Citation: ZHAO Ji-Kuan, XIE Yan-Fang, XU Jie, HOU Wan-Guo. Preparation of Mg₂Al Layered Double Hydroxide Nanosheets from Triton X-100 Hexa nal Lyotropic Liquid Crystal and Their Application as Drug Carriers[J]. Acta Physico-Chimica Sinica, ;2015, 31(6): 1199-1206. doi: 10.3866/PKU.WHXB201504021 shu

Preparation of Mg₂Al Layered Double Hydroxide Nanosheets from Triton X-100 Hexa nal Lyotropic Liquid Crystal and Their Application as Drug Carriers

1.
1 State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, Shandong Province, P. R. China;
2 Key Laboratory of Colloid and Interface Chemistry Ministry of Education, Shandong University, Jinan 250100, P. R. China

Received Date: 19 January 2015
Available Online: 2 April 2015
Fund Project: 国家自然科学基金(20903059, 21173135, 21403121) (20903059, 21173135, 21403121)山东省自然科学基金(ZR2009BM043, ZR2013BQ013)资助项目 (ZR2009BM043, ZR2013BQ013)

A hexa nal lyotropic liquid crystal (LLC) was constructed with nonionic surfactant Triton X-100 and mixed magnesium chloride/aluminum chloride aqueous solutions. Layered double hydroxide (LDH) nanosheets (L-LDHs) were prepared using the LLC as a microreactor. A nanohybrid material of L-LDHs intercalated with a model anionic drug, diclofenac sodium (DS; DS/L-LDHs) was synthesized using an ionexchange method. The drug-release profile of DS/L-LDH was investigated under moderate conditions, i.e., 37.0 ℃ and pH 7.2. The results were compared with those for common LDH flaky particles (S-LDHs) synthesized using a traditional solution coprecipitation method. The crystalline structures, specific surface areas, and morphologies of these LDHs and DS/LDHs nanohybrids were characterized using powder X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and N₂ adsorption-desorption. The results show that the L-LDH JEparticles are less thick, and have larger specific surface areas and higher DS-loading capacities than the S-LDH particles. Drug release by the DS/L-LDH nanohybrid was clearly lower than that by the DS/S-LDH nanohybrid. This indicates that the L-LDH nanosheets are more suitable for use as drug carriers than the S-LDHs. Drug release by the DS/L-LDH nanohybrid can be described using a pesudo-second-order kinetic model, and drug diffusion through the LDH particles is the rate-limiting step. LLC can be used as a template for morphologycontrolled synthesis of LDHs.
- Layered double hydroxide,
- Lyotropic liquid crystal,
- Triton X-100,
- Nanohybrid,
- Drug release
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Preparation of Mg2Al Layered Double Hydroxide Nanosheets from Triton X-100 Hexa nal Lyotropic Liquid Crystal and Their Application as Drug Carriers

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通讯作者: 陈斌, bchen63@163.com

Preparation of Mg₂Al Layered Double Hydroxide Nanosheets from Triton X-100 Hexa nal Lyotropic Liquid Crystal and Their Application as Drug Carriers