Citation: YU Hui-Cheng, HUANG Xue-Yi, LI Hao, LEI Fu-Hou, TAN Xue-Cai, WEI Yi-Chun, WU Hai-Ying. Preparation and Electrochemical Properties of Phenobarbital Molecularly Imprinted Polymer Sensor Based on a CuO Nanoparticle-Modified Glassy Carbon Electrode[J]. Acta Physico-Chimica Sinica, ;2014, 30(11): 2085-2091. doi: 10.3866/PKU.WHXB201409051 shu

Preparation and Electrochemical Properties of Phenobarbital Molecularly Imprinted Polymer Sensor Based on a CuO Nanoparticle-Modified Glassy Carbon Electrode

1.
1. Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530006, P. R. China;
2. Guangzhou Research Institute of Nonferrous Metals, Guangzhou 510651, P. R. China

Received Date: 5 June 2014
Available Online: 5 September 2014
Fund Project: 广西教育厅科研项目(2013YB068) (2013YB068) 国家自然科学基金(21365004) (21365004) 广西自然科学重点基金(2013GXNSFDA019006) (2013GXNSFDA019006) 广西高等学校高水平创新团队及卓越学者资助计划(桂教人[2014]7 号) (桂教人[2014]7 号)广西研究生教育创新计划项目(gxun-chx2014120)资助 (gxun-chx2014120)

To improve the sensitivity of molecular imprinted electrochemical sensors, a molecularly imprinted polymer (MIP) film for the determination of phenobarbital (PB) was electropolymerized on a CuO nanoparticlemodified glassy carbon electrode. Methacrylic acid was used as the functional monomer and ethylene glycol maleic rosinate acrylate as a cross-linking agent in the presence of supporting electrolyte (tetrabutylammonium perchlorate). The electrochemical properties of CuO nanoparticle-modified molecularly imprinted and non-imprinted polymer (NIP) sensors were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). The results showed that the electrochemical properties of the CuO nanoparticle-modified MIP sensor were completely different from those of NIP sensors. X-ray diffraction confirmed that the nanoparticles were CuO. The morphology of the CuO nanoparticle-modified MIP sensor was examined under a scanning electron microscope. The CuO nanoparticles were uniformly distributed on the surface of the modified glassy carbon electrode, which improved the recognition sites of the modified MIP sensor. The response value of the DPV peak current showed linear dependence on the PB concentration in the range 1.0×10^-8 to 1.8×10^-4 mol·L^-1 (linear regression coefficient =0.9994) with a detection limit (S/N=3) of 2.3×10^-9 mol·L^-1. The results indicated that the CuO nanoparticle-modified MIP sensor is one of the most sensitive and selective sensors for PB determination. The prepared sensor was successfully applied for the determination of PB in practical samples and the recovery ranged from 95.0% to 102.5%.
- CuO nanoparticle,
- Phenobarbital,
- Molecular imprinted polymer,
- Electropolymerization,
- Sensor
1. [1]
  
