Citation: SONG Xue-Jiao, LIU Zhuang. Applications of Nanotechnology for Physical Stimulus-Responsive Cancer Therapies[J]. Acta Physico-Chimica Sinica, ;2018, 34(2): 123-139. doi: 10.3866/PKU.WHXB201707042 shu

Applications of Nanotechnology for Physical Stimulus-Responsive Cancer Therapies

Institute of Functional Nano & Soft Materials(FUNSOM), Soochow University, Suzhou 215123, Jiangsu Province, P. R. China

Received Date: 25 May 2017
Revised Date: 21 June 2017

Fund Project: The project was supported by the National Natural Science Foundation of China (51525203) and Ministry of Science and Technology (MOST) of China (2016YFA0201200).

Multifunctional theranostic agents that are responsive to external physical stimuli such as light,magnetic field,ultrasound,radiofrequency,and X-rays have been widely explored for their use in physical stimulus-responsive therapies for cancer.Encouraging results in many preclinical animal experiments have been obtained;thus,this innovative strategy has gained great attention.Owing to the nontoxicity of physical stimulus-responsive agents and treatment specificity under particular external stimuli,physical stimulus-responsive cancer therapies provide greatly reduced toxicity and enhanced therapeutic efficiency compared with conventional chemotherapeutic agents.When combining physical stimulus-responsive therapies with other traditional therapeutics,synergistic antitumor effects via various mechanisms can be achieved.In this review,we will summarize the recent developments in physical stimulus-responsive therapies and discuss the important roles of nanoscale theranostic agents in these novel treatment modalities.
- Physical stimulus-responsive,
- Theranostic agent,
- Cancer therapy,
- Multifunctional,
- Combination therapy
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