes with the structural reorganization of the cytoskeleton; (4) Cell migration ability can be affected through changes in the cytoskeleton, cell adhesion, and the expression of cell migration-related proteins/molecules. To develop the nano-biosafety evaluation system, future studies should attempt to gain a better understanding of the molecular mechanisms involved with regards to nanoparticles and cell mechanics. Ultimately, further development of new methods and technologies based on nano-mechanical chemistry for diagnosis and treatment purposes are expected, given the wide application of nanomaterials in the biomedical field.
- Nanoparticle,
- Cell,
- Mechanotransduction,
- Interaction,
- Mechanochemical coupling
1. [1]
  Grabinski, C.; Schaeublin, N.; Wijaya, A.; D'Couto, H.; Baxamusa, S. H.; Hamad-Schifferli, K.; Hussain, S. M. ACS Nano 2011, 5 (4), 2870. doi: 10.1021/nn103476x doi: 10.1021/nn103476x
2. [2]
  Pati, R.; Das, I.; Mehta, R. K.; Sahu, R.; Sonawane, A. Toxicol. Sci. 2016, 150 (2), 454. doi: 10.1093/toxsci/kfw010 doi: 10.1093/toxsci/kfw010
3. [3]
  Li, J. C.; Mao, H. L.; Kawazoe, N.; Chen, G. P. Biomater. Sci. 2017, 5 (2), 173. doi: 10.1039/c6bm00714g doi: 10.1039/c6bm00714g
4. [4]
  Rotsch, C.; Radmacher, M. Biophys. J. 2000, 78 (1), 520. doi: 10.1016/s0006-3495(00)76614-8 doi: 10.1016/s0006-3495(00)76614-8
5. [5]
  Tay, C. Y.; Cai, P. Q.; Setyawati, M. I.; Fang, W. R.; Tan, L. P.; Hong, C. H. L.; Chen, X. D.; Leong, D. T. Nano Lett. 2014, 14 (1), 83. doi: 10.1021/nl4032549 doi: 10.1021/nl4032549
6. [6]
  Li, Y.; Jing, L.; Yu, Y. B.; Yu, Y.; Duan, J. C.; Yang, M.; Geng, W. J.; Jiang, L. Z.; Li, Q. L.; Sun, Z. W. Part. Part. Syst. Charact. 2015, 32 (6), 636. doi: 10.1002/ppsc.201400180 doi: 10.1002/ppsc.201400180
7. [7]
  Nakayama, K. H.; Surya, V. N.; Gole, M.; Walker, T. W.; Yang, W. G.; Lai, E. S.; Ostrowski, M. A.; Fuller, G. G.; Dunn, A. R.; Huang, N. F. Nano Lett. 2016, 16 (1), 410. doi: 10.1021/acs.nanolett.5b04028 doi: 10.1021/acs.nanolett.5b04028
8. [8]
  Hynes, R. O. Cell 2002, 110 (6), 673. doi: 10.1016/s0092-8674(02)00971-6 doi: 10.1016/s0092-8674(02)00971-6
9. [9]
  Guo, W. J.; Giancotti, F. G. Nat. Rev. Mol. Cell Biol. 2004, 5 (10), 816. doi: 10.1038/nrm1490 doi: 10.1038/nrm1490
10. [10]
  Mitra, S. K.; Hanson, D. A.; Schlaepfer, D. D. Nat. Rev. Mol. Cell Biol. 2005, 6 (1), 56. doi: 10.1038/nrm1549 doi: 10.1038/nrm1549
11. [11]
  Li, Z. H.; Lee, H. J.; Zhu, C. Exp. Cell Res. 2016, 349 (1), 85. doi: 10.1016/j.yexcr.2016.10.001 doi: 10.1016/j.yexcr.2016.10.001
12. [12]
  Geiger, B.; Yamada, K. M. CSH Perspect. Biol. 2011, 3 (5), 21. doi: 10.1101/cshperspect.a005033 doi: 10.1101/cshperspect.a005033
13. [13]
