Citation: LIANG Shuang, GAO Ran, ZHANG Mengying, XUE Ning, QI Zhimei. Gold-Silver Alloy Film Based Spectral Surface Plasmon Resonance Imaging Sensor with High Sensitivity[J]. Acta Physico-Chimica Sinica, ;2019, 35(6): 630-636. doi: 10.3866/PKU.WHXB201806082 shu

Gold-Silver Alloy Film Based Spectral Surface Plasmon Resonance Imaging Sensor with High Sensitivity

LIANG Shuang ^1,2 ,
GAO Ran ¹ ,
ZHANG Mengying ¹ ,
XUE Ning ¹ ,
QI Zhimei ^1,,

1.
State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, P. R. China
2.
University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Corresponding author: QI Zhimei, zhimei-qi@mail.ie.ac.cn
Received Date: 27 April 2018
Revised Date: 4 June 2018
Accepted Date: 5 June 2018
Available Online: 8 June 2018
Fund Project: National Natural Science Foundation of China 61675203The project was supported by the National Key Basic Research Program of China (973)(2015CB352100), National Natural Science Foundation of China (61675203) and Research Equipment Development Project of Chinese Academy of Sciences (YZ201508)The project was supported by the National Key Basic Research Program of China (973) 2015CB352100Research Equipment Development Project of Chinese Academy of Sciences YZ201508

