Citation: LI Ni-Na, GENG Li-Na, WANG Lin, YUAN Lin-Lin, CHANG Yan-Zhong, ZHANG Jian-Jun. Determination of Iron Liposome/Water Partition Coefficients and Identification of Influencing Factors[J]. Acta Physico-Chimica Sinica, ;2015, 31(11): 2043-2048. doi: 10.3866/PKU.WHXB201509141 shu

Determination of Iron Liposome/Water Partition Coefficients and Identification of Influencing Factors

1.
1 College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P. R. China;
2.
2 Testing and Analysis Center, Hebei Normal University Shijiazhuang 050024, P. R. China

Corresponding author: GENG Li-Na,
Received Date: 15 May 2015
Available Online: 9 September 2015
Fund Project: 国家自然科学基金(31201305) (31201305)河北省自然科学基金-石药集团医药联合研究基金(C2012205082)资助项目 (C2012205082)

Ferric citrate liposomes (FAC-Lip) and heme liposomes (Heme-Lip) were successfully prepared by a rotary-evaporated film-ultrasonication method. The release of iron liposomes were studied in vitro, and results showed that both iron liposomes had sustained-released properties, with Heme-Lip showing superior sustained-released over FAC-Lip. The liposome/water partition coefficients (P) were determined by equilibrium dialysis and the influences on P were evaluated, as well as the binding Gibbs free energy between FAC (Heme) and liposome. The results show that P initially increased and then decreased with increasing cholesterol content and the ratio of lipid to drug. The hydrogen and electrostatic interactions were largest when P was at its maximum. At the dialysis equilibrium, the binding Gibbs free energies (ΔG) of FAC-Lip and Heme-Lip were -12.7 and -18.2 kJ·mol^-1, respectively.
- Ferric citrate,
- Heme,
- Liposome/water partition coefficient,
- Equilibrium dialysis,
- Gibbs free energy
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