  Jiang, G. Y.; Giannone, G.; Critchley, D. R.; Fukumoto, E.; Sheetz, M. P. Nature 2003, 424 (6946), 334. doi: 10.1038/nature01805 doi: 10.1038/nature01805
14. [14]
  Kukkurainen, S.; Maatta, J. A.; Saeger, J.; Valjakka, J.; Vogel, V.; Hytonen, V. P. Mol. Biosyst. 2014, 10 (12), 3217. doi: 10.1039/c4mb00341a doi: 10.1039/c4mb00341a
15. [15]
  Yao, M. X.; Goult, B. T.; Chen, H.; Cong, P. W.; Sheetz, M. P.; Yan, J. Sci. Rep. 2014, 4, 7. doi: 10.1038/srep04610 doi: 10.1038/srep04610
16. [16]
  Mitra, S. K.; Schlaepfer, D. D. Curr. Opin. Cell Biol. 2006, 18 (5), 516. doi: 10.1016/j.ceb.2006.08.011 doi: 10.1016/j.ceb.2006.08.011
17. [17]
  Beningo, K. A.; Dembo, M.; Kaverina, I.; Small, J. V.; Wang, Y. L. J. Cell Biol. 2001, 153 (4), 881. doi:10.1083/jcb.153.4.881 doi: 10.1083/jcb.153.4.881
18. [18]
  Scarpa, E.; Szabo, A.; Bibonne, A.; Theveneau, E.; Parsons, M.; Mayor, R. Dev. Cell 2015, 34 (4), 421. doi: 10.1016/j.devcel.2015.06.012 doi: 10.1016/j.devcel.2015.06.012
19. [19]
  Yao, M. X.; Qiu, W.; Liu, R. C.; Efremov, A. K.; Cong, P. W.; Seddiki, R.; Payre, M.; Lim, C. T.; Ladoux, B.; Mege, R. M.; et al. Nat. Commun. 2014, 5, 11. doi: 10.1038/ncomms5525 doi: 10.1038/ncomms5525
20. [20]
  Mui, K. L.; Chen, C. S.; Assoian, R. K. J. Cell Sci. 2016, 129 (6), 1093. doi: 10.1242/jcs.183699 doi: 10.1242/jcs.183699
21. [21]
  Auernheimer, V.; Lautscham, L. A.; Leidenberger, M.; Friedrich, O.; Kappes, B.; Fabry, B.; Goldmann, W. H. J. Cell Sci. 2015, 128 (18), 3435. doi: 10.1242/jcs.172031 doi: 10.1242/jcs.172031
22. [22]
  Gasparski, A. N.; Beningo, K. A. Arch. Biochem. Biophys. 2015, 586, 20. doi: 10.1016/j.abb.2015.07.017 doi: 10.1016/j.abb.2015.07.017
23. [23]
  Kiefel, H.; Bondong, S.; Hazin, J.; Ridinger, J.; Schirmer, U.; Riedle, S.; Altevogt, P. Cell Adhes. Migr. 2012, 6 (4), 374. doi: 10.4161/cam.20832 doi: 10.4161/cam.20832
24. [24]
  Colombo, F.; Meldolesi, J. Trends Pharmacol. Sci. 2015, 36 (11), 769. doi: 10.1016/j.tips.2015.08.004 doi: 10.1016/j.tips.2015.08.004
25. [25]
  Bershadsky, A.; Chausovsky, A.; Becker, E.; Lyubimova, A.; Geiger, B. Curr. Biol. 1996, 6 (10), 1279. doi: 10.1016/s0960-9822(02)70714-8 doi: 10.1016/s0960-9822(02)70714-8
26. [26]
  Padmakumar, V. C.; Libotte, T.; Lu, W. S.; Zaim, H.; Abraham, S.; Noegel, A. A.; Gotzmann, J.; Foisner, R.; Karakesisoglou, L. J. Cell Sci. 2005, 118 (15), 3419. doi: 10.1242/jcs.02471 doi: 10.1242/jcs.02471
27. [27]
  Haque, F.; Lloyd, D. J.; Smallwood, D. T.; Dent, C. L.; Shanahan, C. M.; Fry, A. M.; Trembath, R. C.; Shackleton, S. Mol. Cell. Biol. 2006, 26 (10), 3738. doi: 10.1128/mcb.26.10.3738-3751.2006 doi: 10.1128/mcb.26.10.3738-3751.2006
28. [28]