This paper reports, for the first time, a gold-silver alloy film based broadband spectral surface plasmon resonance imaging (SPRI) sensor that enables in situ quantitative detection of chemical and biological molecules adsorbed on the partial or entire surface of the alloy film. The use of the gold-silver alloy film as the sensing layer makes the SPRI sensor lower in detection cost and higher in detection sensitivity as compared with the conventional sensor with a pure gold film. The gold-silver alloy films of ~50 nm thicknesses were deposited on glass substrates using a sputtering target made of gold (50%)-silver (50%, w, mass fraction) alloy. Both the SPR spectra and SPR color images for the gold-silver alloy films covered with pure water were measured at different incident angles using the laboratory-made Krestchmann-type multifunctional platform. The two-dimensional (2D) hue profile and the average hue for each SPR color image were obtained by calculation with the hue algorithm. Using the average hue as the sensitivity parameter, the spectral SPRI sensor enables quantitative detection. The spectral range in which the average hue is most sensitive to refractive index (RI) changes of bulk solution and to molecular adsorption was determined to be between 595 and 610 nm. In this narrow spectral range the average hue is linearly dependent on the resonant wavelength and its slope (representing the hue variation induced by per unit change in resonant wavelength) is Δhue/Δλ_R = 7.52 nm^-1, implying that the hue-based RI sensitivity is 7.52 times as high as the wavelength-based RI sensitivity. This implication was experimentally demonstrated in this work. After setting the initial resonant wavelength of the sensor in the hue-sensitive spectral range, the hue-based RI sensitivity of the SPRI sensor was measured to be S = 29879 RIU^-1, which is 8 times higher than that obtained with the gold-film SPR chip under the same conditions (S = 3658 RIU^-1 for the gold-film SPR chip). Nonspecific adsorption of bovine serum albumin (BSA) molecules on the gold-silver alloy film was monitored in real time by the time-resolved spectral SPRI method, and the temporal change in the average hue was obtained. The time required for BSA adsorption to reach equilibrium is determined to be about 15 min. This study illustrates that the gold-silver alloy film based SPRI sensor has the powerful capability of quantitative detection of sub-monomolecular adsorption of proteins.
- Gold-silver alloy film,
- Broadband spectral SPR imaging,
- Hue,
- High sensitivity,
- Quantitative
1. [1]
  Yeatman, E.; Ash, E. A. Electron. Lett. 1987, 23 (20), 1091. doi: 10.1049/el:19870762 doi: 10.1049/el:19870762
2. [2]
  Rothenhäusler, B.; Knoll, W. Nature 1988, 332 (6165), 615. doi: 10.1038/332615a0 doi: 10.1038/332615a0
3. [3]
  Gobi, K. V.; Tanaka, H.; Shoyama, Y.; Miura, N. Biosens. Bioelectron. 2004, 20 (2), 350. doi: 10.1016/j.bios.2004.02.003
4. [4]
  Gifford, L. K.; Sendroiu, I. E.; Corn, R. M.; Lupták, A. J. Am. Chem. Soc. 2010, 132 (27), 9265. doi: 10.1021/ja103043p doi: 10.1021/ja103043p
5. [5]
  Zhou, W. J.; Halpern, A. R.; Seefeld, T. H.; Corn, R. M. Anal. Chem. 2012, 84 (1), 440. doi: 10.1021/ac202863k doi: 10.1021/ac202863k
6. [6]
  Yuk, J. S.; Kim, H. S.; Jung, J. W.; Jung, S. H.; Lee, S. J.; Kim, W. J.; Han, J. A.; Kim, Y. M.; Ha, K. S. Biosens. Bioelectron. 2008, 21 (8), 1521. doi: 10.1016/j.bios.2005.07.009 doi: 10.1016/j.bios.2005.07.009
7. [7]
  Knobloch, H.; Woigk, S.; Helms, A.; Brehmer, L. Appl. Phys. Lett. 1996, 69 (16), 2336. doi: 10.1063/1.117516 doi: 10.1063/1.117516
8. [8]
  Andersson, O.; Ulrich, C.; Bj refors, F.; Liedberg, B. Sens. Actuators B 2008, 134 (2), 545. doi: 10.1016/j.snb.2008.05.042 doi: 10.1016/j.snb.2008.05.042
9. [9]