  (1) Aiuba, C. A. F.; Gadermaier, G.; Oliveira, I.; Felzenszwalb, I.; Ferreira, F.; Pinto, L. F. R.; Eckle, P. Toxicol . Lett. 2011, 206, 139. doi: 10.1016/j.toxlet.2011.07.002
2. [2]
  (2) Vosough, M.; Ghafghazi, S.; Sabetkasaei, M. Talanta 2014, 119, 17. doi: 10.1016/j.talanta.2013.10.026
3. [3]
  (3) Paibir, S. G.; Soine,W. H. J. Chromatogr. B 1997, 691, 111. doi: 10.1016/S0378-4347(96)00437-9
4. [4]
  (4) Saka, K.; Uemura, K.; Shintani-Ishida, K.; Yoshida, K. J. Chromatogr. B 2008, 869, 9. doi: 10.1016/j.jchromb.2008.05.004
5. [5]
  (5) Heller, D. N. Anal. Chem. 2000, 72, 2711. doi: 10.1021/ac9913053
6. [6]
  (6) Raoof, J. B.; Baghayeri, M.; Ojani, R. Colloids Surf. B 2012, 95, 121. doi: 10.1016/j.colsurfb.2012.02.038
7. [7]
  (7) Zhao, N.; Hu, X. L.; Guan, P.; Song, R. Y.; Tian, T.; Zhang, X. R. Acta Phys. -Chim. Sin. 2014, 30 (1), 121. [赵娜, 胡小玲, 管萍, 宋任远, 田甜, 张向荣. 物理化学学报, 2014, 30 (1), 121.] doi: 10.3866/PKU.WHXB201311272
8. [8]
  (8) Fu, C.; Li, J. P. Chin. J. Anal. Chem. 2014, 42 (3), 315. [付丛, 李建平. 分析化学, 2014, 42 (3), 315.] doi: 10.3724/SP.J.1096.2013.30252
9. [9]
  (9) Wang, L.; Tan, X. C.; ng, Q.; Liu, L.; Zhao, D. D.; Lei, F. H.; Huang, Z. Y. Chin. J. Anal. Lab. 2012, 31 (6), 16. [王琳,谭学才, 龚琦, 刘力, 赵丹丹, 雷福厚, 黄在银. 分析试验室, 2012, 31 (6), 16.]
10. [10]
  (10) He, C. X.; Yuan, A. P.; Zhang, Q. L.; Ren, X. Z.; Li, C. H.; Liu, J. H. Acta Phys. -Chim. Sin. 2012, 28 (11), 2721. [何传新, 袁安朋, 张黔玲, 任祥忠, 李翠华, 刘剑洪. 物理化学学报, 2012, 28 (11), 2721.] doi: 10.3866/PKU.WHXB201207191
11. [11]
  (11) Zou, H.; Ni, X.; Pen, S. L.; Ouyang, J.; Chen, Y.; Ouyang, F. P. Acta Phys. -Chim. Sin. 2013, 29 (2), 250. [邹辉, 倪祥, 彭盛霖, 欧阳俊, 陈羽, 欧阳方平. 物理化学学报, 2013, 29 (2), 250.] doi: 10.3866/PKU.WHXB2012lll41
12. [12]
  (12) Shang, J.; Cao,W.;Wei, C. M.; Hu, J. B. Chin. J. Anal. Lab. 2010, 29 (1), 21. [尚军, 曹伟, 魏翠梅, 胡劲波. 分析试验室, 2010, 29 (1), 21.]
13. [13]
  (13) Liu, Y.; Guan, L. H.; Huang, X.; Song, Q. J. Chin. J. Anal. Chem. 2010, 38 (4), 569. [刘瑛, 管良慧, 黄新, 宋启军. 分析化学, 2010, 38 (4), 569.] doi: 10.3724/SP.J.1096.2010.00569
1. [1]
  Junjie Zhang , Yue Wang , Qiuhan Wu , Ruquan Shen , Han Liu , Xinhua Duan . Preparation and Selective Separation of Lightweight Magnetic Molecularly Imprinted Polymers for Trace Tetracycline Detection in Milk. University Chemistry, 2024, 39(5): 251-257. doi: 10.3866/PKU.DXHX202311084
2. [2]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
3. [3]
  Bao Jia , Yunzhe Ke , Shiyue Sun , Dongxue Yu , Ying Liu , Shuaishuai Ding . Innovative Experimental Teaching for the Preparation and Modification of Conductive Organic Polymer Thin Films in Undergraduate Courses. University Chemistry, 2024, 39(10): 271-282. doi: 10.12461/PKU.DXHX202404121
4. [4]
  You Wu , Chang Cheng , Kezhen Qi , Bei Cheng , Jianjun Zhang , Jiaguo Yu , Liuyang Zhang . ZnO/D-A共轭聚合物S型异质结高效光催化产H₂O₂及其电荷转移动力学研究. Acta Physico-Chimica Sinica, 2024, 40(11): 2406027-. doi: 10.3866/PKU.WHXB202406027
5. [5]
  Shicheng Yan . Experimental Teaching Design for the Integration of Scientific Research and Teaching: A Case Study on Organic Electrooxidation. University Chemistry, 2024, 39(11): 350-358. doi: 10.12461/PKU.DXHX202408036
6. [6]
  Jiajia Li , Xiangyu Zhang , Zhihan Yuan , Zhengyang Qian , Jian Zhu . 3D Printing Based on Photo-Induced Reversible Addition-Fragmentation Chain Transfer Polymerization. University Chemistry, 2024, 39(5): 11-19. doi: 10.3866/PKU.DXHX202309073
7. [7]
  Zijian Zhao , Yanxin Shi , Shicheng Li , Wenhong Ruan , Fang Zhu , Jijun Jiang . A New Exploration of the Preparation of Polyacrylic Acid by Free Radical Polymerization Based on the Concept of Green Chemistry. University Chemistry, 2024, 39(5): 315-324. doi: 10.3866/PKU.DXHX202311094
8. [8]