  Luxton, G. W. G.; Gomes, E. R.; Folker, E. S.; Vintinner, E.; Gundersen, G. G. Science 2010, 329 (5994), 956. doi: 10.1126/science.1189072 doi: 10.1126/science.1189072
29. [29]
  Guilluy, C.; Osborne, L. D.; Van Landeghem, L.; Sharek, L.; Superfine, R.; Garcia-Mata, R.; Burridge, K. Nat. Cell Biol. 2014, 16 (4), 376. doi: 10.1038/ncb2927 doi: 10.1038/ncb2927
30. [30]
  Fanucchi, S.; Shibayama, Y.; Burd, S.; Weinberg, M. S.; Mhlanga, M. M. Cell 2013, 155 (3), 606. doi: 10.1016/j.cell.2013.09.051 doi: 10.1016/j.cell.2013.09.051
31. [31]
  Dekker, J.; Mirny, L. Cell 2016, 164 (6), 1110. doi: 10.1016/j.cell.2016.02.007 doi: 10.1016/j.cell.2016.02.007
32. [32]
  Uhler, C.; Shivashankar, G. V. Nat. Rev. Mol. Cell Biol. 2017, 18 (12), 717. doi: 10.1038/nrm.2017.101 doi: 10.1038/nrm.2017.101
33. [33]
  Lv, L. W.; Tang, Y. M.; Zhang, P.; Liu, Y. S.; Bai, X. S.; Zhou, Y. S. Tissue Eng. Part B-Rev. 2018, 24 (2), 112. doi: 10.1089/ten.teb.2017.0287 doi: 10.1089/ten.teb.2017.0287
34. [34]
  Jaalouk, D. E.; Lammerding, J. Nat. Rev. Mol. Cell Biol. 2009, 10 (1), 63. doi: 10.1038/nrm2597 doi: 10.1038/nrm2597
35. [35]
  Schwarz, U. S.; Soine, J. R. D. Biochim. Biophys. Acta-Mol. Cell Res. 2015, 1853 (11), 3095. doi: 10.1016/j.bbamcr.2015.05.028 doi: 10.1016/j.bbamcr.2015.05.028
36. [36]
  Muller, D. J.; Dufrene, Y. F. Trends Cell Biol. 2011, 21 (8), 461. doi: 10.1016/j.tcb.2011.04.008 doi: 10.1016/j.tcb.2011.04.008
37. [37]
  Ahmed, W. W.; Fodor, E.; Betz, T. Biochim. Biophys. Acta-Mol. Cell Res. 2015, 1853 (11), 3083. doi: 10.1016/j.bbamcr.2015.05.022 doi: 10.1016/j.bbamcr.2015.05.022
38. [38]
  Castillo, M.; Ebensperger, R.; Wirtz, D.; Walczak, M.; Hurtado, D. E.; Celedon, A. J. Biomed. Mater. Res. Part B 2014, 102 (8), 1779. doi: 10.1002/jbm.b.33167 doi: 10.1002/jbm.b.33167
39. [39]
  Berret, J. F. Nat. Commun. 2016, 7, 10134. doi: 10.1038/ncomms10134 doi: 10.1038/ncomms10134
40. [40]
  Etoc, F.; Lisse, D.; Bellaiche, Y.; Piehler, J.; Coppey, M.; Dahan, M. Nat. Nanotechnol. 2013, 8 (3), 193. doi: 10.1038/nnano.2013.23 doi: 10.1038/nnano.2013.23
41. [41]
  Tan, J. L.; Tien, J.; Pirone, D. M.; Gray, D. S.; Bhadriraju, K.; Chen, C. S. Pro. Nat. Acad. Sci. U.S.A. 2003, 100 (4), 1484. doi: 10.1073/pnas.0235407100 doi: 10.1073/pnas.0235407100
42. [42]
  Yao, L.; Xu, S. J. Angew. Chem.-Int. Edit. 2011, 50 (19), 4407. doi: 10.1002/anie.201007297 doi: 10.1002/anie.201007297
43. [43]
  Yao, L.; Li, Y.; Tsai, T. W.; Xu, S. J.; Wang, Y. H. Angew. Chem. Int. Ed. 2013, 52 (52), 14041. doi: 10.1002/anie.201307419 doi: 10.1002/anie.201307419
44. [44]
  Yao, L.; Xu, S. J. J. Phys. Chem. B 2012, 116 (33), 9944. doi: 10.1021/jp304335a doi: 10.1021/jp304335a
45. [45]
  Zhang, D.; Feng, F.; Li, Q. L.; Wang, X. Y.; Yao, L. Biomaterials 2018, 173, 22. doi: 10.1016/j.biomaterials.2018.04.045 doi: 10.1016/j.biomaterials.2018.04.045