  Beusink, J. B.; Lokate, A. M.; Besselink, G. A.; Pruijn, G. J.; Schasfoort, R. B. Biosens. Bioelectron. 2008, 23 (6), 839. doi: 10.1016/j.bios.2007.08.025 doi: 10.1016/j.bios.2007.08.025
10. [10]
  ) Zhang, P.; Liu, L.; He, Y.; Shen, Z. Y.; Guo, J. Appl. Opt. 2014, 53 (26), 6037. doi: 10.1364/AO.53.006037 doi: 10.1364/AO.53.006037
11. [11]
  Ho, H. P.; Wong, C. L.; Chan, K. S.; Wu, S. Y.; Lin, C. Appl. Opt. 2006, 45 (23), 5819. doi: 10.1364/AO.45.005819 doi: 10.1364/AO.45.005819
12. [12]
  Smith, A. R. Acm Siggraph Computer Graphics 1978, 12 (3), 12. doi: 10.1145/800248.807361 doi: 10.1145/800248.807361
13. [13]
  Liang, J. Q.; Cui, D. F.; Cai, H. Y.; Wang, J. B.; Wang, Y. J. Transd. Microsys. Technol. 2006, 25 (10), 57. doi: 10.3969/j.issn.1000-9787.2006.10.019
14. [14]
  Liu, W.; Chen, Y. Chem. J. Chin. Univ. 2008, 29 (9), 1744. doi: 10.3321/j.issn:0251-0790.2008.09.008
15. [15]
  Yu, X. L.; Wang, D. X.; Yan, Z. B. Sens. Actuators B 2003, 91 (1–3), 285. doi: 10.1016/S0925-4005(03)00105-9 doi: 10.1016/S0925-4005(03)00105-9
16. [16]
  Yu, X. L.; Ding, X.; Liu, F.; Deng, Y. Sens. Actuators B 2008, 130 (1), 52. doi: 10.1016/j.snb.2007.07.106 doi: 10.1016/j.snb.2007.07.106
17. [17]
  Shen, G. Y.; Chen, Y.; Zhang, Y. M.; Chen, Y.; Cui, J. Prog. Chem. 2010, 22 (8), 1648.
18. [18]
  Shen, G. Y.; Han, Z. Q.; Liu, W.; Chen, Y. Chem. J. Chin. Univ. 2007, 28 (9), 1651. doi: 10.3321/j.issn:0251-0790.2007.09032
19. [19]
  Fan, Z.B.; Gong, X. Q.; Lu, D. F.; Gao, R.; Deng, Y. H.; Qi, Z. M. Chin. J. Liq. Crys. Disp. 2017, 32 (5), 402. doi: 10.3788/YJYXS20173205.0402
20. [20]
  Fan, Z. B.; Gong, X. Q.; Lu, D. F.; Gao, R.; Qi, Z. M. Acta Phys. -Chim. Sin. 2017, 33 (5), 1001. doi: 10.3866/PKU.WHXB201701131
21. [21]
  ) Hodnik, V.; Anderluh, G. Sensors 2009, 9 (3), 1339. doi: 10.3390/s9031339 doi: 10.3390/s9031339
22. [22]
  ) Alleyne, C. J.; Kirk, A. G.; McPhedran, R. C.; Nicorovici, N. A. P.; Maystre, D. Opt. Express. 2007, 15 (13), 8163. doi: 10.1364/OE.15.008163 doi: 10.1364/OE.15.008163
23. [23]
  Manickam, G.; Gandhiraman, R.; Vijayaraghavan, R. K.; Kerr, L.; Doyle, C.; Williams, D. E.; Daniels, S. Analyst 2012, 137, 5265. doi: 10.1039/c2an35826c doi: 10.1039/c2an35826c
24. [24]
  Zhang, Z.; Liu, J.; Lu, D. F.; Qi, Z. M. Acta Phys. -Chim. Sin. 2014, 30 (9), 1771. doi: 10.3866/PKU.WHXB201407071
25. [25]
  Zhang, Z.; Liu, Q.; Qi, Z. M. Acta Phys. Sin. 2013, 62 (6), 81. doi: 10.7498/aps.62.060703
26. [26]
  Liu, D. L.; Zhao, Q.; Lu, D. F.; Qi, Z. M. Chem. J. Chin. Univ. 2014, 35 (10), 2207. doi: 10.7503/cjcu20140297
1. [1]
  Chenghe Yang , Yi Lü , Rui Liu . The Rise to Fame of Digital PCR. University Chemistry, 2025, 40(4): 340-345. doi: 10.12461/PKU.DXHX202406111
2. [2]
  Min Gu , Huiwen Xiong , Liling Liu , Jilie Kong , Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120
3. [3]
  Ling Bai , Limin Lu , Xiaoqiang Wang , Dongping Wu , Yansha Gao . Exploration and Practice of Teaching Reforms in “Quantitative Analytical Chemistry” under the Perspective of New Agricultural Science. University Chemistry, 2024, 39(3): 158-166. doi: 10.3866/PKU.DXHX202308101
4. [4]
  Mi Wen , Baoshuo Jia , Yongqi Chai , Tong Wang , Jianbo Liu , Hailong Wu . Improvement of Fluorescence Quantitative Analysis Experiment: Simultaneous Determination of Rhodamine 6G and Rhodamine 123 in Food Using Chemometrics-Assisted Three-Dimensional Fluorescence Method. University Chemistry, 2025, 40(4): 390-398. doi: 10.12461/PKU.DXHX202405147
5. [5]
  Wenxiu Yang , Jinfeng Zhang , Quanlong Xu , Yun Yang , Lijie Zhang . Bimetallic AuCu Alloy Decorated Covalent Organic Frameworks for Efficient Photocatalytic Hydrogen Production. Acta Physico-Chimica Sinica, 2024, 40(10): 2312014-. doi: 10.3866/PKU.WHXB202312014
6. [6]
  Xi Xu , Chaokai Zhu , Leiqing Cao , Zhuozhao Wu , Cao Guan . Experiential Education and 3D-Printed Alloys: Innovative Exploration and Student Development. University Chemistry, 2024, 39(2): 347-357. doi: 10.3866/PKU.DXHX202308039
