Citation: LIU Teng, WANG Hai-Yang, XU Gui-Ying. Aggregation Behavior of PEO-PPO Block Polyethers and Their Application as a Drug Carrier[J]. Acta Physico-Chimica Sinica, ;2016, 32(5): 1072-1086. doi: 10.3866/PKU.WHXB201603071 shu

Aggregation Behavior of PEO-PPO Block Polyethers and Their Application as a Drug Carrier

1.
1 Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, P. R. China;
2.
2 Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, P. R. China

Corresponding author: LIU Teng,
Received Date: 23 December 2015
Available Online: 7 March 2016
Fund Project: 国家科技重大专项基金(2011ZX05024-004-08) (2011ZX05024-004-08)山东省优秀中青年科学家科研奖励基金(BS2014YY005)资助项目 (BS2014YY005)

Poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) block polyethers are typical nonionic polymeric surfactants, which allow for wide structural design, exhibit temperature-dependent micellization of the copolymers, and function in a variety of solvent systems. It greatly enriched the investigation of their aggregation behaviors in various solutions. In this paper, an overview based on our research work was provided about the basic properties of linear and branched PEO-PPO block polyethers in aqueous solutions. Furthermore, the effects of additives including acid/base, inorganic salts, alcohols, surfactants and polymers on the aggregation behaviors of PEO-PPO polyethers are examined. PEO-PPO block polyethers have good biocompatibility. They can form micelles in aqueous solutions, with a hydrophobic core and a hydrophilic corona around the micelle interior. This micelle structure provides local hydrophobic microenvironments for hydrophobic drugs. Thus, the application of PEO-PPO polyethers in the field of drug delivery is presented; they can be the theoretical dosage support structure in future drug discovery research.
- Pluronic,
- Tetronic,
- Branched block polyether,
- Aggregation behavior,
- Drug carrier
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