  Caixia Lin , Zhaojiang Shi , Yi Yu , Jianfeng Yan , Keyin Ye , Yaofeng Yuan . Ideological and Political Design for the Electrochemical Synthesis of Benzoxathiazine Dioxide Experiment. University Chemistry, 2024, 39(2): 61-66. doi: 10.3866/PKU.DXHX202309005
9. [9]
  Xiaomei Ning , Liang Zhan , Xiaosong Zhou , Jin Luo , Xunfu Zhou , Cuifen Luo . Preparation and Electro-Oxidation Performance of PtBi Supported on Carbon Cloth: A Recommended Comprehensive Chemical Experiment. University Chemistry, 2024, 39(11): 217-224. doi: 10.3866/PKU.DXHX202401085
10. [10]
  Endong YANG , Haoze TIAN , Ke ZHANG , Yongbing LOU . Efficient oxygen evolution reaction of CuCo₂O₄/NiFe-layered bimetallic hydroxide core-shell nanoflower sphere arrays. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 930-940. doi: 10.11862/CJIC.20230369
11. [11]
  Junli Liu . Practice and Exploration of Research-Oriented Classroom Teaching in the Integration of Science and Education: a Case Study on the Synthesis of Sub-Nanometer Metal Oxide Materials and Their Application in Battery Energy Storage. University Chemistry, 2024, 39(10): 249-254. doi: 10.12461/PKU.DXHX202404023
12. [12]
  Lei Shi . Nucleophilicity and Electrophilicity of Radicals. University Chemistry, 2024, 39(11): 131-135. doi: 10.3866/PKU.DXHX202402018
13. [13]
  Yingchun ZHANG , Yiwei SHI , Ruijie YANG , Xin WANG , Zhiguo SONG , Min WANG . Dual ligands manganese complexes based on benzene sulfonic acid and 2, 2′-bipyridine: Structure and catalytic properties and mechanism in Mannich reaction. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1501-1510. doi: 10.11862/CJIC.20240078
14. [14]
  Tao Cao , Fang Fang , Nianguang Li , Yinan Zhang , Qichen Zhan . Green Synthesis of p-Hydroxybenzonitrile Catalyzed by Spinach Extracts under Red-Light Irradiation: Research and Exploration of Innovative Experiments for Pharmacy Undergraduates. University Chemistry, 2024, 39(5): 63-69. doi: 10.3866/PKU.DXHX202309098
15. [15]
  Zijian Jiang , Yuang Liu , Yijian Zong , Yong Fan , Wanchun Zhu , Yupeng Guo . Preparation of Nano Zinc Oxide by Microemulsion Method and Study on Its Photocatalytic Activity. University Chemistry, 2024, 39(5): 266-273. doi: 10.3866/PKU.DXHX202311101
16. [16]
  Yuhao SUN , Qingzhe DONG , Lei ZHAO , Xiaodan JIANG , Hailing GUO , Xianglong MENG , Yongmei GUO . Synthesis and antibacterial properties of silver-loaded sod-based zeolite. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 761-770. doi: 10.11862/CJIC.20230169
17. [17]
  Chuanming GUO , Kaiyang ZHANG , Yun WU , Rui YAO , Qiang ZHAO , Jinping LI , Guang LIU . Performance of MnO₂-0.39IrO_x composite oxides for water oxidation reaction in acidic media. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1135-1142. doi: 10.11862/CJIC.20230459
18. [18]
  Xiaofeng Zhu , Bingbing Xiao , Jiaxin Su , Shuai Wang , Qingran Zhang , Jun Wang . Transition Metal Oxides/Chalcogenides for Electrochemical Oxygen Reduction into Hydrogen Peroxides. Acta Physico-Chimica Sinica, 2024, 40(12): 2407005-. doi: 10.3866/PKU.WHXB202407005
19. [19]
  Siyu HOU , Weiyao LI , Jiadong LIU , Fei WANG , Wensi LIU , Jing YANG , Ying ZHANG . Preparation and catalytic performance of magnetic nano iron oxide by oxidation co-precipitation method. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1577-1582. doi: 10.11862/CJIC.20230469
20. [20]
  Chunmei GUO , Weihan YIN , Jingyi SHI , Jianhang ZHAO , Ying CHEN , Quli FAN . Facile construction and peroxidase-like activity of single-atom platinum nanozyme. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1633-1639. doi: 10.11862/CJIC.20240162

Get Citation

PDF

XML

Metrics

PDF Downloads(569)
Abstract views(623)
HTML views(3)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142