7. [7]
  Xiao Liu , Guangzhong Cao , Mingli Gao , Hong Wu , Hongyan Feng , Chenxiao Jiang , Tongwen Xu . Seawater Salinity Gradient Energy’s Job Application in the Field of Membranes. University Chemistry, 2024, 39(9): 279-282. doi: 10.3866/PKU.DXHX202306043
8. [8]
  Shuyu Liu , Xiaomin Sun , Bohan Song , Gaofeng Zeng , Bingbing Du , Chongshen Guo , Cong Wang , Lei Wang . Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications. University Chemistry, 2024, 39(11): 182-188. doi: 10.12461/PKU.DXHX202404113
9. [9]
  Xiaohui Li , Ze Zhang , Jingyi Cui , Juanjuan Yin . Advanced Exploration and Practice of Teaching in the Experimental Course of Chemical Engineering Thermodynamics under the “High Order, Innovative, and Challenging” Framework. University Chemistry, 2024, 39(7): 368-376. doi: 10.3866/PKU.DXHX202311027
10. [10]
  Jiao CHEN , Yi LI , Yi XIE , Dandan DIAO , Qiang XIAO . Vapor-phase transport of MFI nanosheets for the fabrication of ultrathin b-axis oriented zeolite membranes. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 507-514. doi: 10.11862/CJIC.20230403
11. [11]
  Shengjuan Huo , Xiaoyan Zhang , Xiangheng Li , Xiangning Li , Tianfang Chen , Yuting Shen . Unveiling the Marvels of Titanium: Popularizing Multifunctional Colored Titanium Product Films. University Chemistry, 2024, 39(5): 184-192. doi: 10.3866/PKU.DXHX202310127
12. [12]
  Lan Ma , Cailu He , Ziqi Liu , Yaohan Yang , Qingxia Ming , Xue Luo , Tianfeng He , Liyun Zhang . Magical Surface Chemistry: Fabrication and Application of Oil-Water Separation Membranes. University Chemistry, 2024, 39(5): 218-227. doi: 10.3866/PKU.DXHX202311046
13. [13]
  Tianqi Bai , Kun Huang , Fachen Liu , Ruochen Shi , Wencai Ren , Songfeng Pei , Peng Gao , Zhongfan Liu . 石墨烯厚膜热扩散系数与微观结构的关系. Acta Physico-Chimica Sinica, 2025, 41(3): 2404024-. doi: 10.3866/PKU.WHXB202404024
14. [14]
  Yiping HUANG , Liqin TANG , Yufan JI , Cheng CHEN , Shuangtao LI , Jingjing HUANG , Xuechao GAO , Xuehong GU . Hollow fiber NaA zeolite membrane for deep dehydration of ethanol solvent by vapor permeation. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 225-234. doi: 10.11862/CJIC.20240224
15. [15]
  Jiahao Lu , Xin Ming , Yingjun Liu , Yuanyuan Hao , Peijuan Zhang , Songhan Shi , Yi Mao , Yue Yu , Shengying Cai , Zhen Xu , Chao Gao . 基于稳态电热法的石墨烯膜导热系数的精确可靠测量. Acta Physico-Chimica Sinica, 2025, 41(5): 100045-. doi: 10.1016/j.actphy.2025.100045
16. [16]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
17. [17]
  Tiantian MA , Sumei LI , Chengyu ZHANG , Lu XU , Yiyan BAI , Yunlong FU , Wenjuan JI , Haiying YANG . Methyl-functionalized Cd-based metal-organic framework for highly sensitive electrochemical sensing of dopamine. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 725-735. doi: 10.11862/CJIC.20230351
18. [18]
  Liang TANG , Jingfei NI , Kang XIAO , Xiangmei LIU . Synthesis and X-ray imaging application of lanthanide-organic complex-based scintillators. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1892-1902. doi: 10.11862/CJIC.20240139
19. [19]
  Wenliang Wang , Weina Wang , Lixia Feng , Nan Wei , Sufan Wang , Tian Sheng , Tao Zhou . Proof and Interpretation of Severe Spectroscopic Selection Rules. University Chemistry, 2025, 40(3): 415-424. doi: 10.12461/PKU.DXHX202408063
20. [20]
  Yan LIU , Jiaxin GUO , Song YANG , Shixian XU , Yanyan YANG , Zhongliang YU , Xiaogang HAO . Exclusionary recovery of phosphate anions with low concentration from wastewater using a CoNi-layered double hydroxide/graphene electronically controlled separation film. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1775-1783. doi: 10.11862/CJIC.20240043

Get Citation

PDF

XML

Metrics

PDF Downloads(6)
Abstract views(507)
HTML views(72)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142