46. [46]
  Yu, C.; Zhang, D.; Feng, X.; Chai, Y.; Lu, P.; Li, Q.; Feng, F.; Wang, X.; Li, Y. Nanoscale 2019, 11 (16), 7648. doi: 10.1039/c8nr10338k doi: 10.1039/c8nr10338k
47. [47]
  Qin, Y.; Chen, K.; Gu, W.; Dong, X.; Lei, R.; Chang, Y.; Bai, X.; Xia, S.; Zeng, L.; Zhang, J.; et al. J. Nanobiotechnol. 2018, 16 (1), 54. doi: 10.1186/s12951-018-0380-z doi: 10.1186/s12951-018-0380-z
48. [48]
  Peng, F.; Setyawati, M. I.; Tee, J. K.; Ding, X. G.; Wang, J. P.; Nga, M. E.; Ho, H. K.; Leong, D. T. Nat. Nanotechnol. 2019, 14 (3), 279. doi: 10.1038/s41565-018-0356-z doi: 10.1038/s41565-018-0356-z
49. [49]
  Pottler, M.; Fliedner, A.; Schreiber, E.; Janko, C.; Friedrich, R. P.; Bohr, C.; Dollinger, M.; Alexiou, C.; Durr, S. Nanoscale Res. Lett. 2017, 12 (1), 284. doi: 10.1186/s11671-017-2045-5 doi: 10.1186/s11671-017-2045-5
50. [50]
  Li, Y.; Jing, L.; Yu, Y.; Yu, Y.; Duan, J.; Yang, M.; Geng, W.; Jiang, L.; Li, Q.; Sun, Z. Part. Part. Sys. Charact. 2015, 32 (6), 636. doi: 10.1002/ppsc.201400180 doi: 10.1002/ppsc.201400180
51. [51]
  Xie, H.; Wang, P.; Wu, J. Artif. Cells Nanomed Biotechnol. 2019, 47 (1), 260. doi: 10.1080/21691401.2018.1552594 doi: 10.1080/21691401.2018.1552594
52. [52]
  Soenen, S. J. H.; Nuytten, N.; De Meyer, S. F.; De Smedt, S. C.; De Cuyper, M. Small 2010, 6 (7), 832. doi: 10.1002/smll.200902084 doi: 10.1002/smll.200902084
53. [53]
  Qin, H.; Zhu, C.; An, Z.; Jiang, Y.; Zhao, Y.; Wang, J.; Liu, X.; Hui, B.; Zhang, X.; Wang, Y. Int. J. Nanomed. 2014, 9, 2469. doi: 10.2147/IJN.S59753 doi: 10.2147/IJN.S59753
54. [54]
  Calzado-Martin, A.; Encinar, M.; Tamayo, J.; Calleja, M.; Paulo, A. S. ACS Nano 2016, 10 (3), 3365. doi: 10.1021/acsnano.5b07162 doi: 10.1021/acsnano.5b07162
55. [55]
  Mao, H.; Li, J.; Dulinska-Molak, I.; Kawazoe, N.; Takeda, Y.; Mamiya, H.; Chen, G. Biomater. Sci. 2015, 3 (9), 1284. doi: 10.1039/c5bm00141b doi: 10.1039/c5bm00141b
56. [56]
  Ogneva, I. V.; Buravkov, S. V.; Shubenkov, A. N.; Buravkova, L. B. Nanoscale Res. Lett. 2014, 9. doi: 10.1186/1556-276x-9-284 doi: 10.1186/1556-276x-9-284
57. [57]
  Tian, X.; Yang, Z.; Duan, G.; Wu, A.; Gu, Z.; Zhang, L.; Chen, C.; Chai, Z.; Ge, C.; Zhou, R. Small 2017, 13 (3). doi: 10.1002/smll.201602133 doi: 10.1002/smll.201602133
58. [58]
  Sun, Q.; Kanehira, K.; Taniguchi, A. Sci. Technol. Adv. Mater. 2018, 19 (1), 271. doi: 10.1080/14686996.2018.1444318 doi: 10.1080/14686996.2018.1444318
59. [59]
  Vieira, L. F. A.; Lins, M. P.; Viana, I.; Dos Santos, J. E.; Smaniotto, S.; Reis, M. Nanoscale Res. Lett. 2017, 12 (1), 200. doi: 10.1186/s11671-017-1982-3 doi: 10.1186/s11671-017-1982-3
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